Utrecht University

P1.238. Postoperative Outcomes in Patients After Prolonged Intensive Care Unit Stay After Esophagectomy: A Prospective Single-Center Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Prolonged intensive care unit stay (≥7 days) is common after esophagectomy. Although prolonged ICU stay after major surgery is associated with poor short- and long-term outco...

Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells

ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate thi...

Latent paths in mode choice models: incorporating street-level environment features for active travel policy

There is growing empirical evidence that walking and cycling are influenced by street-level environment features such as greenness and traffic stress. To assess active travel policy, these features are increasingly incorporated into mode choice models through predictors that aggr...

Population cycles and hydroclimatic forcing in a wetland oak population: A 1.800-year tree-ring record from the Rhine Delta

Subfossil bog oaks provide high-resolution archives of hydroecological variability in fluvial wetlands. In this study we analyse an exceptionally large dendrochronological dataset of 500 oak trunks recovered from peat deposits in the Angstel–Vecht region of the western Netherland...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Experimental mineralogical replacement to investigate the role of texture on interface morphology, reaction kinetics and pore-scale transport during metasomatism

Dolomitization is a key diagenetic process that reorganizes porosity and permeability in carbonate rocks, yet the coupling between interface kinetics and transport heterogeneity remains poorly constrained. We performed time-resolved hydrothermal dolomitization (metasomatism) expe...

Children’s Differential Susceptibility to Peer Acceptance and Rejection: A Multi-informant Longitudinal Study

In this multi-informant longitudinal study, we examined whether children with higher levels of self-reported sensory processing sensitivity (SPS) showed stronger longitudinal associations between peer relationships (i.e., peer acceptance and rejection) and their social-emotional...

Near-extremal hydrodynamics and the holographic product formula

A bstract The holographic product formula is used to determine the general form taken by holographic spectral functions in the near-extremal hydrodynamic regime, with energy ω , momentum k and temperature T much smaller than a hard scale μ . The resulting expressions simplify in...

Constructing Jacobians of rank 1

Abstract Let 𝐾 be a number field, let g ≥ 1 g\geq 1 be an integer and let f ⁢ ( x ) = ( x − a 1 ) ⁢ ⋯ ⁢ ( x − a 2 ⁢ g + 1 ) ∈ O K ⁢ [ x ] see text f(x)=(x-a_{1})\cdots(x-a_{2g+1})\in O_{K}[x] be a polynomial that splits into 2 ⁢ g + 1 2g+1 distinct linear factors. Write 𝐶 for the...

Are Attributions of Consciousness to AI Chatbots Epistemically Innocent?

Abstract Artificial intelligence (AI) chatbots (e.g., ChatGPT) can communicate in strikingly humanlike ways. This has prompted many chatbot users to attribute psychological properties, including consciousness, to these systems. However, there is little scientific evidence that cu...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Protein LanguageModel Decoys for Target Decoy Competitionin Proteomics: Quality Assessment and Benchmarks

Abstract Large-scale proteomics relies heavily on target–decoy competition for false discovery rate estimation in peptide identification, and the performance of this strategy depends strongly on the design of the decoy database. Classical generators such as reversal and shuffling...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

A review of gas leakage from the subsurface into the environment

Subsurface gas leakage represents a complex and multifaceted issue in geosciences and energy sectors. It encompasses the unintentional release of gases such as methane, hydrogen, carbon dioxide, and hydrogen sulfide from (deep) subsurface into the environment. These leakages orig...

Towards an Archaeological Workflow for SedaDNA Sample Collection: Methods and Best Practices for Minimising Surface Contamination

Sedimentary ancient DNA (sedaDNA) has been successfully recovered from diverse contexts, enabling researchers to address paleoenvironmental questions such as ecosystem changes and climatic shifts, along with archaeological questions related to past human activities, diet, health,...

Epidemiologic and genetic evidence linking peripheral neuropathy to gut dysbiosis: a systematic review

Peripheral neuropathy affects a substantial proportion of the global population and remains incompletely explained by established risk factors. Preclinical studies suggest that gut dysbiosis can modulate neuroimmune pathways and neuropathic phenotypes. However, synthesis of human...

A Dynamic Mechanism for Prevalence of Triangles in Competitive Networks

Abstract Triangles are abundant in real-world networks but rare in standard null models for sparse graphs. Existing explanations typically rely on explicit triadic closure mechanisms or geometry-based connection rules. We propose an alternative hypothesis: the frequent appearance...

An ecosyndemic framework for understanding obesity: Spatial clustering of health, environmental and socioeconomic disadvantage in the Netherlands

Abstract Introduction Obesity and related health conditions are unevenly distributed across neighborhoods, often co-occuring with multiple health challenges and socioeconomic disadvantages. Using an ecosyndemic framework, which integrates ecological and social dimensions that con...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...