University of Turin

How can prospective life cycle assessment support the eco-design of an innovative battery-grade lithium carbonate production process?

The transition to low-carbon energy systems drives increasing lithium demand, making alternative recovery technologies essential for long-term supply resilience. This study shows how eco-design principles guide the identification of the most environmentally-friendly configuration...

Leading Humanistic Transformation of Business, Economy and Society: Lessons From Olivetti’s Blueprint

Building on the core pillars of Humanistic Management–dignity, ethics, and legitimacy–this study examines how these principles were enacted across organizational, community, and societal levels, and how Humanistic Leadership translated a normative vision of business into concrete...

From environmental burden to resource potential: environmental impact evaluation and Critical Raw Materials recovery from abandoned gold mining waste in the Western Alps (NW Italy)

Extractive waste (EW) from former mining activities poses long-term environmental impacts while representing a potential secondary resource. Within a circular economy framework, EW can be valorised to recover raw materials (RMs) and critical raw materials (CRMs) contributing to t...

The anti-GPC1 antibody AT101 as effective targeting agent for chemotherapeutic-loaded chitosan nanobubbles in the treatment of pancreatic adenocarcinoma

Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan considered as useful target for pancreatic adenocarcinoma (PDAC) treatment being specifically and highly expressed on PDAC cell surface. Here, we proposed AT101...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

RNAmotifs 2.0: a framework for inferring multivalent RNA motifs and their candidate regulators of splicing

Alternative splicing expands proteomic diversity and is shaped by RNA‑binding proteins (RBPs) that bind to multivalent RNA motifs. Yet connecting cis-acting motifs to their candidate trans-acting protein remains difficult from sequence information alone. Here we present RNAmotifs...

Lantern bearers and beavers: ecosystem engineers foster abundance of fireflies along European rivers

Abstract Insect declines are among the most pressing biodiversity issues of our time, with consequences for ecosystem functioning and human well-being. Fireflies (Coleoptera: Lampyridae) are emblematic insects, whose populations are declining worldwide due to habitat alteration,...

Real-world Italian experience with asciminib in chronic myeloid leukaemia–chronic phase: case series and drug profile overview

Abstract Asciminib selectively targets the myristoyl pocket of ABL1, offering high specificity and a potentially improved safety profile. Its efficacy has been demonstrated in both clinical trials and real-world settings, including heavily pretreated patients and those with T315I...

Gender equality and labour market liberalisation: empirical evidence from the E.U.

Abstract Labour markets are responsible for large part of the levels of gender inequality present in the world and many countries enacted liberal reforms of their labour markets since the 1980s. The present empirical analysis aims at understanding their impact on gender inequalit...

Growth of small localised perturbations in surface quasi-geostrophic turbulence

The butterfly effect, namely the amplification of an initially localised infinitesimal perturbation, is a fundamental hallmark of chaotic systems. While this phenomenon is well understood in low-dimensional chaotic systems, its implications become more complex in spatially extend...

Comparative Prognostic Value of AFP, PIVKA-II, and GPC-3 in Hepatocellular Carcinoma: A Real-World Multicenter Cohort Study

Background/Objectives: The current cornerstone for prognostic hepatocellular carcinoma (HCC) stratification is the Barcelona Clinic Liver Cancer (BCLC) score, which integrates tumor and liver function staging but lacks tumor biology parameters. Serum tumor biomarkers, such as alp...

Beyond optimisation: Revisiting energy demand management

Energy demand reduction (EDR) in households has re-emerged as a central pillar of climate and energy transition strategies in Europe and beyond. While energy efficiency has long dominated policy frameworks, growing evidence shows that efficiency alone is insufficient to achieve a...

Natural course of dermatophytosis-compatible lesions and clinical response to a single-dose Trichophyton verrucosum vaccine in intensively reared veal calves: a longitudinal field study

Bovine dermatophytosis is common in young cattle, especially in intensive veal-calf systems, yet large-scale longitudinal field data remain limited. Therefore, this study investigated the natural course of dermatophytosis-compatible lesions and the clinical response to a single-d...

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Integrated internal standard volumetric dried blood microsampling for the quantification of phosphatidylethanol 16:0/18:1

Phosphatidylethanol 16:0/18:1 (PEth) is a direct biomarker of alcohol consumption, formed in red blood cell membrane in the presence of ethanol. Concentrations of 20 ng/mL and 200 ng/mL have been proposed as cut-offs to distinguish abstinence or low alcohol consumption from moder...

Delusion of Pregnancy: An Updated Systematic Review

Delusion of pregnancy (DoP) is a rare psychopathological symptom characterised by the fixed, delusional conviction of being pregnant in the absence of objective evidence. The systematic review by Bera and Sarkar remains, to this day, the principal quantitative reference on the ph...

Some Remarks on Singular Capillary Cones with Free Boundary

Abstract We study singular minimizing capillary cones with free boundary. We provide a stability criterion à la Jerison–Savin and use it to prove that a minimizing capillary cone is flat when its free boundary mean curvature is non-negative and $$n\le 4$$ n ≤ 4 , or non-positive...

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

Extending women's health-span is a key challenge for the medical community. Although women live longer than men, they face a higher burden of chronic diseases, such as cardiovascular diseases (CVDs) and disabilities. Endogenous estrogens appear to benefit cardiovascular health, a...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

“Uroboros” circle: a multilevel study on leader–follower and follower–leader crossover

Purpose The literature on the crossover theory (Westman, 2001) typically focuses on how leaders influence followers’ well-being by exchanging psychological states and resources (Hobfoll et al., 2018). However, the role of followers in influencing leaders’ well-being has been less...