Wayne State University

Psychiatric and substance use disorder polygenic scores are associated with the exposome in youth

Abstract Gene-environment correlations (rGE) present challenges for accurately estimating the individual and joint contributions of genetic and environmental influences on risk for psychiatric and substance use disorders. The present study examined rGE between polygenic risk scor...

Engineering ordered two-dimensional defect phases to strengthen structural alloys

Defects in crystals are usually considered to be consequences of deformation, but they can also be engineered as strengthening features. Planar defects can strengthen structural alloys but usually form only during deformation or service, limiting control over their density, stabi...

On Poincaré surgery

Abstract We exhibit a homotopy‐theoretic proof of the fundamental theorem of Poincaré surgery in the simply connected case. We also deduce the Poincaré transversality exact sequence.

Postoperative Wound Care in Mohs Micrographic Surgery: Tradition, Variation, and the Evidence

ABSTRACT Postoperative wound care following Mohs micrographic surgery (MMS) has high variability and surprisingly limited real‐world evidence. Despite over one million MMS procedures performed annually in the United States, recommendations for topical agents, pressure dressings,...

A Blueprint for Developing a Concentration in Ambulatory Care Within the PharmD Curriculum

ABSTRACT The US healthcare system is grappling with significant challenges, notably a shortage of primary care providers. Ambulatory care pharmacists are increasingly recognized as vital contributors to addressing these challenges. The Accreditation Council for Pharmacy Education...

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in Brucella

ABSTRACT Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay. The conserved RNA degradosome scaffold, ribonuclease E (RNase E), assembles into phase-separated bacterial ribonucleoprotein bodies (BR-bodies) through its C-terminal...

Social Work as an Institution: Explaining Stability, Change, and Contradictions in the Field

This article argues for the value of studying social work as an institution. The field has long grappled with questions of professional identity and legitimacy. Yet we lack a cohesive understanding of how institutional forces have shaped social work’s development, how the field h...

Multi-Field Relaxation Dynamics of Parahydrogen-Hyperpolarized Propane Gas MRI Contrast Agent

Abstract Hyperpolarized gas-phase MRI is an emerging diagnostic modality, with the clinical utility of hyperpolarized Xe-129 gas for functional lung imaging recently supported by FDA regulatory approval. However, the requirement for dedicated multi-nuclear hardware and complex, c...

A multiomic atlas reveals distinct immune landscapes in preterm and term chronic placental inflammation

Chronic placental inflammation (CPI), an umbrella term encompassing chronic chorioamnionitis, chronic villitis, and chronic deciduitis, is associated with preterm birth (PTB), yet its cellular and molecular determinants across gestation remain poorly defined. Here, we constructed...

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Ceftaroline Diffusion Into Cerebrospinal Fluid of Children With Ventriculitis Due to Ventriculoperitoneal Shunt Infection

BACKGROUND: Data on ceftaroline cerebrospinal fluid (CSF) levels in children are limited. This study examined ceftaroline diffusion into CSF among children with ventriculoperitoneal shunt (VPS)-related ventriculitis and external ventricular drains. METHODS: Patients received a si...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

Long-Term Complications and Secondary Procedures After Open Reduction and Internal Fixation of Ankle Fractures: A Descriptive Epidemiologic Study of Over 50,000 Patients.

Background Ankle fractures account for ~10% of fractures, ~40% treated operatively, yet absolute long-horizon complication and secondary-procedure estimates by fracture pattern and comorbidity remain limited. Prior series generally left decedents in the denominator as though stil...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Phlegmonous Gastritis Refractory to Antibiotics with Subsequent Improvement on Empiric Quadruple Therapy.

Phlegmonous gastritis is a rare infection of the gastric wall that presents with nonspecific symptoms and can rapidly progress with high mortality. We report a 59-year-old woman with two days of intractable nausea, vomiting, and inability to tolerate oral intake while on chronic...

Customer Support Analysts, UX Researchers, and Directors of Storytelling: A Systematic Analysis of Job Advertisements for Anthropologists

ABSTRACT Anthropology graduates increasingly enter public and private practicing jobs. A decade ago, Brondo and Bennett argued that a disciplinary sea change was in motion that acknowledged applied work. Despite this recognition, the anthropological canon does not always address...

Max Fink (1923-2025)

Forty years after the inaugural issue of the journal Convulsive Therapy in March 1985—renamed in 1997 to The Journal of ECT —the scientific community now mourns the loss of the journal founder and first editor-in-chief, Max Fink. He was one of the world-leading experts who most v...

Clinical Practice Guideline for the Diagnosis and Treatment of Urinary Tract Infection in Children From 8 Days to 5 Years of Age

Urinary tract infection (UTI) is one of the most common bacterial infections in infants and young children, with a prevalence of 7% in infants with fever. This clinical practice guideline (CPG) provides an update of the literature and clinical recommendations of the 2011 American...

Kinetically arrested phase separation leads to tunable domain structures in vapor-deposited glasses

The characteristic length scale of phase-separated organic thin film blends is a critical structural parameter governing the performance and functionality of organic electronic devices. The arrested morphologies of vapor-deposited organic thin films result from the interplay betw...

Infant-Toddler Court Teams and Reentry to Foster Care

Infant–Toddler Court Teams (ITCTs) are associated with higher rates of reunification and kinship permanency, but less is known about whether these gains are sustained after children exit care. This study examined reentry to foster care within 12 months of an eligible permanency e...