University of Turin

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

Clinical exit strategy in anti-VEGF therapy for neovascular AMD: incidence of recurrence and risk factors for relapse

PURPOSE: To evaluate the recurrence rate of neovascular activity after discontinuation of intravitreal anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (AMD) and to identify baseline clinical and imaging factors...

Cardiac Complications of Infections Due to Respiratory Syncytial Virus and Human Metapneumovirus: A Systematic Review and Pooled Analysis of Clinical Features

Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are major causes of respiratory tract infections across different age groups. Although primarily regarded as respiratory pathogens, both viruses have been associated with cardiac complications, whose clinical spec...

MICROLOCAL ANALYSIS, TIME-FREQUENCY TRANSFORMS AND LOCAL UNCERTAINTY PRINCIPLES

In this paper we propose an uncertainty principle of local type involving the short-time Fourier transform in the frame of ultradifferentiable spaces.The classical local uncertainty principle for the Fourier transform can be seen as a refinement of the Heisenberg inequality; the...

Beyond monospecificity in systemic lupus erythematosus: Emerging roles of bispecific and trispecific antibodies

Purpose Targeted biologic therapy has changed the management of systemic lupus erythematosus (SLE), including lupus nephritis (LN), but incomplete response, relapse, glucocorticoid dependence, and refractory organ disease remain common. This article discusses whether bispecific a...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Inclusion Complexes Between α-Cyclodextrins and Xenon: Molecular Dynamics Simulations and Experimental Study

Xenon (Xe) is an inert noble gas receiving increasing attention in medical research due to its anesthetic properties, ability to regulate metabolic processes, and broad organoprotective effects. Due to its small size and non-covalent intermolecular interactions, Xe can be encapsu...

Drug Permeation Dataset Across Diverse Chemical Space Using PermeaPad and High-Throughput Plate Reader Assays

Abstract Purpose High-throughput permeation assays are essential tools in drug discovery for identifying small molecules with favorable permeability, yet quantifying their transport kinetics across biomimetic membranes often relies on resource-intensive chromatographic methods. H...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...

Therapeutic Drug Monitoring of Antifungal Agents: Toward Harmonization of Therapeutic Ranges

Background: Invasive fungal infections are associated with high morbidity and mortality, particularly among immunocompromised and critically ill patients. Antifungal therapy is complicated by substantial pharmacokinetic variability, drug–drug interactions, and narrow therapeutic...

Diagnostic Performance of Source-Recorded Food-Specific Prick-by-Prick Testing Against Oral Food Challenge Outcomes: A Challenge-Selected Single-Center Retrospective Study

Oral food challenge (OFC) is the reference standard for diagnosing IgE-mediated food allergy, whereas the performance of prick-by-prick testing (PbP) with native foods in routine care is uncertain. We retrospectively screened all food-specific OFC records from 2 January 2024 to 6...

From Selective Adsorption to Photocatalytic Removal: Complementary Cobalt Oxides for Pollutant-Oriented Treatment of Dye Mixtures

The development of photocatalysts for water treatment generally focuses on maximizing removal efficiency, whereas the role of material–pollutant interactions in determining pollutant-dependent removal behaviour remains comparatively underexplored. Herein, pristine Co3O4 and a CuC...

Sudden Unexpected Perinatal Death Due to Undiagnosed Diffuse Placental Chorioangiomatosis

Chorioangiomatosis is a rare placental vascular disorder that may lead to severe fetal compromise and, in exceptional cases, sudden perinatal death. Its prenatal diagnosis remains challenging because diffuse lesions may lack a discrete placental mass and escape routine ultrasonog...

A quantitative methodology for analysing physical damage and recovery dynamics from concurrent and consecutive hazards: forensic insights from Puerto Rico

Space and time play a crucial role in multi-hazard impact assessment. When two or more natural hazards occur simultaneously or in sequence at the same location, the physical integrity of assets and infrastructures can be compromised, and the resulting damage can be greater than t...

‘Something Entirely Contingent’: Hermann Cohen’s Already Relativized A Priori

Abstract Among current endeavours to historicize Kantianism, two prevailing approaches are frequently discussed: Reichenbach’s ‘constitutive, but relative a priori ’ and Cassirer’s ‘regulative, but absolute a priori ’. This paper argues that this opposition is misleading, as it f...

Is time dilation ‘real’? Einstein and the transverse Doppler effect

Abstract As early as 1907, Einstein realized that the second-order transverse Doppler redshift reported by Stark in the spectral lines of fast-moving ions in canal rays could serve as a direct experimental test of time dilation. He rejected Stark’s dynamical explanation of the ef...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

Contested Liberalisms in Mexico: Popular Liberalism, the Fourth Transformation, and the Struggle over Constitutional Identity

Mexico's Cuarta Transformación (4T) is usually read as one instance of a global illiberal turn. This article argues instead that the Mexican constitutional conflict is internal to the liberal-republican tradition: rival projects each claim the mantle of liberalism to define who c...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...