University of Utah

Protocol for identifying cellular and molecular signatures from spatial profiling data using micro-tissue analysis

Spatial tissue profiling measures hundreds to thousands of biomolecules across tissue regions, but most analyses examine each feature one at a time. Here, we present a protocol for micro-tissue analysis using partial least-squares modeling. We describe steps for stratifying regio...

When confident eyewitnesses are mistaken: a mixture model account for the confidence-accuracy relationship

An influential claim suggests that highly confident identifications have a very high probability of being accurate when police use scientifically validated best practices for identification procedures. However, there are exceptions. Using simulation data, we demonstrate that when...

Passing Cerclage Wires Through a Direct Anterior Approach in Total Hip Arthroplasty: Surgical Technique

Passage of cerclage wires, either for prophylactic stability or for intraoperative fracture fixation, is a commonly used technique in total hip arthroplasty. However, the same techniques for wire placement cannot be used regardless of approach. In the direct anterior approach, co...

Structure of Li3YCl6 and Its Effect on Lithium Ionic Conductivity

Abstract Halide-based Li+ solid-state electrolytes have garnered renewed interest in recent years, mainly because of their significantly improved Li+ ionic conductivity and excellent stability against high-voltage cathodes. Numerous studies have reported that synthetic conditions...

Exposure to chemotherapy alters secondary drug sensitivity without genomic alterations in patient-derived ovarian cancer organoid models

Ovarian cancer has significant morbidity and mortality due to high rates of resistance to chemotherapy and recurrence. Our objective was to deploy patient-derived organoid (PDO) models of ovarian cancer to assess secondary drug sensitivity after exposure to chemotherapy in vitro....

Genomic and Transcriptomic Correlates of Deep PSA Response in Patients with Metastatic Androgen Pathway Modulation-Sensitive Prostate Cancer

Abstract Background Despite advances in metastatic androgen pathway modulation-sensitive prostate cancer (mAPMS) treatment, outcomes remain heterogeneous. Achieving a post-treatment undetectable prostate specific antigen (PSA) is a strong prognostic marker. We aimed to identify g...

EARLY OUTCOMES OF NEW CEMENTLESS TOTAL KNEE ARTHROPLASTY DESIGN: A RETROSPECTIVE COHORT ANALYSIS

Background Cementless total knee arthroplasty (TKA) has gained interest due to potential benefits in biologic fixation and long-term durability. This study compared early outcomes among cementless TKA performed with robotic assistance, cemented TKA performed with robotic assistan...

Global Burden of Pediatric Stroke (1990–2023): A Shift From Mortality Toward Disability

BACKGROUND: Pediatric stroke is a significant cause of long-term disability worldwide, with outcomes influenced by age, stroke subtype, and access to care. Our objective was to define the global burden of pediatric stroke by its impact on mortality and disability. METHODS: The Gl...

Diastereo- and Enantioselective Photobiocatalytic α-Alkylation of α-Heteroaryl Amines Enabled by Pyridoxal Photochemistry

Abstract We report a photobiocatalytic system for the enantio- and diastereoselective α-alkylation of α-heteroaryl amines, a largely underexplored class of synthetically valuable non-native amine donors. Evaluation and directed evolution of thermophilic threonine aldolases, enabl...

Long-Term Prosthesis Survival After Total Hip Arthroplasty in Young Women with Developmental Dysplasia of the Hip: A Narrative Review of Instability, Revision Risk, and Reproductive Health Considerations

Background/Objectives: Total hip arthroplasty (THA) reliably improves pain and function, but implant longevity in women aged ≤50 years is influenced by longer duration of implant use and distinct failure mechanisms. Developmental dysplasia of the hip (DDH) is a common underlying...

Limits to the Hall Effect and Other Nonreciprocal Effects in Three‐Dimensional Metamaterials

ABSTRACT Metamaterials can exhibit exotic nonreciprocal properties, yet corresponding fundamental limits and design blueprints achieving them are largely unexplored. Here, we derive comprehensive bounds on the effective nonreciprocal properties of three‐dimensional metamaterials...

Accuracy and Disparities in Pediatric Emergency Triage: A Multicenter Retrospective Cohort Study

OBJECTIVES: To assess the accuracy of the Emergency Severity Index (ESI) in correctly stratifying high-risk pediatric patients and predicting resource use across multiple pediatric emergency departments (EDs), and to identify patient and environmental factors associated with tria...

Sex Disparity in Enrolment to Clinical Trials for Onchocerciasis and Trachoma

To determine whether female enrolment in randomized interventional clinical trials for onchocerciasis and trachoma reflects the real-world sex distribution of disease burden, and to evaluate sex-based differences across trial characteristics. We performed a cross-sectional analys...

Suzetrigine for Postoperative Pain in Head and Neck Free Flap or Transoral Robotic Surgery

Importance Postoperative pain after head and neck surgery frequently necessitates opioid analgesia despite multimodal pain regimens. Suzetrigine, a selective NaV1.8 inhibitor that was recently approved in the US for acute postoperative pain, may reduce postoperative opioid requir...

Filling the void: Template prototyping through frontal polymerization

A promising reactive manufacturing method is frontal ring-opening metathesis polymerization (FROMP), which is characterized by a self-sustaining exothermic polymerization cascade that autonomously transforms bulk monomer resin into polymer materials. Here, we demonstrate a straig...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

Temporal Dynamics Between the Three Dimensions of Meaning in Life and Well-Being among Chinese College Students: Coherence as Prerequisite, Purpose as Connector, and Significance as Outcome

Abstract The three-dimensional model of meaning in life conceptualizes meaning as comprising coherence, purpose, and significance, yet how these components relate to one another over time and how they jointly connect to subjective well-being and global meaning appraisals remains...

Antibiotic Selection for Sustained Local Therapy May Be Important to Reduce Pseudomonas aeruginosa Dominance Against Staphylococcus aureus and Bone Response Modulation in an Ovine Polymicrobial Fracture-Related Infection Model

Polymicrobial fracture-related infections (FRIs) underpinned by bacterial biofilms pose therapeutic challenges distinct from those of monomicrobial infection, as interspecies dynamics may alter both antimicrobial response and host tissue injury. This study evaluated systemic and...

Association of Community Factors, Firearm Laws, and Pediatric Firearm Injuries

OBJECTIVE: To conduct a zip code-level analysis of community measures and firearm legislation associated with pediatric fatal and nonfatal firearm injuries, ordered by strength of association. METHODS: This was an ecological study of 46 states and the District of Columbia from Ja...

Machine Learning-Guided Scope Selection to Balance Performance and Substrate Similarity

Abstract The determination of a reaction substrate scope enables downstream users to assess whether a specific transformation is suitable for an intended application. The information content of this scope, characterized by its performance and structural diversity, is crucial to e...