Xiangya Hospital Central South University

Associations between non-insulin-based insulin resistance surrogates and pulmonary hypertension due to left heart failure: a multicenter cohort study

Abstract Background Insulin resistance (IR) has been reported to have a close relationship with the development and adverse outcomes of various cardiovascular disorders, while its association with pulmonary hypertension due to left heart failure (PH-HF) remains to be elucidated....

Dendrobine Attenuates Cisplatin-Induced Acute Kidney Injury with KEAP1–NRF2 Activation and Reduced Ferroptosis-Associated Stress

Acute kidney injury (AKI) lacks effective pharmacological therapies, and ferroptosis-associated lipid peroxidation contributes to renal tubular injury. Here, we investigated the protective effects of dendrobine against AKI and its mechanisms. Dendrobine was evaluated in murine ci...

Between-cohort variation in the cardiovascular association and predictive utility of the triglyceride-glucose waist circumference index among ageing adults in China, England, and the United States

Low-cost metabolic indices could support cardiovascular screening, but their utility may vary across populations. We evaluated between-cohort variation in the association, incremental predictive value, and absolute-risk performance of the triglyceride-glucose waist circumference...

Shared genetic architecture between constipation and aging-related phenotypes

While the frequency of constipation increases sharply with age, the genetic links between constipation and aging-related phenotypes remain largely unexplored. So far, research has typically focused only on individual characteristics while neglecting broader genetic connections. I...

Comprehensive landscape and future perspectives of PIWI‑interacting RNAs in cancer (Review)

P‑element induced wimpy testis (PIWI)‑interacting RNAs (piRNAs) are small non‑coding RNAs with a length of ~24‑32 nucleotides that specifically bind members of the PIWI protein family. Initially identified in germ cells, piRNAs have since been detected in various somatic cells. T...

Ultra‐Sensitive, Decoupled Multimodal Sensing via Dual‐Network Iontronic Organohydrogels

ABSTRACT Flexible sensors capable of mimicking human skin's multimodal perception are highly desired for wearable electronics. However, achieving inherently decoupled detection of multiple physical stimuli in a single device remains a fundamental challenge. Here, a polyacrylamide...

Disease‐Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta‐analysis

ABSTRACT Background Optimal glucose targets for critically ill patients are likely to vary by underlying condition, yet a ‘one‐size‐fits‐all’ approach persists. Aim Determining disease‐specific glucose thresholds may help achieve the lowest mortality rates. Study Design This stud...

Comparative Efficacy of Electrical Stimulation Therapies for Bone Healing

Objective: This network meta-analysis aimed to evaluate the effectiveness of electrical stimulation (ES) in promoting bone healing and to identify the optimal modality. Design: This network meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analy...

The Oxidized Phospholipid PGPC Impairs Angiogenesis by Inhibiting Endothelial Autophagosomal–Lysosomal Fusion Through NPC1-Induced Syntaxin 17 Acetylation and Ubiquitination

BACKGROUND: Angiogenesis is essential for the recovery of ischemic hearts with coronary artery disease (CAD). PGPC (1-palmitoyl-2-glutamyl-sn-glycero-3-phosphocholine) is a major phospholipid oxidation product in atherosclerotic lesions. Autophagy participates in angiogenesis. Ho...

Young bone marrow mesenchymal stem cell-derived exosomes promote perfusion recovery and tissue repair via the miR-455-5p/Bach1 axis after hindlimb ischemia

Lower-limb ischemia caused by peripheral arterial disease (PAD) results in sustained perfusion impairment and tissue injury, and effective regenerative therapies remain limited. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) are a promising cell-free therapeutic s...

Lactate suppresses T follicular helper cells in lupus in association with metabolic-epigenetic reprogramming

Aberrant CD4⁺ T cell differentiation, particularly the expansion of T follicular helper (Tfh) cells, is a hallmark of systemic lupus erythematosus (SLE) and is critically dependent on metabolic reprogramming. Although altered lactate metabolism has been implicated in autoimmune d...

Multi-cell death gene signature predicts lung adenocarcinoma prognosis and reveals FURIN regulates ferroptosis via NRF2-xCT-GPX4 axis

FURIN, a proprotein convertase, has been implicated in tumor progression. Nevertheless, how it contributes to lung adenocarcinoma (LUAD) and ferroptosis is still not well understood. We investigated FURIN expression and its prognostic value using the TCGA-LUAD cohort, CPTAC, and...

The Executioners of Mitochondrial Apoptosis: Structures, Mechanisms, and Therapeutic Advances of BAX, BAK, and BOK

ABSTRACT The BCL‐2 family effector proteins BAX, BAK, and BOK are pivotal regulators of the mitochondrial apoptosis pathway. They act as the ultimate executioners responsible for the irreversible step of mitochondrial outer membrane permeabilization. Their molecular conformations...

Complex metatarsal defect reconstruction with vascularized bone and soft-tissue flaps

Complex metatarsal defects, particularly those accompanied by soft-tissue loss, are difficult to reconstruct because both skeletal continuity and durable wound coverage must be restored. Existing evidence is largely limited to isolated case reports and small series with short fol...

Application of Retrieval-Augmented Generation Large Language Models in Stomatology: A Scoping Review

Large language models (LLMs) have been gradually applied to tasks such as specialized question answering, educational assistance, clinical decision support, and knowledge integration in stomatology. However, general-purpose LLMs still suffer from critical limitations, including o...

Complications and revisions of inlay versus onlay design for reverse shoulder arthroplasty: a meta analysis and systematic review

Reverse total shoulder arthroplasty (RTSA) is the standard treatment for rotator cuff tear arthropathy; humeral stems are classified as inlay or onlay, but their comparative risks of complications and revision remain unclear. This systematic review evaluates these outcomes to inf...

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

BACKGROUND: Gliomas are metabolically heterogeneous tumors in which mitochondria coordinate bioenergetics, biosynthesis, redox homeostasis, stress adaptation, and treatment responses. This review examines mitochondrial dependencies across glioma subtypes and cell states. METHODS:...

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

ABSTRACT Aberrant macrophage polarization is one of the key mechanisms underlying chronic obstructive pulmonary disease (COPD), but the underlying processes have not yet been fully elucidated. Lactylation is a novel lactate‐derived post‐translational modification and is relativel...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Succinate Ameliorates Sepsis‐Associated Acute Kidney Injury by Mediating Inflammation via GPR91

Succinate is a key metabolic intermediate in the tricarboxylic acid (TCA) cycle, which participates in energy metabolism. It accumulates under various pathological conditions and exerts regulatory effects through binding to its specific receptor GPR91. However, its specific funct...