University of Southern Denmark

Uncovering pan-cancer signatures of chemoresistance

Abstract Background Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types. Metho...

Lumbar MRI findings in the recumbent and the upright position: a prospective observational study on type and frequency of differences by direct comparison

Recumbent MRI is the most widely used image modality in people with low back pain; however, it has been proposed that upright (standing) MRI has advantages over recumbent MRI because of its ability to assess the effects of being weight-bearing and thus, potentially add clinically...

Using the Vaquita's Acoustic Behavior to Strengthen Priority Conservation Areas

ABSTRACT The vaquita ( Phocoena sinus ) is an endemic porpoise restricted to the upper Gulf of California, Mexico, with a total range of 4048 km 2 . Using expert elicitation, the number of vaquitas detected in and near the Zero Tolerance Area—a 288 km 2 area within the Vaquita Re...

Measuring child and adolescent behavior in outdoor play environments: a survey among researchers exploring quantitative research methods

Abstract Background Outdoor play environments are essential for children’s and adolescents’ development, making it crucial to understand how to measure their use effectively. This study focuses on quantitative methods, which are well suited to capturing the frequency, intensity,...

Phenotypic manifestations and variant reclassification of germline PTEN variants: a nationwide Danish study

Background Classification of heterozygous germline PTEN variants in patients with, or suspected of having, PTEN hamartoma tumour syndrome (PHTS) remains challenging. Accurate classification is essential as these patients require lifelong cancer surveillance. Methods We identified...

Disease-activity-linked complement-coagulation interactions and persistent platelet activation in treatment-naïve systemic lupus erythematosus

Background Thrombosis is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although multiple prothrombotic pathways have been identified, most have been studied individually or after treatment initiation. We aimed to characterize interactions between...

Longing for More than People: A Cultural and Historical Dialogue for Understanding Loneliness and the Built Environment

As loneliness is a concern for many, both due to its associations with adverse health outcomes and due to its, by definition, negative connotations for the individual, it is important to identify ways to address it. The built environment may be one such way. The aim of this conce...

Can ICD‐11 Personality Disorder Trait Dimensions Be Categorically Specified?

ABSTRACT The new ICD‐11 Personality Disorder (PD) classification introduces a global severity classification (i.e., mild, moderate, and severe) of personality dysfunction, which may be further accompanied by up to five trait domain specifiers delineating individual manifestations...

Initiating School-Based Health Programs: Management Perspectives from the Generation Healthy Kids Study

Abstract Effective implementation of school-based health program depends on successful pre-implementation, which may influence program adoption, delivery, and outcomes. Despite its importance, pre-implementation remains underexplored. The Generation Healthy kids (GHK) study exami...

Insecurity and policy preferences: how economic and physical threats shape attitudes toward social welfare and criminal justice

Despite frequent portrayals of the current political situation as an “age of insecurity”, we still know very little about the effects of insecurity on policy attitudes. In this paper, we explore the effect of economic and physical insecurity on two key policy domains: social welf...

Probing Strong Coupling in Core–Shell Nanoparticles With Fast Electron Beams

Collective optical excitations, such as localized surface plasmons in metallic nanoparticles and Mie resonances in high‐index dielectrics, play a central role in nanoscale light–matter interactions. When interacting with electronic transitions in matter, they can couple strongly,...

Cross-platformization: How U.S. right-leaning media curate their posts on Twitter and Truth Social

This study examines how seven right-leaning media organizations utilize cross-platformization strategies to reach audiences across multiple platforms; in this case, Twitter and Truth Social. Focusing on both content volume and story packaging, we collect right-leaning media organ...

“Not only standing for, but standing up for diversity”: an intersectional qualitative analysis of how university students embody and resist discrimination

Abstract Background Universities are key social institutions that shape student health, wellbeing, and future trajectories. However, they are also embedded in, and contribute to, existing social inequities. Students holding marginalised positions consistently report experiences o...

Greater D3-Creatine Muscle Mass and MRI Thigh Muscle Volume are Associated with Higher Bone Strength in Older Adults: Exploratory Findings in The Study of Muscle, Mobility and Aging (SOMMA)

Abstract Low bone mineral density (BMD) and impaired bone strength are established risk factors for fractures in older adults. Decreased muscle size also contributes to fracture risk, however, the relationship between muscle size and bone density, microarchitecture, and strength...

Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progression and Resistance Through Supplement Therapy

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited treatment success and strong resistance to therapy. Natural killer (NK) cells are important immune cells that can destroy cancer cells, and their function can be improved through certain micronutr...

Interlocking plate compared with conventional pin fixation for undisplaced femoral neck fractures: a randomized controlled trial with radiostereometric analysis

Aims: In undisplaced femoral neck fractures, fixation failure remains a concern. In vitro studies suggest that interlocking plates increase torsional stability. However, whether this leads to clinically relevant improvement in fixation stability in vivo remains unclear. According...

Artificial intelligence and ultra-high performance computing methods and experiments for drug discovery: virtual screening, deep learning, molecular dynamics simulations, ADMET modelling, and experimental validation

Recent years have witnessed considerable progress in computer-aided drug discovery, driven by the incorporation of computational technologies within both academic and pharmaceutical environments. This evolution is marked by a significant accumulation of data pertaining to detaile...

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

On Propositional Dynamic Logic and Concurrency

Dynamic logic is a powerful approach to reasoning about programs and their executions, obtained by extending classical logic with modalities that can express program executions as formulas. However, the use of dynamic logic in the setting of concurrency has proved problematic bec...

Intermediate habitat fragmentation reduces gastropod movement in experimental intertidal landscapes: implications for fragmentation–diversity relationships

Abstract Context Understanding how habitat configuration influences biodiversity is central to landscape and seascape ecology, yet experimental tests that isolate fragmentation per se from habitat area remain rare. In an earlier experiment that disentangled the effects of habitat...