Xinjiang Medical University

Latent multimorbidity patterns and their longitudinal associations with depressive symptom trajectories and ADL limitations among middle-aged and older adults in China: a longitudinal analysis of the CHARLS

Abstract Background Multimorbidity is heterogeneous, but longitudinal evidence from China on how specific disease patterns relate to changes in depressive symptoms and functional limitations remains limited. This study aimed to identify baseline multimorbidity patterns and examin...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Phage anti-defense genes targeting NAD + metabolism and DNA replication are associated with a broad host range against Klebsiella pneumoniae

. Deletion of these genes collapsed the host spectrum from 109 strains to fewer than 10, significantly compromising antibacterial efficacy. The wild-type phage substantially improves survival in a mouse bacteremia model. Our study identifies candidate genetic factors associated w...

Predictive model for mild cognitive impairment risk in community-dwelling older adults with depressive symptoms based on explainable machine learning: a cross-sectional study

Abstract Background: Mild cognitive impairment (MCI) represents a high-risk prodromal stage of Alzheimer’s disease, and its prevalence and conversion risk are higher among community-dwelling older adults presenting with depressive symptoms. Currently, there is a lack of interpret...

Experimental evaluation of Nilotinib and Paclitaxel co-delivered via albumin nanoparticles as a therapeutic strategy for lung squamous cell carcinoma

Chemotherapy remains the primary treatment for advanced lung squamous cell carcinoma (LUSC); however, its severe toxic side effects significantly limit therapeutic efficacy. There is an urgent clinical need to integrate molecular targeting with chemotherapy to enhance treatment o...

Stress hyperglycaemia ratio and post‐operative delirium after cardiac surgery: a retrospective cohort study of the MIMIC ‐ IV database

Abstract Background Post‐operative delirium is a serious neurocognitive complication of cardiac surgery. The stress hyperglycaemia ratio (SHR), which adjusts acute glucose levels to baseline glycaemia using glycated haemoglobin, has demonstrated superior prognostic value in criti...

Case report on new injection method for treating female Meige syndrome patients

Meige syndrome is an uncommon, long-lasting, and recurring form of craniofacial focal dystonia marked by bilateral blepharospasm and involuntary facial muscle contractions that greatly disrupt the daily activities and social interactions of those affected. The primary minimally i...

A bibliometric and visual analysis of PRMTs research publications for cancer (2006–2024)

Background: Protein arginine methyltransferases (PRMTs) have attracted considerable attention as potential targets for anticancer drug development. However, no bibliometric analysis of research articles on PRMTs in the field of oncology has been reported to date. To establish a k...

Demographic time bomb in COPD (1990–2050)

Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality, characterized by irreversible airflow limitation and progressive symptoms. Despite declining age-standardized rates (ASRs), absolute burdens are rising due to population aging and g...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Incidence, Management, and Clinical Outcomes of Cardiovascular Adverse Events in Patients Receiving ALK Inhibitors for Advanced Non-Small Cell Lung Cancer: A Real-World Single-Center Analysis

Cardiovascular adverse event (CVAE) profiles across ALK-TKI generations remain incompletely characterized in real-world practice. A retrospective study of 235 ALK-rearranged NSCLC patients receiving first-, second-, or third-generation ALK-TKIs assessed CVAE incidence, severity,...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

Qufeng Zhijing Capsule attenuates airway inflammation in experimental asthma and is associated with c-Myc/YTHDF1/TRPV1-related signaling

Background Qufeng Zhijing Capsule (QFZJ) is a traditional Chinese medicine formulation used for asthma-related respiratory symptoms, but its effects on airway epithelial inflammation and the underlying molecular mechanisms remain unclear. Methods OVA-induced asthmatic rats receiv...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

FABP4 and L-acetylcarnitine as candidate biomarkers for small airway dysfunction in children with obese type 2 asthma: a pilot cross-sectional multi-omics study

Childhood obesity-associated asthma represents a distinct phenotype with incompletely understood metabolic mechanisms. This hypothesis-generating study aimed to screen candidate biomarkers associated with small airway dysfunction in children with obese type 2 asthma and explore p...

Latent profiles of health empowerment and associated factors among older adults hospitalised with stroke: a single-centre cross-sectional study

This study aims to explore the health empowerment of elderly ischemic stroke patients in China and analyze its associated factors. Ischemic stroke patients hospitalized in the Department of Neurology and Rehabilitation of a tertiary hospital in Daqing from June 2025 to March 2026...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...