University of Southern Denmark

Walking for Chronic Pain: Why It Matters, What We Know and How to Get Started: A Position Paper From the European Pain Federation ( EFIC ) ‘On The Move’ Task Force

ABSTRACT Background Physical activity is a cornerstone of chronic pain management. However, translating general recommendations into practical, clinically meaningful guidance for people living with chronic pain and their healthcare providers remains challenging. Walking represent...

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials

Abstract Objective To compare the effect of specific antidepressants with placebo on heart rate corrected QT interval (QTc) during the first eight weeks of treatment for major depressive disorder in adults, and to investigate whether antidepressant use is associated with early ma...

Mini-breaths and vocal-fry-like laryngeal register alleviate respiratory constraints on tokay ( Gekko gecko ) mating vocalizations

Geckos are among the few non-avian reptiles that use acoustic signals for territorial defence, mate attraction and distress signalling. Although previously considered inflexible, male tokay geckos exhibit vocal plasticity by switching to longer, louder call types in noisy environ...

Reporting of suspected adverse drug reactions: a systematic review comparing clinical settings and pharmacovigilance systems

Abstract The proportion of suspected adverse drug reactions (ADRs) that are formally reported to official pharmacovigilance databases is unclear, although this is essential for patient safety. This systematic literature review aimed to compare the level of formal reporting of ADR...

Post-Post-API Age: Studying Digital Platforms in Scant Data Access Times

Over the past decade, data provided by digital platforms has informed substantial research in HCI to understand online human interaction and communication. Following the closure of major social media APIs that previously provided free access to large-scale data (the “post-API age...

Use of Ibuprofen Before and in Early Pregnancy Among Women With and Without Chronic Medical Diseases. A Cross‐Sectional Study

PURPOSE: While having a chronic medical disease (CMD) increases use of analgesics and anti-inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in early pregnancy among women with and without...

Conditional gender gaps in welfare state support: The role of labor market and household inequality

Abstract Why are women more supportive of the welfare state than men? Existing literature on this attitudinal gender gap focuses mainly on how men and women, on average, experience varied risks in the labor market. Feminist scholarship argues that the welfare state has the potent...

Diagnostic accuracy & clinical importance of AI confidence for extremity fracture detection: 2,508-patient retrospective cohort

PURPOSE: To estimate diagnostic performance of a deep learning algorithm for extremity fracture detection on radiographs in patients aged ≥ 2 years using a refined reference standard. Secondary, to compare positive predictive value (PPV) by the algorithm's built-in confidence lev...

Leg Muscle Assessment by HR-pQCT and DXA: Associations Between Imaging Measures and Muscle Function in Adults with Obesity – A Pilot Study

Abstract Dual energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) are used for bone assessment but also image adjacent soft tissue. This pilot study examined association between HR-pQCT-measured leg muscle cross-sectional ar...

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone remains limited. Objective Given the role of the gut microbiome in disease progression, we evaluated whether gut metagenomic profiles are associated with 90-...

Oral health and oral microbiota composition in patients with Parkinson’s disease: a case‒control study

Introduction Parkinson’s disease (PD) is associated with motor and non-motor dysfunctions that may influence oral homeostasis. An altered microbiota has been linked to PD, yet oral microbial changes remain poorly characterized. This case‒control study aimed to determine if the or...

Electrooptic Reflective Metasurfaces for Discrete Beam Deflection

Abstract Dynamic, electrically controlled optical metasurfaces are essential flat-optics components that are intensively being developed for realizing compact beam steering, optical modulation, and programmable wavefront control. In this work, we propose a novel metasurface conce...

Influence of Polydopamine as a Green Passivating Layer on Organic-Based Photoelectrodes via Ex Situ Transfer

Abstract Photoelectrochemical (PEC) water splitting for renewable fuel production has recently witnessed remarkable progress. Organic semiconductor photoanodes stand at the forefront due to their numerous advantages, such as a wide absorption coefficient, tunable energy levels, a...

Global incidence of chronic lymphocytic leukemia: A systematic review and meta-analysis

Background Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a slow-growing cancer, which requires substantial resources for monitoring and management. CLL is most common among older people; however, there is a lack of understanding of its incidence in some reg...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Investigating the persistence of iron-bound phosphorus in lake sediment under sulfidic conditions

Abstract Iron (Fe) additions are widely used to suppress internal phosphorus (P) loading in eutrophic lakes by promoting the formation of vivianite (Fe(II) 3 (PO 4 ) 2 ·8H 2 O), a redox-stable Fe–P mineral that can sequester P in anoxic sediments over the long term. However, vivi...

Neuroradiologic Findings in Patients With S CN2A Disease

SCN2A disease spans a broad clinical spectrum from self-limited (familial) neonatal-infantile epilepsy to severe developmental and epileptic encephalopathies. Systematic characterization of the spectrum of neuroradiologic abnormalities in SCN2A disease has not been performed. Thi...

The Democratic Cost of Pursuing Virality: A Study into Parliamentary Communications

The transformation of parliamentarians into media producers has heightened concerns about emerging forms of political communication. This mixed-methods paper examines the strategies they employ to enhance their digital presence. Based on in-depth interviews, it shows that Brazili...

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport

The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL's key role in neuronal function. Many actions of CHL are stereospecific, as shown by differences from its 3 α -hydroxy epimer, epicholesterol (epiCHL). How this minor stru...