University of Southern Denmark

Truncated ErbB2 receptor expression lowers nucleus stiffness and increases migration of breast cancer cells

The mechanisms underlying mechanical differences among cancer cell lines with varying metastatic potential remain poorly understood, despite their clear therapeutic relevance. While comparisons between malignant and benign cell mechanics reveal systematic differences, these are d...

Quantitative Susceptibility Mapping‐Based Characterization of Lesion Heterogeneity in Multiple Sclerosis

ABSTRACT Background Quantitative susceptibility mapping (QSM) characterizes multiple sclerosis (MS) lesions through susceptibility changes related to iron and myelin. However, the prevalence, regional distribution, and relationship of QSM‐defined lesion subtypes with choroid plex...

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024...

The historical development of sample size estimation: from Huygens and Bernoulli to the present

This paper traces the historical development of frequentist sample size estimation from its philosophical origins to its present-day complexity. Preliminary concepts were identified by Christiaan Huygens’ work on expected value and Jacob Bernoulli’s law of large numbers , which f...

Process measures developed for the routine monitoring of low-value care with electronic health data: A scoping review

Background Low-value care (LVC) are medical services where the potential harms or costs outweigh expected clinical benefits. Despite growing adherence to initiatives such as Choosing Wisely, approaches to routinely monitor and reduce LVC across healthcare systems remain limited....

Globalization of Perturbative Chern–Simons Theory on the Moduli Space of Flat Connections in the BV Formalism

Abstract We study the perturbative path integral of Chern–Simons theory (the effective BV action on zero-modes) in Lorenz gauge, expanded around a (possibly non-acyclic) flat connection, as a family over the smooth irreducible stratum $${\mathcal {M}}'\subset {\mathcal {M}}$$ M ′...

Vitamin K 2 and D 3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE Trial

BACKGROUND: Coronary artery calcification (CAC) progression is a strong predictor of cardiovascular events. We investigated whether supplementation with vitamin K 2 and vitamin D 3 reduces CAC progression in patients with severe coronary calcification. METHODS: In this multicente...

A Multi-Study Evaluation into Generative Artificial Intelligence for Test-Driven Development

Test-Driven Development (TDD) is an agile practice that alternates writing failing (unit) tests (Red phase), implementing production code that makes failing tests pass (Green phase), and improving the code through the Refactor phase. TDD promises better external and internal qual...

Lessons from the Danish Vascular (DanVasc) pilot survey: patient-reported outcomes following lower extremity, carotid and aortic artery disease

Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...

Stock- and stress-informed design and fabrication of load-bearing structures from reclaimed timber

Abstract The structural reuse of reclaimed timber is limited by material heterogeneity, unknown provenance, and the absence of reliable grading procedures. This paper introduces an integrated data-driven design, engineering, and fabrication framework that systematically transform...

Activity and participation after transient ischemic attack: a scoping review

Transient ischemic attack (TIA) is traditionally regarded as a condition with full recovery. However, emerging evidence suggests that some individuals experience residual symptoms, limiting their activity and participation in everyday life. The objective was to systematically map...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Development of national consensus-based recommendations for history taking, examination and clinical management of infants in chiropractic practice

Abstract Background Chiropractors in many countries provide care for infants, yet few structured, evidence-informed recommendations exist to guide history taking, examination, and clinical management in this population. In Denmark, variation in practice and limited public underst...

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...

Efficient Calculation of Absorption Spectra of Platinum Complexes Used as Luminescent Probes for Cancer Detection

Despite major advances in oncology, many chemotherapeutic agents still cause severe side effects that reduce quality of life, motivating new approaches for early detection and targeted elimination of cancer cells. Luminescent transition metal complexes are promising biomolecular...

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide

PURPOSE: It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investig...

The Effect of CEO Narcissism on the Quality of Environmental, Social, and Governance Reporting—Evidence From Listed German Companies

ABSTRACT This study explores how CEO narcissism—a salient individual trait within the upper echelons of corporate leadership—shapes the quality of environmental, social, and governance (ESG) reporting in large German firms. Drawing on data from 109 DAX, MDAX, and SDAX companies b...

The Long Road With Infective Endocarditis: Patients' Experiences of Long‐Term Hospitalisation and Treatment—A Qualitative Study

BACKGROUND: Infective endocarditis requires long-term antibiotic treatment, often involving a lengthy hospitalisation. These extended stays frequently lead to patients experiencing feelings of isolation from their daily lives, which can result in loneliness and concerns for their...

Frequent Callers to Emergency Medical Services: an observational cohort study from Region Zealand, Denmark (2018–2025)

Frequent callers to Emergency Medical Services represent a small group of citizens who account for a substantial number of calls. Despite their impact, little is known about their characteristics and patterns of EMS use. This study aimed to examine frequency, dispatch outcomes, a...

Challenges in deep learning-based small organ segmentation: A benchmarking perspective for medical research with limited datasets

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern CNNs, a Vision Transformer, and foundat...