University of Utah

Effects of one night of sleep deprivation on single- and dual-task gait

Abstract Sleep deprivation (SDEP) impairs cognitive control, which may affect movements that rely on these processes, such as walking. To test whether gait changes after one night of SDEP reflect reduced cognitive capacity, we compared its effects with those of dual-task walking...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Prognostic implications of complications during VA-ECMO for cardiogenic shock

PURPOSE: Veno-arterial extracorporeal oxygenation (VA-ECMO) provides comprehensive cardiopulmonary support in patients with cardiogenic shock (CS), but may result in complications. While complications rates are known, their impact on risk of death remains largely unknown. METHODS...

The longitudinal co-development of adverse childhood experiences and child internalizing problems: Examining sociodemographic disparities

Abstract Internalizing problems are prevalent in childhood and are associated with exposure to adverse childhood experiences (ACEs); however, their co-development across childhood remains understudied. Prior research documents sociodemographic disparities (i.e., race/ethnicity, s...

Functional seizures: care experiences of U.S. Veterans and their care partners

Functional seizures (FS) present substantial diagnostic and treatment challenges, particularly for Veterans with multiple medical and psychiatric comorbidities including post traumatic stress disorder, mood disorders and traumatic brain injury. To more effectively care for Vetera...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

From DEF - A long poem

DEF starts from the seed of a sentence by Gottlob Frege: “On the introduction of a name for something simple, a definition is not possible; there is nothing for it but to lead the reader or hearer, by means of hints, to understand the words as is intended.”1 I replaced each word...

Sound and Complete Solving for Multi-width Parametric Bitvectors via Principled Reductions

Bitvectors are foundational for automated reasoning about programs, and fixed-width bitvector solvers (QF_BV) are fast and ubiquitous. However, the theory of parametric bitvectors (PBV), where widths are symbolic, is much less well understood. The theory of multi-width PBV, where...

Accurate Residues for Floating-Point Debugging

Floating-point arithmetic is error-prone and unintuitive. Floating-point debuggers instrument programs to monitor floating-point arithmetic at run time and flag numerical issues. To do so, they estimate residues—the difference between actual floating-point and ideal real values—f...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Provably Lossless Acceleration of DNN Mutation Testing via Memoization

Mutation analysis has recently reemerged in the context of deep neural networks (DNNs) as a promising, but notoriously costly, approach for assessing test dataset adequacy. Existing techniques speed up DNN mutation testing through lossy approximations that trade efficiency for mu...

Navigating a Synthetic Visual Health Information Environment: Implications of Photorealistic Generative Artificial Intelligence for Public Health.

. 2026;116(10):1539-1549. https://doi.org/10.2105/AJPH.2026.308675).

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Semantics for 2D Rasterization

Rasterization is the process of determining the color of every pixel drawn by an application. Powerful rasterization libraries like Skia, CoreGraphics, and Direct2D put exceptional effort into drawing, blending, and rendering efficiently. Yet applications are still hindered by th...

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

Abstract Objective The ketogenic diet (KD) is a high-fat, low-carbohydrate intervention widely used to treat drug-resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota-dependent mechanisms. Additionally, recent studies suggest...

Homeostatic Turnover, Repair, and the Demographic Form of Haldane's Principle

Haldane's principle relates equilibrium mutation load to deleterious mutational input rather than to selection strength. We study this balance in a homeostatically regulated, damage-structured population where mutation occurs during reproduction, repair restores individuals towar...

Growth of aromatic hydrocarbon dust particles in the extremely metal-poor galaxy Sextans A

The mid-infrared spectrum of star-forming, high-metallicity galaxies is dominated by emission features from aromatic and aliphatic bonds in small carbonaceous dust grains, often referred to as polycyclic aromatic hydrocarbons (PAHs). In metal-poor galaxies, the abundance of PAHs...

Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements

Abstract Introduction and Hypothesis Uterus preservation is increasingly used for uterovaginal prolapse (U-POP) repair despite ongoing concerns regarding future uterine, cervical, and adnexal pathology. We evaluated incidental pathology rates, associated risk factors, and created...

Clinical impact of stage-specific central sensitization-related symptoms in hip osteoarthritis secondary to acetabular dysplasia

Abstract This study aimed to compare the characteristics of central sensitization (CS)-related symptoms between mild and severe hip osteoarthritis (OA) secondary to acetabular dysplasia and to clarify their associations with hip pain. A total of 116 patients with unilateral hip O...

Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways

BACKGROUND: Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applicatio...