University of Ulsan

GRP78/BiP as a novel midbody component induces mitotic exit failure via PLK1 stabilization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and is associated with a poor prognosis, even when diagnosed in its early stages. Therefore, identifying novel HCC targets for therapeutic drug development is critically needed. Our pr...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Per Protocol Analysis and Long‐Term Outcomes of Laparoscopic Radical Resection for Gallbladder Cancer Compared With Open Method

BACKGROUND: Although laparoscopic radical resection for gallbladder (GB) cancer has been attempted, only a limited number of studies have evaluated its outcomes using a per-protocol analytical approach. METHODS: Between January 2010 and December 2019, 213 patients underwent surge...

Targeting CDK7 to overcome hypomethylating agent resistance in acute myeloid leukemia

Abstract Purpose Hypomethylating agents (HMAs), such as azacitidine and decitabine, are widely used in elderly or medically unfit patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). However, most patients eventually develop primary or acquired resistance...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Safety and Effectiveness of Intramuscular Dexmedetomidine Versus Per-Rectal Thiopental for Pediatric Brain Computed Tomography Sedation: A Retrospective Cohort Study.

OBJECTIVES: Following per-rectal thiopental (PR-THP) supply discontinuation, a tertiary pediatric emergency department in Korea transitioned to intramuscular dexmedetomidine (IM-DEX) for brain computed tomography (CT) sedation. We evaluated the safety and effectiveness of this pr...

Long-term follow-up results of topical imiquimod for high-grade cervical intraepithelial neoplasia in young women: an original research

<title>Abstract</title> Background As cervical excisional treatment is associated with adverse pregnancy outcomes, imiquimod has been explored in several studies—such as the TOPIC-3—as an alternative but without success. Therefore, we designed a study focusing on patients aged &l...

Polynucleotides Attenuate Atopic Dermatitis-like Inflammatory Signaling in Keratinocytes and Macrophages

Background: Atopic dermatitis (AD) is a persistent and recurring skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and elevated expression of proinflammatory mediators. We investigated the anti-inflammatory potential of polynucleotides (PN), highl...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Prenatal PM2.5 exposure drives epigenetic reprogramming of fetal macrophages linked to atopic dermatitis

Abstract Prenatal environmental exposures are increasingly recognized as contributors to atopic dermatitis (AD), yet the underlying mechanisms remain unclear. Fine particulate matter (PM 2.5 ), a complex mixture of airborne pollutants, has been associated with elevated risk of al...

Repositioning of cis-flupentixol for the suppression of ovarian cancer cell migration and invasion through ERK5 inhibition

Ovarian cancer (OC) remains the most lethal gynecological malignancy, largely because of its late-stage diagnosis and limited effective screening modalities. Despite therapeutic advances, high relapse rates and therapeutic resistance—particularly in metastatic disease—underscore...

Plasma Metabolomes Identify Distinct Asthma Metabotypes: Findings From the COREA Cohort

BACKGROUND: Phenotype-based asthma classification has limitations that have motivated endotype-based approaches grounded in pathophysiology. However, existing biomarkers offer limited specificity and clinical accessibility. Plasma metabolomics, which reflects disease-specific met...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS)

Abstract Background The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to in...

Phenotyping Sepsis at Emergency Department Presentation Using Early Clinical Data: A Multicenter Cohort Study

Background: Sepsis is heterogeneous, and early emergency department (ED) management is constrained by limited information and dynamic clinical trajectories. Methods: Using the nationwide Korean Sepsis Alliance (KSA) registry, we applied k-means clustering to nine routine ED varia...

Selective Neurectomy and Masseteric-to-Zygomatic Nerve Transfer With Processed Nerve Allograft for Postparalytic Ocular Sequelae: Preliminary Results

Oro-ocular synkinesis is a debilitating sequela of facial nerve injury. While selective neurectomy (SN) offers a surgical alternative to botulinum toxin, its efficacy is often limited by recurrence. This study evaluates the feasibility and preliminary results of combining targete...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...