Institution
University of Turku
Recent research
- Materials & EnergyOpen access
Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core
ABSTRACT Selective RNA cleavage could provide versatile options in therapeutic applications. In this study, multivalent RNA‐cleaving agents, featuring 1,5,9‐triazacyclododecane or guanidine groups as catalytic centers, were synthesized on a cubic octameric silsesquioxane (COSS) c...
- Health & MedicineOpen access
Abstract Background This longitudinal designed study evaluated the impact of systemic isotretinoin use on oral health-related quality of life (OHRQoL) through its effects on clinical periodontal parameters, salivary flow rate, and patient-reported oral symptoms. Methodology Twent...
- BiologyOpen access
Abstract Background Sentinel lymph node biopsy (SLNB) is the standard method for axillary staging in breast cancer. To ensure the identification of sentinel lymph nodes (SLNs), lymphoscintigraphy (LS) is often used. However, failure of LS remains a clinical challenge. A second tr...
- Health & MedicineOpen access
Abstract Radical cystectomy (RC), preceded by platinum-based neoadjuvant chemotherapy (NAC), is recommended for eligible patients with muscle-invasive bladder cancer (MIBC). Although NAC improves survival, many patients do not respond; in non-responders, it may delay surgery and...
- Climate & EnvironmentOpen access
Abstract Microplastics represent an emerging threat to freshwater ecosystems. However, their seasonal deposition patterns in lake sediments remain poorly understood due to low number of studies, conflicting results and methodological inconsistencies. This study presents the first...
- Health & MedicineOpen access
Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...
- Health & MedicineOpen access
Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...
- BiologyOpen access
The Invisible Web: Linking Diet and Gut Microbiota Across Time and Space in Odonates
Abstract The complex relationship between insects and their gut microbiota has become a central theme in host–microbe ecology, revealing profound effects on host fitness and interactions. Yet, how gut microbial communities—and their primary determinant, diet—vary across space and...
- Health & MedicineOpen access
Intracapsular tonsillectomy in adults with obstructive sleep apnoea and large tonsils
PURPOSE: Conventional (extracapsular) tonsillectomy is a well-established treatment for obstructive sleep apnoea (OSA) in adults with tonsillar hypertrophy. Our objective was to determine whether an intracapsular tonsillectomy (ICTE) with a 90% removal of tonsils could be suffici...
- Health & MedicineOpen access
BACKGROUND: Neonatal mortality remains high in low‑ and middle‑income countries, where early postnatal care (PNC) within 48 hours can avert many deaths. Yet neither the national coverage of newborn PNC nor the factors associated with its receipt have been assessed. OBJECTIVES: We...
- Society & EconomicsOpen access
Background Co-teaching refers to instruction jointly planned and implemented by two or more teachers to achieve shared learning goals. It supports multidisciplinary learning and the development of students' collaboration skills. Although co-teaching is used in nursing education,...
- Engineering & TechnologyOpen access
Abstract This work presents an experimental workflow coupled with statistical tools to optimize L-DED processing parameters to build defect-free AlSi10Mg multilayer parts. Experimental steps included the quantitative evaluation of single beads, single layers, and multilayers to d...