Xiangya Hospital Central South University

Exposure to Size-Fractioned Ambient Particles Associated with Alterations in Gut Microbiome and Pro-Atherosclerotic Biomarkers in Young Adults

Abstract Background: Ambient fine and ultrafine particles are linked to the progression of atherosclerotic cardiovascular diseases, wherein gut microbiome may play a critical role. However, the underlying mechanisms and relevant metabolic pathways are not yet fully understood. Ob...

Association between post-exercise heart rate recovery and one-year clinical deterioration in COPD: a retrospective longitudinal analysis

The application of cardiopulmonary exercise testing (CPET) for assessing heart rate recovery at 1 min (HRR1) is of significant clinical value in evaluating disease severity, cardiovascular risk, and prognosis in patients with cardiovascular diseases. However, its utility in patie...

Multi omics landscape of AGTRAP in ammonia induced cell death and cervical cancer progression

Abstract Background Cervical cancer (CESC) remains a leading cause of cancer-related mortality among women worldwide. Ammonia‑induced cell death, a recently identified metabolic cell death process, plays a significant yet incompletely understood role in tumor progression. Its reg...

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes

Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high intraocular pressure (ph-IOP). Despite the established role of ferroptosis in RGC degeneration, specific molecular...

Vesicular trafficking in immune regulation and disease: from intracellular sorting to intercellular communication

Vesicular trafficking is a fundamental mechanism that maintains cellular homeostasis, enables precise material transport, and regulates signal transduction in eukaryotic cells. In immune cells, vesicular trafficking supports dynamic membrane remodeling and activation-dependent ve...

The Effect of Pore Size on Cell Ingrowth in PLLA/HA Scaffolds for Bone Tissue Engineering.

In bone regenerative medicine, scaffolds play a pivotal role in promoting cell adhesion, proliferation, and differentiation. Among the various materials employed for creating scaffolds, mixed materials composed of poly-l-lactic acid and hydroxyapatite (PLLA/HA) have emerged as a...

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

ABSTRACT Metabolic remodeling is one of the hallmarks of malignant tumors, and post‐translational modifications of proteins, such as succinylation, play an important role in the process of metabolic remodeling by regulating the function of metabolic enzymes. However, the role of...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Glutathione S‐Transferase Omega 1 Promotes Macrophage Inflammation‐Associated Coagulopathy in Sepsis by S‐Glutathionylating ANXA5 to Enhance Its Ubiquitination

ABSTRACT Sepsis‐associated coagulopathy contributes to organ dysfunction and mortality. Macrophage‐mediated inflammation disrupts anticoagulant homeostasis, but the role of glutathione S‐transferase omega 1 (GSTO1) in this process remains unclear. Clinical samples from sepsis pat...

Plasma proteome reflects tissue damage and clinical manifestations in patients with inflammatory myopathies

OBJECTIVE: Tissue-specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating cle...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone

ABSTRACT Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and improve adherenc...

Endothelial Cell-Pericyte Interplay in Ischemic Stroke: Unraveling Pathogenic Networks and Translational Frontiers

Ischemic stroke remains a leading cause of death and long-term disability worldwide. Increasing evidence indicates that endothelial cell-pericyte (EC-PC) crosstalk is not merely a structural feature of the neurovascular unit, but a dynamic regulatory axis that shapes blood-brain...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.

Oncogenic USP3 promotes hepatocellular carcinoma progression via K11/K48-specific deubiquitination and stabilization of YAP

Hepatocellular carcinoma (HCC) has a poor prognosis, necessitating therapeutic targets, while the role of ubiquitin-specific protease 3 (USP3) in HCC remains unclear. This study aimed to elucidate the function of the deubiquitinating enzyme USP3 in HCC. USP3 was found to be highl...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Neutropenia events with androgen receptor pathway inhibitor-containing versus control therapies in prostate cancer patients: a systematic review and meta-analysis

To systematically evaluate the risk of neutropenia associated with androgen receptor pathway inhibitor (ARPI) intensification in patients with prostate cancer across phase 3 randomized controlled trials. This systematic review and meta-analysis was conducted in accordance with PR...

Clcn6 mRNA and ClC-6 protein expression in mouse central nervous system

To investigate the expression patterns of Clcn6 mRNA and ClC-6 protein in postnatal mouse of distinct region of central nervous system (CNS) and developmental stages. Distinct CNS regions, including cerebral cortex, hippocampus, cerebellum, brainstem, olfactory bulb, hypothalamus...

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...