University of Ulsan

Susceptibility‐Guided Triple Therapy Achieves High Helicobacter pylori Eradication Regardless of Duration

ABSTRACT Background and Aim Although clarithromycin resistance is a major cause of empirical triple therapy failure for Helicobacter pylori eradication, the clinical relevance of amoxicillin susceptibility remains uncertain. We first compared eradication outcomes between empirica...

Simulation-based multi-objective resource optimization in fog computing using Genetic Algorithms

Efficient task scheduling in heterogeneous fog computing environments remains a challenging problem because latency, energy consumption, and resource utilization are inherently conflicting optimization objectives. Conventional scheduling techniques often rely on static heuristics...

Operationalizing Nitrogen Compliance: A Leakage-Safe, Alarm-Budget Framework for Wastewater Treatment Early Warning

Abstract We developed a leakage-safe, alarm-budget framework for early warning of effluent total nitrogen (TNout) in a municipal wastewater treatment plant (WWTP) using multiyear daily records from Ulsan, Republic of Korea. The framework combined strict temporal feature construct...

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial

Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...

Distinct immune inflammatory markers and proteomic signatures underlying psoriasis with pruritus

Pruritus is a common and burdensome symptom in patients with psoriasis, yet its underlying systemic mechanisms are not sufficiently defined. To characterize systemic immune-inflammatory profiles and serum proteomic differences associated with pruritus in patients with psoriasis a...

Contrasting Prognostic Value of Discordance Between Resting Distal-to-Aortic Coronary Pressure Ratio and Fractional Flow Reserve in Coronary Artery Disease

BACKGROUND: Discordance between nonhyperemic pressure ratios and fractional flow reserve (FFR), observed in up to 20% of cases, complicates clinical decision-making for coronary revascularization and warrants further investigation of its clinical implications. This study aimed to...

Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering

BACKGROUND: Current necrotizing enterocolitis (NEC) diagnostic criteria fail to capture the full spectrum of intestinal injury. We aimed to identify diagnosis-independent clinical patterns of intestinal injury among vulnerable very low birth weight (VLBW) infants using unsupervis...

Eliminating Texture‐Induced Retention of Self‐Assembled Monolayer Residues for High‐Performance Perovskite Solar Cells

Self-assembled monolayers (SAMs) constitute foundational interfacial elements in high-efficiency inverted perovskite solar cells (PSCs); however, ensuring chemical and electronic integrity across SAM-modified interfaces remains challenging. Although post-deposition solvent washin...

Cumulative Local and Metachronous Recurrence Rates in Patients with Ulcerative Colitis-Associated Neoplasia after Endoscopic Submucosal Dissection

Background/Aims: Endoscopic submucosal dissection (ESD) has emerged as a curative alternative for ulcerative colitis-associated neoplasia (UCAN), particularly when endoscopic mucosal resection is not feasible for complete resection. This study aimed to evaluate cumulative inciden...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Ultrahigh Detectivity Colloidal Quantum dot Avalanche Photodetectors Driven by Electron Mobility of the n‐Type Layer

ABSTRACT Colloidal quantum dots (CQDs) are pragmatic candidates for infrared photodetectors due to their high absorption coefficient in the infrared region and solution processability. In addition, an incorporation of avalanche multiplication within the CQD region offers a route...

Comparison of Uncovered and Covered Biliary SEMS for the Salvage of Obstructed SEMS: A Multicenter Retrospective Propensity Score–Weighted Study

BACKGROUND AND AIMS: Recurrent biliary obstruction (RBO) is common after uncovered self-expandable metal stent (UCSEMS) placement in unresectable distal malignant biliary obstruction. We compared stent patency, clinical outcomes, and RBO patterns between fully covered (FCSEMSs) a...

Paradoxical prognosis of extracellular vesicle-derived miR-4435 expression in advanced colorectal cancer

Abstract Extracellular vesicle (EV)-derived microRNAs are promising non-invasive biomarkers for colorectal cancer (CRC), but their stage-specific prognostic significance remains unclear. We evaluated circulating EV-derived miR-4435 and its target TIMP3 in a retrospective cohort o...

Estimating Parkinson’s disease finger tapping severity from RGB videos using a temporal–statistical–spectral feature fusion framework

Parkinson’s disease (PD) is characterized by progressive motor impairment, and finger tapping is widely used in the MDS-UPDRS (Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale) to assess bradykinesia. However, clinical scoring is limite...

Reducing contact resistance in wire-mesh-integrated flow fields via welding to improve PEMFC performance

Metal wire mesh flow fields enhance reactant transport in polymer electrolyte membrane fuel cells (PEMFCs), but insufficient mesh-bipolar plate contact can increase ohmic loss. This study investigated spot welding to reduce this interfacial resistance. Four configurations were ev...

Electrical injection of meron-antimeron pairs into a magnetic domain wall

Topological spin textures, such as merons and antimerons, have garnered significant attention for their potential in spintronic devices due to their inherent topological stability. However, achieving precise electrical control over these topological textures has remained challeng...

Arthroscopic partial meniscectomy should be performed carefully for medial meniscus tear with the anteromedial meniscofemoral ligament

The clinical relevance of the anteromedial meniscofemoral ligament (AMMFL) in medial meniscus (MM) tears remains unclear. This study investigated whether arthroscopic partial meniscectomy (APM) for MM tears with AMMFL is associated with joint degeneration. Among 2568 patients who...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Chronic Subdural Hematoma in the Super-Aged Society: From a Traumatic Curiosity to a Self-Perpetuating Vascular-Inflammatory Disease

Chronic subdural hematoma (cSDH) was traditionally regarded as a simple mechanical consequence of head trauma, treated by burr-hole drainage alone. Recent ultrastructural, histopathological, and clinical evidence has reframed cSDH as a chronic, self-perpetuating disease driven by...