University of Würzburg

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span

Abstract Background Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains...

Beta diversity of Arctiinae moths (Lepidoptera: Erebidae) along a recovering tropical forest gradient

Amid widespread biodiversity loss and alarming rates of tropical deforestation, the potential of secondary forest succession in restoring β-diversity is still widely unexplored. To investigate β-diversity along naturally recovering forests, we collected the functionally diverse g...

Electrocortical and Physiological Correlates of Memory and Attention During the Anticipation of Avoidable and Inevitable Threats

ABSTRACT When confronted with danger, humans display a range of defensive behaviors, such as freezing and active avoidance. Prior research has identified a distinct physiological response pattern to avoidable threats, characterized by heart rate bradycardia, reduced visual explor...

cGMP Signaling in Arterioles Revealed by FRET ‐Based Real‐Time Measurement in Mice In Vivo

ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time i...

How the war came to Germany — Justice, alienation and an attitude that endured, 1945–2026

Since 1 January 2026, every man born in 2008 has been liable for military screening. For this cohort, the children’s law reform of 1998 has applied from the day they were born, with a right to both parents that no child can enforce on its own. In 2026 Germany is meeting an extern...

How the war came to Germany — Justice, alienation and an attitude that endured, 1945–2026

Since 1 January 2026, every man born in 2008 has been liable for military screening. For this cohort, the children’s law reform of 1998 has applied from the day they were born, with a right to both parents that no child can enforce on its own. In 2026 Germany is meeting an extern...

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Abstract Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importa...

Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis

Endothelial dysfunction is a hallmark of pathological angiogenesis and associated with erythrocyte extravasation and lysis. Whether mediators released from lysed erythrocytes instruct endothelial cells (ECs) for new vessel formation is unknown. Here, we show that the membrane fra...

A model of evidentiary practices based on secondary students’ evaluation of media claims using complex data

Abstract The practices required to evaluate claims in the media based on mathematics and statistics are essential for informed citizenship. How the mathematical and statistical capabilities developed in school translate into these practices, however, is not well understood. In th...

Large-c BCFT entanglement entropy with deformed boundaries from emergent JT gravity

A bstract We study the effect of boundary deformations on the von Neumann entropy of subregions in two-dimensional boundary conformal field theories (BCFTs) at zero and finite temperature. The deformations considered are infinitesimal global conformal transformations that move th...

A luminal proteome of the endoplasmic reticulum and Golgi apparatus reveals a novel modulator of ER stress tolerance in African trypanosomes

African trypanosomes employ specialized mechanisms of membrane trafficking as a strategy to persist in both the mammalian host and insect vector. Their survival relies on continuous synthesis and surface delivery of extremely abundant surface coat proteins, imposing an extraordin...

Waveguide-Integrated Photonic Platform for On-Chip Optical Quantum-Dot Excitation via Electrically Pumped WGM Microlasers

Abstract We report the fabrication and characterization of an integrated quantum photonic device consisting of an electrically driven whispering-gallery-mode micropillar laser evanescently coupled to a ridge waveguide, both incorporating InGaAs quantum dots (QDs). The lasing char...

DEMETER MOVES IN MYSTERIOUS WAYS? THE NARRATIVE MOTIVATION AND TRADITIONAL ARTISTRY OF THE HOMERIC HYMN TO DEMETER

Abstract This paper reasserts that the narrative of the Homeric Hymn to Demeter is logically coherent, contrary to the common belief among scholars who often claim that the actions of Demeter herself in Eleusis are unmotivated. I argue on the contrary that the narrative of the El...

Real-world neuropsychiatric safety profile of foslevodopa/foscarbidopa infusion in advanced Parkinson's disease

Abstract Background To describe demographic, clinical, and neuropsychiatric safety outcomes in a cohort of PD patients treated with LDp/CDp infusion in a real-world setting. Methods We retrospectively analyzed a database of 77 consecutive PD patients treated with LDp/CDp at two I...

Physical contact is essential for effective social buffering of social fear in mice

Abstract Social buffering attenuates stress and fear responses, yet the sensory requirements for effectively buffering social fear remain unclear. Here, we established a paradigm combining social fear conditioning with social buffering to determine whether buffering efficacy depe...

Diving deep into uterine layers: ADC and IVIM at 0.55-T MRI

Abstract Objective To investigate and analyze the microstructure of uterine layers and to evaluate the feasibility and physiological variability of uterine diffusion metrics at 0.55-T MRI in healthy volunteers and participants with adenomyosis. Materials and methods In this prosp...

Splenic regulation of systemic platelet activation state

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defin...

Exploring spatial heterogeneity of PD-L1 and c-MET expression in oral squamous cell carcinoma

Abstract Background PD-L1 expression is an established predictive biomarker for immune checkpoint inhibitor therapy in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC). However, the spatial heterogeneity of PD-L1...

Isothiazologuanosine ( tz G) as Environmentally Sensitive Fluorescent Reporter in RNA

ABSTRACT Site‐specific labeling of RNA with emissive, structurally non‐perturbing nucleosides is critically needed for probing RNA structure, dynamics, and function. Isothiazolopyrimidine‐based nucleoside surrogates are leading examples of fluorescent RNA building blocks, with th...

Cytomegalovirus Latency Fuels Inflammation Following Myocardial Infarction

BACKGROUND: Epidemiological studies have consistently associated cytomegalovirus (CMV) seropositivity with adverse cardiovascular outcomes. However, the mechanisms by which cytomegalovirus infection impacts pathophysiology in the heart remain poorly understood. In this study, we...