Westlake University

Gate-imprinted memory and light-induced erasure of superconductivity at KTaO3-based interfaces

Realizing non-volatile control of superconductivity is a key step toward integrating memory and quantum functionality in future information technologies. KTaO₃-based heterostructures uniquely host interfacial two-dimensional superconductivity and quantum paraelectric lattice back...

Enantioselective Convergent Synthesis of Heterohelicenes via Copper-Catalyzed Propargylic Annulation/Acid-Promoted Aromatization

Abstract Heterohelicenes combine helical chirality with tunable electronic properties, making them attractive for applications in chiral materials and optoelectronics. However, their enantioselective synthesis, particularly for five-membered heterohelicenes, remains a long-standi...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

Multidisciplinary diagnosis and treatment of lingual thyroid presenting as hematemesis

Rationale: Hematemesis is a common symptom of gastrointestinal disorders and is often associated with upper gastrointestinal issues. However, lingual thyroid, a rare ectopic thyroid condition, can also present with hematemesis, complicating diagnosis and increasing the risk of mi...

Structural basis of fatty acid activation and transport by human FATP2

Fatty acid transport proteins (FATPs) are responsible for efficient uptake of fatty acids (FAs), essential biomolecules that play critical roles in development and growth. However, the lack of three-dimensional structures of FATPs has hindered our understanding of their mechanism...

Influence of Isokinetic Muscle Strength Training Combined With Early Functional Exercise on Joint Function After Knee Cruciate Ligament Reconstruction

AIM: The purpose of this study was to evaluate and analyze the influence of isokinetic muscle strength training combined with early functional exercise on joint function after knee cruciate ligament reconstruction.METHODS: A total of 294 patients undergoing knee cruciate ligament...

Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells

γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T-cell receptor (TCR), which is expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. However, the molecular mechanism...

Consistency of urethroscopy vs. high-frequency ultrasound in diagnosing male urethral condyloma acuminatum

Abstract Objectives Urethral condyloma acuminatum(CA) is characterized by hidden growth, high treatment difficulty, high recurrence rate, and significant harm. Urethroscopy is a traditional method for examining male urethral CA. As a safe, non-invasive, highly reproducible, and c...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Computational Discovery of Novel Sulfide Lithium Superionic Conductors via a Structural‐Feature‐Constrained Generative Model

ABSTRACT Recent advances in generative models have opened new avenues for discovering novel materials with desired properties by steering generation toward property constraints. However, for properties that are scarce, inconsistent across different sources, or difficult to obtain...

Molecular characteristics and formation pathways of organosulfur compounds: a comparative field study across contrasting atmospheric environments

Abstract. Organosulfur compounds (OrgSs), especially organosulfates (OSs), are ubiquitous aerosol components. However, the spatial, seasonal, and day-night variations of OrgS formation in polluted atmospheres remain poorly understood. Here, we monitored particulate OrgSs at an ur...

Mitigating Stress‐Induced Nonphotoactive Phase Transition Through Sodium Sulfonate Engineering for Stable and Efficient Perovskite Solar Cells

ABSTRACT Formamidinium lead triiodide (FAPbI 3 ) perovskite solar cells (PSCs) have attracted significant attention due to their outstanding optoelectronic properties. However, their long‐term stability remains limited by lattice strain‐induced transition from the photoactive α‐p...

Multi-ancestry conditional and joint analysis applied to GWAS summary statistics

Manc-COJO (Multi-Ancestry Conditional and Joint Analysis) is a C++ software package for identifying independent association signals from multi-ancestry GWAS summary statistics. By jointly modelling association signals across ancestry groups while accounting for ancestry-specific...

Chromium‐Catalyzed Stereodivergent Carbonyl Addition Dictated by Non‐Covalent Interactions

ABSTRACT Catalytic stereodivergent synthesis, which accesses the full complement of stereoisomers from a common precursor set, is a paramount objective in drug discovery. However, achieving this control via radical‐involved pathways remains a formidable frontier due to the transi...

Potential structure induced effects of the hairpin motif in RNA to form the phase separated droplet like associate in different solution condition

Reversible associations of RNAs among themselves, or with RNA binding proteins through the process of phase separation, are found to be important in many different cellular contexts, including cellular responses to stress, gene regulation, development, and disease. Short RNA repe...

Sustainable ammonia synthesis from nitrate wastewater via graphdiyne Mo–Cu–C≡C interfaces

Electrochemical green ammonia (NH3) production using renewable electricity is sustainable but suffers from selectivity-activity-stability trade-off under industrial conditions. Here we report an atomic interface engineering strategy enabling in-situ assembly and coupling of hexae...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...

How well can off-the-shelf LLMs elucidate molecular structures from mass spectra using chain-of-thought reasoning?

Mass spectrometry (MS) is a powerful analytical technique for identifying small molecules, yet determining complete molecular structures directly from tandem mass spectra (MS/MS) remains a long-standing challenge due to complex fragmentation patterns and the vast diversity of che...