Xiangya Hospital Central South University

Succinate Ameliorates Sepsis‐Associated Acute Kidney Injury by Mediating Inflammation via GPR91

Succinate is a key metabolic intermediate in the tricarboxylic acid (TCA) cycle, which participates in energy metabolism. It accumulates under various pathological conditions and exerts regulatory effects through binding to its specific receptor GPR91. However, its specific funct...

Estrogen receptor alpha variants differentially influence proliferation and inflammatory responses in in vitro models of lupus inflammation

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease with female predominance that involves multiple factors, including sex chromosomes, sex hormones, and sex hormone receptor isoforms/variants, such as estrogen receptor alpha (ERα). The mechanisms of n...

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

Cancer heterogeneity drives therapeutic failure, resistance, and relapse and encompasses variation across genetic, cellular, tissue, organ, and systemic scales. Existing frameworks define malignant capabilities and tumor–microenvironment interactions but less explicitly address h...

Fibroblast-associated migrasome programs define TSPAN4-driven progression and clinical risk stratification in gastric cancer

Gastric cancer (GC) is a highly aggressive malignancy with poor prognosis, characterized by complex tumor microenvironment (TME) interactions. Migrasomes have been implicated in cancer progression, but their specific roles and spatial correlation in GC remain unclear. Using 10x G...

Integrated multi-omics decodes the AKI-to-CKD transition: from ensemble discovery to structure-guided translational targeting

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) constitutes a major global health burden. Identifying causal drivers remains challenging due to proteomic complexity and confounding biases. We aimed to construct a discovery framework to identify actio...

Comparison of demographic, clinical, and psychological characteristics among patients with irritable bowel syndrome meeting the Rome clinical, Rome V, and Rome IV criteria

BACKGROUND: The Rome clinical criteria for irritable bowel syndrome (IBS) were introduced to improve clinical applicability and represent an important advancement within the Rome V process. However, their clinical profiles relative to the standard Rome criteria remain unclear. ME...

Glycosides from Cistanche tubulosa suppress intestinal ACSL4-mediated ferroptosis to ameliorate depression with intestinal dysfunction symptoms through regulating arachidonic acid metabolism

Abstract Background Depression is highly comorbid with intestinal dysfunction, yet antidepressant therapies are limited by suboptimal efficacy and frequent gastrointestinal adverse effects. Existing cellular and animal data support the potentially dual protective effects of total...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Clinical features and prognostic factors in paediatric medulloblastoma: a retrospective cohort study

To evaluate the clinical characteristics, outcomes, and prognostic factors associated with paediatric medulloblastoma (MB). We retrospectively analysed paediatric MB patients treated at Xiangya Hospital Central South University from January 2015 to July 2023. Overall survival (OS...

Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications

Microneedling has found various applications in dermatology recently. However, many problems still need to be solved in the fabrication of high-aspect-ratio polymeric microneedles with good mechanical strength, dimensional accuracy and thermal conductivity for energy-assisted tre...

Automatic segmentation of malignant pulmonary nodules on LUNA16 subsets using an attention-guided 3D U-Net framework

Objective Lung cancer is the leading cause of cancer-related mortality worldwide, and accurate segmentation of malignant pulmonary nodules is essential for quantitative lesion analysis and computer-aided lung cancer screening. Manual segmentation is time-consuming and highly depe...

Facilitators and barriers influencing the implementation of type 2 diabetes remission programmes: a qualitative meta-synthesis from a multi-stakeholder perspective

Although type 2 diabetes (T2D) remission has emerged as a promising therapeutic goal, its implementation in real-world settings faces considerable challenges. Understanding the perspectives of multiple stakeholders is essential to address these implementation challenges. This met...

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

To elucidate the molecular structure, oligomerization mechanisms, and roles of Ninjurin-1 (NINJ1) in regulated cell death (RCD) pathways (pyroptosis, necroptosis, ferroptosis, secondary necrosis, PANoptosis) and its dual role in cancer (tumor suppressor vs. pro-tumor factor). Sys...

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study

Indiscriminate antibiotic use remains common in febrile patients with acute necrotizing pancreatitis (ANP), particularly during the early phase. Metagenomic next‑generation sequencing (mNGS) has shown diagnostic utility for infected pancreatic necrosis (IPN) and may offer a means...

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...

SIRT3-dependent mitochondrial redox homeostasis protects against age-related tendon degeneration

Aims: Mitochondrial redox homeostasis is closely linked to the ageing processes of tendons, whether in normal or pathological conditions. This study employed an innovative approach to examine the role of sirtuin 3 (SIRT3) in mitochondrial dysfunction in the aged murine supraspina...

Prognostic Associations of BMI and Metabolic Syndrome With Outcomes After Anti‐ PD ‐1 Therapy in Recurrent or Metastatic Nasopharyngeal Carcinoma

ABSTRACT To evaluate the associations of body mass index (BMI) and metabolic syndrome (MetS) with outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M‐NPC) receiving anti‐PD‐1 therapy, and to develop a prognostic model for overall survival (OS). This mu...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

Age- and Phenotype-Specific Patterns of Atopic and Autoimmune Comorbidities in Alopecia Areata: A Cross-Sectional Study

Background: Alopecia areata (AA) is frequently associated with atopic and autoimmune comorbidities, yet comprehensive data in Chinese populations remain scarce. We aimed to characterize the comorbidity landscape and identify predictors of the total comorbidity count in AA patient...

Comparative proteomics of human anterior lens capsules reveals ATP6V1A-associated lysosomal dysregulation in age-related cataract with primary angle-closure glaucoma

Lens-related mechanisms in primary angle-closure glaucoma (PACG) remain incompletely defined. The anterior lens capsule (ALC) is a biologically active interface, but its molecular landscape in PACG is largely unknown. We aimed to define proteomic alterations in human ALCs from ag...