University of Turku

Porous and Permeable Crystalline Basement: Evidence for Large‐Scale Hydraulic Connectivity at Kivetty, Finland

Abstract Porosity and permeability in crystalline shield basement are commonly assumed to be low, yet some fault zones sustain fluid circulation over kilometer scales. Here we quantify multiscale fault‐zone connectivity at Kivetty, central Finland, by integrating legacy deep‐bore...

Risk factors for external apical root resorption in orthodontics: the role of treatment modalities and tooth-related conditions

External apical root resorption (EARR) is a multifactorial and often irreversible complication observed during orthopaedic and fixed appliance treatment. This study aimed to identify possible risk factors for orthodontically induced EARR and to determine whether there is an incre...

The associations between mental health symptoms and cognitive and social functioning among school-aged children from diverse migration backgrounds

Abstract Background Mental health symptoms may be linked to cognitive and social functioning in school-aged children, but less is known about whether these associations differ across migration-background groups. Methods We examined cognitive, social, and mental health measures am...

Spin-disc misalignment drives periodic accretion and pulse profile asymmetry in X-ray pulsars

Abstract We investigate magnetospheric accretion in disc-fed X-ray pulsars assuming that the neutron star spin axis is not perpendicular to the disc plane. We focus on X-ray pulsars, where a geometrically thin disc is truncated far from the stellar surface the channelled part of...

Applicability of Online Course for Teaching Diagnostic Criteria for Temporomandibular Disorders ( DC / TMD ) Axis I in Undergraduate Dental Education–Interexaminer Reliability Between Students and Teachers in a Student Exercise

ABSTRACT Introduction Temporomandibular disorders (TMDs) are common conditions affecting the masticatory system, causing pain and dysfunction. The DC/TMD Axis I protocol is increasingly included in undergraduate dental curricula. Aim To evaluate the applicability of a DC/TMD Axis...

Modeling the Subglacial Sediment System of the Finnish Lake District Ice Lobe During Deglaciation

Abstract. The systematic connection of glacial conditions in ice models with subglacial geomorphological observations has been limited by an inability to model subglacial sediment processes. The Finnish Lake District Ice Lobe (FLDIL) presents an opportunity to apply new model app...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Georges Ifrah, Lucien Gerschel, and four as the limit of small number systems

In his popular book Universal History of Number Georges Ifrah gives several examples of small number systems. Ifrah uses them as evidence of the idea that small number systems have a limit of four and count: one, two, two-one, two-two, many. The sources and origins of Ifrah’s hyp...

Depolarization ratio of smoke and volcanic ash aerosol particles at 1565 nm using a HALO Doppler lidar

Abstract. Particle linear depolarization ratio is a widely used parameter in lidar research to distinguish different aerosol types and the thermodynamic phase of water. It is most frequently measured at ultraviolet and visible wavelengths (355 and 532 nm), yet multi-wavelength ob...

Refining genetic circuit design for enhanced type II polyketide biosynthesis in Escherichia coli

Polyketides represent a broad class of structurally diverse natural products with potent antibacterial and anticancer activities. Type II polyketide synthases (T2PKS) are multi-subunit complexes responsible for condensing acylated intermediates, including acetyl-CoA and malonyl-C...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Longitudinal associations between sleepiness and sleep disturbances across pregnancy

OBJECTIVE: Although sleep disturbances increase during pregnancy, sleepiness does not appear to follow a similar trajectory. Given that the relationship between sleep disturbances and sleepiness during pregnancy is understudied, we examined their associations to determine whether...

The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), a condition marked by inflammation and fibrosis that increases the risk of cirrhosis, liver failu...

Machine learning-based prediction of morphophysiological, ionic, and biochemical responses of Lolium multiflorum to salinity stress

Salinity is a major constraint on the establishment and productivity of annual ryegrass ( Lolium multiflorum Lam.). This study evaluated the effects of NaCl stress on the germination, growth, mineral composition, and biochemical responses of four annual ryegrass cultivars (‘Grass...

Longitudinal dynamics of serum IL-33 and sST2 across age and sex in a healthy Finnish cohort before and after Tdap booster vaccinations

Background Interleukin-33 (IL-33) and soluble ST2 (sST2) are critical regulators of tissue-derived inflammation, and their dysregulation is usually implicated in various inflammatory disorders. Despite this, how these circulating proteins behave over time in healthy individuals r...

Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays...

The Effect of Repeated Bilateral Deep Parasternal Intercostal Plane Catheter Boluses on Analgesia After Cardiac Surgery: A Randomized Controlled Trial

BACKGROUND: Median sternotomy for cardiac surgery is associated with significant postoperative pain. We evaluated whether repeated ropivacaine boluses via bilateral deep parasternal intercostal plane (DPIP) catheters improve analgesia after cardiac surgery. METHODS: In this rando...

Pathogens in the Nasopharynx Before and After Antibiotic Treatment for Acute Otitis Media

BACKGROUND: Limited data exist on whether the timing or duration of treatment for acute otitis media (AOM) affects nasopharyngeal carriage. We studied the eradication of pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) in relation to timing (...

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

ABSTRACT Aim To characterise multi‐kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage‐specific taxonomic and functional alterations using shotgun metagenomic sequencing. Materials and Methods In this cross‐sectional study, 204 adu...