Xinjiang Medical University

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

WEM-Mamba: a Wavelet-Enhanced MedMamba framework for rotator cuff tear classification in X-ray images

Rotator cuff tear is a common cause of shoulder pain and functional impairment, and its accurate identification is of great significance for clinical treatment decisions. Magnetic Resonance Imaging (MRI) is generally regarded as the important imaging modality for evaluating soft...

Multidimensional analysis on the potential of cell cycle-related gene STMN1 as a tumor biomarker

STMN1 is a critical microtubule-destabilizing protein that controls cell division and cytoskeleton dynamics and participates in tumor initiation and progression. Nevertheless, systematic pan-cancer research on its function, clinical significance and therapeutic value is still lac...

Vericiguat for Post-Myocardial Infarction Heart Failure Prevention: From Molecular Mechanisms to Clinical Translation

Abstract Myocardial infarction (MI) remains a major cause of morbidity and mortality, largely due to the development of heart failure (HF). More molecular mechanisms should be investigated concerning the pathophysiology of HF after MI since current therapies for reperfusion and c...

Association of hyperchloremia with mortality and acute kidney injury in critically ill children: a systematic review and meta-analysis

Abstract Background Blood chloride disturbances are common in critically ill children. However, the prognostic significance of hyperchloremia remains uncertain because serum chloride abnormalities may be confounded by the severity of the underlying illness. This systematic review...

Antitumor effects of magnesium-based materials through the ferroptosis pathway

Magnesium-based materials offer unique advantages in clinical applications owing to their biodegradability and osteogenic activity; however, the excessively rapid degradation of pure magnesium limits its clinical translation. This review systematically integrates the latest advan...

Early transmission risks of Ebola disease outbreak caused by Bundibugyo virus in the Democratic Republic of the Congo

An outbreak of Ebola disease caused by Bundibugyo virus (BDBV) has been ongoing since April 2026, primarily in the Democratic Republic of the Congo. We estimated the initial reproduction number of BDBV at 1.85 (95% CrI: 1.09, 3.25), underscoring the urgent need for timely impleme...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Cholesterol sulfate as a novel theranostic target for sepsis-induced liver injury through Beclin1-mediated autophagy enhancement and pyroptosis suppression

Sepsis remains a life-threatening syndrome, and septic liver injury is a frequent and critical complication for which no specific pharmacological therapy exists. Current biomarkers lack sufficient specificity for early diagnosis and severity assessment, highlighting an urgent nee...

Association between subjective well-being and the risk of cardiometabolic multimorbidity in older Chinese adults: effect modification by the integrated healthy lifestyle score

This study aimed to ascertain the association between subjective well-being (SWB) scores and the cardiometabolic multimorbidity (CMM) risk, and evaluate the potential modifying effect of integrated healthy lifestyle scores among older Chinese adults. A prospective cohort study wa...

Identification and mechanistic study of metabolic-immune subtypes in COPD based on integrated transcriptomic-metabolomic analysis

This study aimed to characterize immune cell metabolic alterations and their regulatory mechanisms in chronic obstructive pulmonary disease (COPD), and to identify metabolism-related immune subtypes associated with lung dysfunction to support immunometabolic classification and ta...

Stage-dependent activation of the circulating AIM2–caspase-1–GSDMD axis in silicosis: a cross-sectional study

Silicosis is a progressive occupational lung disease caused by long-term inhalation of crystalline silica, in which persistent inflammation contributes to lung injury and fibrotic remodeling. Experimental studies suggest that DNA-sensing pathways involving AIM2 may be engaged aft...

Single-Cell Transcriptomic Profiling of the O -Methyltransferase Characteristics of Flavonoid Biosynthesis in Ziziphus jujuba var. spinosa Fruit

Abstract Sour jujube (Ziziphus jujuba var. spinosa) is a valuable medicinal and edible fruit owing to its health-promoting properties. Methoxylated flavonoids enhance their value by improving stability and bioavailability. However, the cellular basis of their biosynthesis remains...

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

ABSTRACT Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DK...

Evaluation of the antibacterial activity of turkish gall extract against Staphylococcus aureus ATCC 6538

Abstract Background Staphylococcus aureus is a common foodborne pathogen and a frequent cause of clinical infections. It forms dense biofilms by adhering to surfaces of objects or the human body, thereby reducing the bactericidal efficacy of antibiotics and disinfectants. This st...

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

ABSTRACT The treatment of diabetic wounds remains a major challenge due to persistent bacterial infections, chronic inflammation, and impaired angiogenesis. To address these issues, we develop an immunomodulatory and antibacterial hydrogel integrating epidermal growth factor (EGF...

Early SOX9 Activation Primes Hippo– YAP / TAZ Rewiring During Glioblastoma Stemness Acquisition

Glioblastoma progression is driven by stemness acquisition and cellular plasticity, yet the temporal and spatial organization of these processes remains incompletely defined. In this study, single-cell RNA sequencing, pseudotime reconstruction, spatial transcriptomics, and in vit...

Associations of remnant cholesterol and apolipoprotein B with kidney function decline and progression to kidney failure in hospitalized patients with type 2 diabetic kidney disease: a retrospective cohort study

Diabetic kidney disease (DKD) is one of the leading causes of kidney failure (KF). Emerging lipid markers such as remnant cholesterol (RC) and apolipoprotein B (ApoB) have been associated with kidney disease progression. However, no study has comprehensively evaluated the associa...

Establishment Reference Intervals Using the Kosmic Algorithm for Hemoglobin Levels and Platelet, Red Blood Cell, and White Blood Cell Counts

INTRODUCTION: Reference intervals (RIs) for complete blood count (CBC) are crucial for assessment of overall health status and effective diagnosis of diseases. However, the RI data for CBC currently used in clinical practice in China are mainly derived from the Han Chinese popula...

Evaluating global clinical trials and development trends of antibody-drug conjugates

Antibody-drug conjugates (ADCs) represent a breakthrough in tumor-targeted therapy, showing promise in both solid tumors and hematological malignancies. By 1 September 2025, more than 370 ADC candidates had entered clinical development, 17 unique products had received at least on...