University of Turin

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

European Association of Palliative Care White Paper on research priorities for family caregiving in palliative care: A systematic review of reviews

BACKGROUND: Family carers are central to providing high quality palliative care. However, gaps remain in our understanding of how best to support carers. In 2010, the European Association for Palliative Care published a White Paper on 'Improving Support for Family Caregivers'. Th...

Brief communication: Shared parameterisation for estimating snow water equivalent through cosmic ray neutron sensors in the Italian Alps

Abstract. We present a novel approach based on leveraging a shared parameterisation to derive snow water equivalent (SWE) with cosmic ray neutron sensing (CRNS) probes. The network comprises 26 sites (1422–2901 ma.s.l.) in the Italian Alps. The parameterisation was defined by fit...

Surgical Ablation for Atrial Fibrillation During Minimally Invasive Mitral Valve Surgery: Risk Dependencies and Long-Term Survival

Objective: Atrial fibrillation (AF) is a common finding among patients with mitral valve disease, with a growing body of evidence showing survival benefits associated with surgical ablation (SA). However, a lack of data persists regarding the safety and survival after SA concomit...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Carbon neutrality targets and optimal policy: a multicriteria analysis

Purpose This study explores how public policy and individual behavior interact to achieve carbon neutrality targets, aiming to identify the optimal incentive structure that balances short-term mitigation costs and long-term sustainability goals. Design/methodology/approach A dyna...

Effects of previous crop residues management through strategic tillage and fungicide application on the agronomic traits and the mycotoxin contamination of wheat

Background The retention of crop residues on the soil surface may increase the risk of Fusarium head blight (FHB) and mycotoxin contamination in wheat ( Triticum aestivum ) grains. Objective This study aims to evaluate the effects of reduced tillage systems (no-tillage or minimum...

Atomistic Origin of Structural, Vibrational, and Electronic Fingerprints in Iminopyridine Iron(II) Dichloride Complexes

Abstract Density functional theory (DFT) investigations were performed on a diverse library of iron(II) dichloride complexes bearing iminopyridine (ImPy) ligands to establish robust structure–property relationships governing their electronic and vibrational behavior. The pronounc...

Compatibility and Implication from a Non-Classical Perspective

Abstract This paper draws attention to key logical relations between two distinct and independently intelligible notions, compatibility and implication . We identify a set of inference rules governing compatibility and show how crucial principles concerning conditionals can be de...

Descriptive Form for Geosite Inventory in the Context of the Regional Law for Geoheritage in Piemonte (NW-Italy)

Abstract On the occasion of the first UNESCO International Geodiversity Day (October 6th, 2023), the Piemonte Region Council promulgated the Regional Law “Provisions for the conservation, management and valorisation of the geological heritage”. This legislative measure recognises...

Unravelling the Enantiomeric Distribution of Key Sandalwood Sesquiterpenoids by Enantioselective Gas Chromatography and Molecular Rotational Resonance

Abstract The enantiomeric distribution of α- and β-santalol in various Santalum and Osyris species of different origins was determined by the combination of enantioselective gas chromatography and chiral tagging molecular rotational resonance spectroscopy, supported by the prepar...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Maternal Loneliness and Technoference During Early Childhood: The Mediating Roles of Nomophobia and Social Media Addiction

Maternal technoference has increasingly been recognized as a factor that may compromise mothers’ emotional availability and the quality of mother–child interactions, particularly during early childhood, when responsive caregiving and co-regulation play a pivotal role in children’...

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology

BACKGROUND AND AIMS: Peritoneal metastases (PMs) represent the most frequent, clinically challenging dissemination pattern in advanced gastric cancer, especially poorly cohesive (PCGC) subtype, and are associated with poor prognosis. We aimed to characterize the transcriptomic la...

p-adically convergent loci in varieties arising from periodic continued fractions

Abstract Inspired by the existence of multiple alternative definitions of continued fraction expansions for elements in $$\mathbb {Q}_p$$ Q p , we study the p -adic convergence of periodic continued fractions with partial quotients in $$\mathbb {Z}[1/p]$$ Z [ 1 / p ] from a geome...