University of Utah

3D seismic imaging of a fracture damage zone controlling reservoir compartmentalization at the Raft River EGS using multi-azimuth walkaway VSP

Accurate imaging of steeply dipping fracture zones in crystalline enhanced geothermal systems (EGS) is critical for constraining permeability architecture and guiding stimulation design. However, such structures remain poorly resolved by conventional surface seismic methods. We p...

Curve fitting algorithm for multimodal particle size distributions – a theoretical basis

Abstract. Here we detail an open-source curve fitting algorithm for multimodal particle size distributions (MPSDs) and evaluate it against a ten-year dataset of ambient particle size distribution (PSD) measurements collected at Storm Peak Laboratory, a remote mountainous research...

Unifying Observations, Simulations, and Theory for Drizzle Size Distribution Tails

Abstract The onset and rate of drizzle remain open problems in atmospheric physics. This study brings together theory, simulations, and observations to analyze the emergence of power‐law tails in droplet size distributions as a signature of a dynamic steady state with coalescence...

Optimizing culture-free approaches to recover high-quality Mycobacterium tuberculosis genomic variation

Background. Mycobacterium tuberculosis ( Mtb ) genomic epidemiology often relies on culturing patient sputum, a time- and labour-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant i...

Functional Multireference Alignment via Deconvolution

Abstract. This paper studies the multireference alignment (MRA) problem of estimating a signal function from shifted, noisy observations. Our functional formulation reveals a new connection between MRA and deconvolution: the signal can be estimated from second-order statistics vi...

Neuralgic Amyotrophy Following Rotator Cuff Repair

Neuralgic amyotrophy (NA) is an uncommon but potentially debilitating cause of pain and weakness that is felt to be inflammatory in nature. This patient-focused case report describes the experience of a 64-year-old active male who developed severe periscapular pain eight days aft...

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Ovarian high-grade serous carcinoma (HGSC) is an aggressive ovarian cancer with a heterogeneous tumor microenvironment (TME). Advances in single-cell RNA sequencing (scRNA-seq) and spatially-resolved transcriptomics have enabled the study of complex TME. This study explores conne...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Variation in In-Hospital Emergency Transfer Rates Across Pediatric Hospitals

BACKGROUND: Clinical deterioration with late escalation, termed emergency transfer (ET), is a key safety metric. However, national benchmarking is limited by variable definitions. We sought to estimate pooled ET rates and assess variation across pediatric hospitals. METHODS: We p...

Development of a Tool to Assess Competency in Bronchoscopic Lung Volume Reduction Via Endobronchial Valve Placement

RATIONALE: Bronchoscopic lung volume reduction (BLVR) is an established treatment option for severe emphysema, improving lung function and quality of life. Despite its growing use, there are no standardized, validated tools to assess operator competency in performing BLVR, limiti...

Layered Development of Visual Search Expertise in Architects

It is widely proposed that perceptual expertise is characterized by an increased reliance on peripheral visual information during search, as described by Holistic Visual Processing (HVP) theory. HVP predicts that experts make longer saccades to construct a holistic representation...

Photoacoustic Tomography with Time-Dependent Damping: Theoretical and a Convolutional Neural Network-Guided Numerical Inversion Procedure

Abstract. In photoacoustic tomography (PAT), a hybrid imaging modality that is based on the acoustic detection of optical absorption from biological tissue exposed to a pulsed laser, a short pulse laser generates an initial pressure proportional to the absorbed optical energy, wh...

A Survey of Distributed Asynchronous Many-Task Models and Their Applications

Asynchronous many-task (AMT) runtime systems have become an important paradigm for expressing fine-grained parallelism and managing asynchrony in high-performance computing (HPC). Originating from early dataflow concepts, AMTs have evolved to enable dynamic task generation, expli...

From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails

Abstract New genes and gene functions are key drivers of evolutionary innovation. Venomous animals, such as cone snails, provide striking examples of gene innovation, yet the mechanisms by which toxins arise remain poorly understood. Using the Conus textile genome, we uncover how...

Polynomial-Augmented Neural Networks (PANNs) with Weak Orthogonality Constraints for Enhanced Function and PDE Approximation

Abstract. We present polynomial-augmented neural networks (PANNs), a novel machine learning architecture that combines deep neural networks (DNNs) with polynomial expansions. PANNs combine the strengths of DNNs (flexibility and efficiency in higher-dimensional approximation) with...

A Pull-Apart Strategyfor Synthetic Rifamycins

Abstract A practical synthetic strategy for the preparation of rifamycin analogues has been developed, enabling access to the first compound modified at the critical enol ether–ketal linkage with demonstrated antimicrobial activity. Leveraging a deconstruction strategy, the rifam...

Design of heat treatment and magnetic field-assisted machining for microstructure and surface corrosion control in Inconel 718

It has been demonstrated that Magnetic Field-Assisted Machining (MAM) has strong potential for improving surface quality and tailoring microstructure in hard-to-machine heat-treatable Inconel 718 (IN718). However, the influence of MAM on corrosion performance of IN718, particular...

Outcomes of Aseptic, Septic, and Occult Infected Index Nonunion Repair: A Retrospective Comparative Study

OBJECTIVES: To compare nonunion surgery effectiveness for occult infected, aseptic, and septic nonunions in patients identified using the FRI criteria. METHODS: Design: Retrospective Review Setting: Single Level I Tertiary Academic Center Patients Selection Criteria: All skeletal...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications

Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...