University of Würzburg

Tales of destruction and repair: the changing view of MYC proteins in tumorigenesis

MYC proteins are classically viewed as oncoproteins because they act as DNA-bound transcription factors that drive characteristic gene expression programs. Building on this view, recent work has shown that MYC proteins engage in multiple protein complexes that resolve transcripti...

Deep learning recognises antibiotic modes of action from brightfield images

Abstract Antimicrobial resistance is a growing public health threat predicted to cause up to 10 million deaths a year by 2050. To circumvent existing bacterial resistance mechanisms, discovering antibiotics with novel modes of action (MoAs) is crucial. While growth inhibition ass...

Fully automated pipeline for localization and scoring of rheumatic disease related regions and pathologies in hand MRI

Rheumatic diseases constitute a major cause of chronic pain, functional impairment, and long-term disability worldwide. In rheumatic diseases, reliable assessment of structural damage and inflammatory activity is essential for diagnosis, disease monitoring, and treatment response...

OpenMRF : A Modular, Vendor‐Neutral Open‐Source Framework for Magnetic Resonance Fingerprinting Using Pulseq

ABSTRACT Purpose Widespread adoption and methodological advancement of magnetic resonance fingerprinting (MRF) are limited by the lack of unified, reproducible implementation frameworks and fragmented open‐source tools. To address these barriers, we introduce OpenMRF—a comprehens...

Video‐Assisted Versus Conventional Surgical Informed Consent in Visceral Surgery—A Cluster Quasi‐Randomized Clinical Trial

ABSTRACT Background Comprehensive informed consent is a core surgical responsibility but is increasingly challenged by rising patient volumes and limited personnel resources. Digital solutions in healthcare offer opportunities to optimize patient education. Video‐assisted informe...

Distinct lattice and charge excitations in AV3Sb5 kagome superconductors

The kagome superconductor family A V 3 Sb 5 ( A = Cs, Rb, K) provides a rich platform for exploring diverse electronic symmetry breaking phenomena, including superconductivity and various forms of density wave orders. Although these compounds share the identical lattice structure...

Host‐to‐Pathogen Transfer of Neutrophil Components via Extracellular Vesicles Shields Candida albicans From Immune Attack in Human Blood

ABSTRACT Neutrophils effectively eliminate Candida albicans from human blood, but a subset of fungal cells escapes clearance and remains extracellular and viable. Here we show that this evasion is independent of known immune‐escape traits of C. albicans . Instead, neutrophil‐deri...

Time-resolved energy-share reconstruction of individual glycolytic flux kinetics reveals duration-dependent bias in elite sprint cycling

Abstract Background Maximal lactate accumulation rate (vLamax) is commonly used as a surrogate of anaerobic glycolytic power. Conventional protocols calculate vLamax as a mean rate over a fixed sprint window after subtracting an alactic phase, even though glycolytic flux rises, p...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

MoCaNLO: a Monte Carlo integrator for NLO calculations

Abstract We present the Monte Carlo integration code MoCaNLO, which computes cross sections and distributions for processes at high-energy colliders like the LHC at leading and next-to-leading order (NLO) in the strong and electroweak couplings. It relies on the Recola package fo...

Sexual dimorphisms in mechanisms of pressure natriuresis

Aim: The renal pressure-natriuresis response defines the blood pressure set point and maintains circulating volume. In male rats, the mechanisms involve trafficking and inactivation of renal proximal sodium transporters. Mechanisms may differ in females due to sex differences in...

Dispersion‐Clamped Crystalline Supramolecular Columnar π‐Stacks of Adamantyl‐Substituted Pyrenes

ABSTRACT Despite their importance in supramolecular chemistry, zero‐offset columnar π‐stacks of polycyclic aromatic hydrocarbons (PAHs) are rarely observed in crystals because close cofacial packing is penalized by Pauli repulsion. Here we show a crystalline phase (CP) of adamant...

Nonlinear OrderSeparation in Two-Dimensional ElectronicSpectroscopy Quantifies Properties of Higher-Excited States

Abstract Two-dimensional (2D) spectroscopy combines high temporal and spectral resolution, allowing the observation of ultrafast energy transfer and the separation of homogeneous and inhomogeneous broadening. Typically, 2D spectroscopy is dominated by the lowest-order nonlinear s...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Identifying the scale of effect of habitat for diversity and biomass of multiple arthropod taxa

Abstract Context Understanding how landscape composition influences biodiversity is a central objective of landscape ecology. Because species respond to environmental conditions across different spatial scales, landscape effects are inherently scale-dependent, making the identifi...

Assessing Linguistic and Content Characteristics of First-Grade Students’ Texts Using Generative AI

The present study examines how accurately a common large language model (ChatGPT 5.0) assesses linguistic and content characteristics of texts written by first-grade students. The focus is on the consistency of LLM assessments and their alignment with human assessments. The datab...

Frequency of therapeutic drug monitoring in inpatient precision depression care and duration of hospitalization

Abstract In psychiatry, therapeutic drug monitoring (TDM) is routinely used to improve treatment safety and efficacy, yet its association with hospitalization duration and cost-effectiveness remains unclear. We hypothesized that the frequency of routinely requested TDM is associa...

Common thought patterns reflect generosity, fairness, and social context

Abstract Humans generate thousands of thoughts each day, many of which concern other people. Yet it remains unclear whether these ongoing thoughts vary systematically across social contexts that demand meaningful social behavior, and whether they reflect individual differences in...