Wayne State University

Artificial intelligence in electrocardiogram interpretation for cardiovascular diagnosis and risk prediction: a systematic review of evidence through May 2026

Abstract Background Artificial intelligence-enabled electrocardiogram (ECG) analysis has expanded across cardiovascular diagnosis, monitoring, and risk prediction, but published studies vary in methodology, validation, and clinical applicability. We systematically reviewed AI app...

Three-body problems involving the mother, fetus, and microorganisms

Pregnancy is a unique immunological state in which the maternal immune system tolerates a semi-allogeneic fetus. Traditionally, this relationship has been viewed as a dyadic interaction between the mother and the fetoplacental unit. However, accumulating evidence suggests that th...

Acetazolamide Mitigates Opioid-Associated Sleep-Disordered Breathing

Rationale: Chronic prescription opioid use can exert ventilatory depression and increase loop gain to induce sleep disordered breathing (SDB). Alternative therapies to mitigate opioid-associated SDB are needed. Objective: We sought to examine whether oral acetazolamide (ACZ) will...

Neighborhood effects on Black adolescents’ obesity risk: The mediating role of family experiences

We examined longitudinal associations between neighborhood environments (walkability, area deprivation, and traffic volume) and obesity risk, tested sex differences, and evaluated family experiences as mediators. Participants were 1325 Black youth (52% male; M age = 9.5) and care...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Single-nuclei RNA sequencing reveals obesity-associated rewiring of estrogen signaling in endometrioid adenocarcinoma

Endometrioid adenocarcinoma has one of the strongest body mass index associations of any solid tumor. This is widely attributed to amplification of estrogen-driven signaling via increased production of unopposed estrogen in peripheral adipose tissue. However, there is little evid...

Convolutional LSTM surrogate for mesoscale hydrocode simulations of granular wave propagation

Granular materials subjected to impact loading exhibit heterogeneous spatiotemporal dynamics governed by stress-wave propagation, pore collapse, and grain-scale rearrangement. Mesoscale hydrocodes can resolve these mechanisms, but the computational cost of repeated simulations li...

Social Capital and Total Factor Productivity: Evidence From Plant‐Level Data

ABSTRACT Using US Census microdata, we show that ethical social norms yield measurable economic benefits. County‐level social capital, which measures cooperation and the honouring of obligations, significantly enhances plant productivity, particularly where corporate oversight is...

Racial negligence, transit, and placemaking: An examination of planning practices

Transportation infrastructure is a core component of the built environment that significantly impacts how residents access services, amenities, jobs, education, and recreation. While other facets of urban studies have begun to reckon with the wicked legacy of racialized infrastru...

Diagnostic concordance and delayed recognition: a case of atypical Kaposi sarcoma

OBJECTIVES: Accurate diagnosis depends on concordance among clinical findings, histopathologic features, and patient context; when these elements diverge, even well-characterized diseases may evade timely recognition. CASE PRESENTATION: We report a case of Kaposi sarcoma (KS) in...

Sharing the Blame: How Political Ideology Affects Reactions to Service Failures in the Sharing Economy

ABSTRACT When service failures and transgressions occur, consumers often look for someone to blame. In contexts like the sharing economy, are consumers more likely to attribute responsibility and blame to the individual gig worker or the organization? This research argues that re...

Exploring Social Determinants of Cognitive Functioning: History of Criminal Legal System Involvement and Processing Speed Among Older Black Americans

Cognitive impairment disproportionately impacts Black Americans in later life. Black Americans are also disproportionately in contact with the criminal legal system (CLS; e.g., arrest, incarceration). Emerging research indicates that CLS involvement has negative implications for...

Autonomic Nerve Fiber Compositions of Zygomaticotemporal and Lacrimal Nerves: A Cadaveric Immunohistochemical Analysis

Key Points Zygomaticotemporal (ZTN) and lacrimal nerves (LN) both carried sympathetics and parasympathetics ZTNs had more parasympathetics than LNs, but markers varied significantly within and between nerves LN parasympathetics to the lacrimal gland may mitigate dry eye after vid...

A case study reviewing the critical role of meaningful employment in brain injury rehabilitation: An occupational therapy perspective

Background Meaningful employment is essential to recovery, self-esteem, and life satisfaction for individuals with traumatic brain injuries (TBIs), particularly those who are high-functioning. Engagement in purposeful work can foster emotional and functional gains during rehabili...

Housing First or Treatment First Interventions for Mental Illness and Substance Abuse Disorders Among the Chronically Homeless? A Review of the Randomized Controlled Trial Evidence Base

The longstanding U.S. approach for treating chronically homeless people with mental illness and/or substance use disorders has been Housing First (HF): providing permanent supportive housing with wrap-around services, with no requirements on participants to engage in behavioral h...

Stress Hyperglycemia Drives CD4 + T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

ABSTRACT Perioperative stress hyperglycemia is a transient but frequent metabolic disturbance strongly linked to postoperative organ injury and mortality; however, the immunometabolic mechanisms driving this association remain largely undefined. In a two‐center cohort of patients...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Cord Blood DNA Methylation and Large-for-Gestational-Age Birth: A Pilot Epigenome-Wide Study in the GROW Cohort

Background/Objectives: Large-for-gestational-age (LGA) birth is associated with adverse perinatal outcomes and increased risk of metabolic disease later in life. Despite these risks, epigenetic studies of LGA remain limited, particularly those using umbilical cord blood DNA methy...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis

In the treatment of atrial fibrillation (AF), cryoballoon ablation (CBA) is associated with a high incidence of pulmonary vein reconnection, potentially limiting long-term efficacy. Pulsed field ablation (PFA) has emerged as a promising alternative with the potential for improved...

Emergency department management of postthrombolysis intracranial hemorrhage.

Intracranial hemorrhage following intravenous thrombolytic therapy most commonly occurs within 12 hours of administration. Because many patients remain in the emergency department during this period, a structured, time-sensitive approach to recognition and management is critical....