Xinjiang Medical University

Triaxial Accelerometry Sensor for Respiratory-Effort Phase Landmark Detection During Sleep: A Cross-Modal Weak Supervision Approach

Reliable respiratory phase sensing is important for respiratory-synchronized hypoglossal nerve stimulation (HGNS), but conventional sensing approaches may impose additional burden. This pilot study investigated whether a surface triaxial accelerometry sensor (TAS) could detect th...

Health inequalities in the global reproductive-age population: GBD 2021 trends and female-male differences, 1990–2021

Socioeconomic health inequality among reproductive-age populations remains insufficiently characterized globally. Using GBD 2021 data for individuals aged 15–49 years in 204 countries and territories, we assessed disability-adjusted life year (DALY) rates and quantified absolute...

Sequential Meridian Based Acupuncture Combined With Standard Rehabilitation After Surgery for Severe Cubital Tunnel Syndrome

Objective: To evaluate the efficacy of sequential meridian-based acupuncture combined with standard rehabilitation in patients after surgery for severe cubital tunnel syndrome (CuTS). Methods: In this prospective randomized controlled trial, 40 patients with severe CuTS who under...

Diagnostic value of plasma TFF3‐centered combined biomarker panel in early gastrointestinal cancer

ABSTRACT Gastrointestinal (GI) tumors represent a significant global health burden, necessitating robust strategies for early detection. However, the clinical utility of conventional protein biomarkers such as carcinoembryonic antigen (CEA), carbohydrate antigen 19‐9 (CA19‐9) in...

Biomechanical comparison of two-, three-, and four-screw zero-profile ACDF constructs: effects of screw number and orientation

Zero-profile anterior cervical discectomy and fusion (ACDF) constructs vary in screw number and trajectory, but their effects on immediate stability and load transfer remain unclear. This study compared two-, three-, and four-screw constructs and examined middle-screw orientation...

The early-onset pancreatic cancer paradox: a systematic review and meta-analysis

BACKGROUND: Globally, the rate of early-onset pancreatic cancer (EOPC) is increasing, but its clinical features and outcomes relative to average-onset pancreatic cancer (AOPC) remain uncertain. We compared clinicopathological features, treatment patterns, and survival outcomes. M...

Fluorination‐Driven Molecular Polarization Engineering in Hydroxyfluorooxoborates for Generating Strong Short‐Wavelength Nonlinear Optical Responses

ABSTRACT The short‐wavelength ultraviolet (UV, <280 nm) all‐solid‐state lasers, which rely on nonlinear optical (NLO) crystals for second‐harmonic generation (SHG), are of great significance for advanced scientific and industrial. However, the inherent randomness of obtaining non...

RCTE: A multi-class object detection framework for dental panoramic radiographs

Background Dental panoramic radiographs play an important role in oral disease screening, computer-aided diagnosis, and clinical treatment planning. However, accurate multi-class detection remains challenging due to small lesion sizes, ambiguous anatomical boundaries, insufficien...

Serum basic amino acids, prolactin, and insomnia severity in perimenopausal individuals: a cross-sectional sub-study

Insomnia symptoms are common during the menopausal transition, but estrogen-centered explanations do not fully account for inter-individual variation. We examined whether serum prolactin was associated with insomnia severity and whether circulating basic amino acids modified this...

Detection and genomic characterization of tet(X4)-positive Escherichia coli in retail pig products in Xuancheng, China

Tigecycline is considered a last-resort antibiotic against multidrug-resistant Gram-negative bacteria. The emergence of the mobile resistance gene tet (X4), which confers high-level resistance to tigecycline, has raised growing concern due to its rapid dissemination among humans,...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

A genealogical critique of medicalization: from Conrad back to Foucault

Abstract: Foucault’s genealogy is widely applied in discussions of medicalization. Critics such as Conrad have adopted Foucault’s power-knowledge analysis as a crucial tool for critiquing it. However, these critiques often tend to view medicalization excessively as a negative phe...

Comparison of efficacy and safety between unilateral biportal endoscopy and percutaneous endoscopic surgery for cervical spondylotic radiculopathy based on current evidence: a systematic review and meta-analysis

A systematic comparison of the clinical efficacy and safety between Unilateral Biportal Endoscopy (UBE) and Percutaneous Endoscopy (PE) in the Treatment of Cervical Spondylotic Radiculopathy (CSR). Computerized searches were conducted in PubMed, Cochrane Library, Web of Science,...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...

Association between controlling nutritional status score and left ventricular hypertrophy in adults

Left ventricular hypertrophy (LVH) is an important marker of cardiovascular risk, while malnutrition is common among adults. The Controlling Nutritional Status (CONUT) score is an objective tool for nutritional assessment. This study aimed to investigate the associations of CONUT...

Perioperative prediction of ideal postoperative recovery after kidney transplantation: a multicenter retrospective cohort study

Kidney transplantation is the preferred treatment for end-stage renal disease, but early postoperative outcomes remain heterogeneous. Textbook outcome (TO), a composite measure of an ideal postoperative recovery trajectory, has emerged as a meaningful indicator of surgical qualit...

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Integrating single-cell RNA sequencing with Visium HD spatial atlas reveals immune–stromal cell interactions in Echinococcus multilocularis metacestode infection

Abstract Background Alveolar echinococcosis (AE), caused by the larval stage of the tapeworm Echinococcus multilocularis , is a fatal zoonotic disease characterized by progressive hepatic granulomatous inflammation and fibrosis. However, the mechanisms underlying the pathological...