Wayne State University

Infant-Toddler Court Teams and Reentry to Foster Care

Infant–Toddler Court Teams (ITCTs) are associated with higher rates of reunification and kinship permanency, but less is known about whether these gains are sustained after children exit care. This study examined reentry to foster care within 12 months of an eligible permanency e...

Predicting [177Lu]Lu-PSMA-617 SPECT/CT-based absorbed dose to whole-body tumor volume from pre-therapy [68Ga]Ga-PSMA-11 PET metrics and common blood biomarkers

It has been shown that absorbed dose (AD) to whole-body tumor volume (WBTV) from [ 177 Lu]Lu-PSMA-617 radiopharmaceutical therapy (RPT) correlates with treatment response. Pre-therapy estimation of AD to WBTV could therefore aid clinicians with patient selection and dosimetry-gui...

Waterpipe smoke condensate activates autophagy in non-tumorigenic lung epithelial cells: Implications for inflammation and stemness

Waterpipe smoking has emerged as a major global health concern, with incompletely characterized effects on bronchial epithelial cells. In this study, we investigated the cytotoxic and adaptive responses of non-tumorigenic human bronchial epithelial BEAS-2B cells exposed to waterp...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Spirituality Moderates The Relationship of Stress-Linked Psychosocial Factors To Cortisol Homeostasis and Allostatic Load Among Afro-Caribbean Women

AIM: It is hypothesized that a chronic defeat response to social or environmental stressors increases the likelihood of dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis with dysregulation of cortisol, accumulation of abdominal fat and development of glucose intoleranc...

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review

Background Complement proteins (C1q–C5) participate in immune surveillance and inflammation, but their roles in osteoblast biology and fracture healing remain generally undefined. Emerging evidence suggests that complement activation may exert both pro‑regenerative and pro‑inflam...

Accidental Toxicological Pediatric Ingestions: Disparities in the Involvement of Social Work and Child Protective Services

OBJECTIVES: To examine sociodemographic and clinical factors associated with social work consultation and child protective services (CPS) referrals among children presenting to the pediatric emergency department (ED) after an accidental toxicological ingestion. METHODS: This retr...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

“The Rio Grande Was Originally Known as Rio Bravo”: Multiliteracies in a 4th‐Grade ELA and Social Studies Project

ABSTRACT Despite the natural interdisciplinary nature of English language arts (ELA) and social studies, these two subject areas are sometimes isolated from one another in schools, including upper elementary classrooms. In this research‐in‐action article, we—two university resear...

Microbiome-Based Therapeutics in Oncology: Expanding Indications Beyond C. difficile

The intestinal microbiome has emerged as a clinically significant modulator of outcomes across multiple domains of cancer care. In hematopoietic stem cell transplantation (HSCT), loss of microbial diversity and depletion of short-chain fatty acid-producing commensals are independ...

E. coli mutant NR71 grows on succinate in the absence of an F 1 ATPase

ABSTRACT Over 50 years ago, two E. coli ATPase mutants were isolated and characterized. The first, NR70, was later shown to contain a 21-base deletion in the gene for the gamma subunit of the F 1 F 0 ATPase, rendering it incapable of growth on the nonfermentable carbon source suc...

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

Partisanship and openness to nonreligious candidates for elective office in the United States

Abstract Scholarly interest in the evaluation of atheist candidates for office has been growing. In the aggregate, atheists are a political pariah. However, aggregate effects conceal a wide partisan gulf, with Democrats more open and Republicans more averse to atheist candidates...

Surface-Retained Alginate Hydrogel Coating for Enamel Protection

Abstract Despite widespread adoption of oral hygiene routines, dental caries remains highly prevalent, affecting over 2.5 billion people globally alongside a range of associated oral diseases. As clinically established, the primary contributor to these dental conditions is the ni...

Protoporphyrin IX iron(II) revisited. overview ofthe Mössbauer spectroscopic parameters of low spin porphyrin iron(II) complexes Part II

Abstract Mössbauer parameters of low spin six coordinate [Fe(II)(Por)L 2 ] and [Fe(II)(Por)LX] complexes (where Por is PPIX or a synthetic porphyrin; L is OH − , H 2 O, a nitrogenous base, CCl 2 , CO or CN − and X is a different ligand to L) are discussed. Our point charge calcul...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...

Understanding online conversations through fractal dimension: a case study linking semantic and structural analysis of reddit posts on AI

Abstract Fractal dimension can measure the complexity of a branching structure. Botanical trees for example have more sparse branching in poor environments, and more complex branching in good environments. We hypothesize that the branching structures of online conversations can a...

Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila

Abstract Polyamine homeostasis is tightly regulated by interconversion and catabolic pathways and has been increasingly implicated in neurodegenerative disorders, including Parkinson’s disease (PD), where accumulation of α-synuclein (α-Syn) perturbs neuronal homeostasis. Spermidi...

Cyberknife radiosurgery for hemifacial spasm

Background: Surgical management of hemifacial spasm (HFS) may be contraindicated in medically unfit patients or declined because of the potential risks associated with surgery. Therefore, minimally invasive and non-invasive alternatives merit investigation. This preliminary study...