University of Southern Denmark

Brief video-feedback training enhances childcare professionals’ interaction skills: A cluster randomized controlled trial

High-quality caregiver–child interactions are central to children’s development in early childhood education and care (ECEC) settings. Professional development programs have been shown to improve caregivers’ interactional skills, but evidence from large randomized controlled tria...

Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

In this study, we sought to comprehensively map ubiquitin signaling networks at the crossroads of cellular proliferation and proteostasis, both crucial in cancer. Genome-wide CRISPR knockout screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whos...

Building charisma and trust with prosodic constructions

Abstract The present paper uses a perception experiment to investigate which prosodic factors determine the perceived charisma and trustworthiness conveyed by phrase-final intonation contours. The following factors were manipulated using PSOLA resynthesis and combined into 16 sti...

How Long Do Wealth Shocks Persist? Less Than Three Generations in England, 1700–2026

ABSTRACT What happens across generations to wealth shocks? Do they endure and even magnify, or do they dissipate? By implication, how much modern wealth is attributable to events before 1900? This paper uses random shocks to family size in England before 1880 that created wealth...

Predicting Climate Adaptation Intention and Collective Climate Action

Abstract: Individual adaptation to climate hazards (e.g., create an emergency plan) and collective climate action (e.g., participate in a protest) arises from the interplay of numerous variables. Traditional linear models often fail to capture this complexity. This study employed...

Time trends in patients with ulcerative colitis and crohn’s disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis – a nationwide cohort study

BACKGROUND AND AIMS: Most patients with Crohn's disease (CD) or ulcerative colitis (UC) receive medication at diagnosis, but some do not. We examined 25-year trends in the proportion of newly diagnosed IBD patients not receiving any pharmacologic treatment within one or three yea...

Development and Validation of a Blood Test Informed Risk Prediction Model for Lung Cancer—The Copenhagen Lung Cancer Risk Model (CPH-Lung)

Purpose Lung cancer screening reduces lung cancer mortality, but identifying high-risk individuals remains difficult. We wanted to develop a blood test–based risk model (CPH-Lung) to improve risk stratification before image-based screening. Materials and Methods We included indiv...

Six guidelines for trustworthy, ethical and responsible automation design

Abstract Calibrated trust ( Lee and See 2004 ) is critical for safe and seamless integration of automated systems into society. 1 Users should only rely on a system recommendation when it is actually correct and reject it when it is factually wrong. This requires an accurate trus...

Multi‐Scale 3D Printing of Magnetic Polymer Nanocomposites with Controlled Particle Dispersion and Hyperthermic Response

ABSTRACT The ability to encode well‐defined physical properties and spatiotemporally controlled responses into multifunctional nanocomposites is enabling a new generation of advanced responsive systems. We describe the synthesis of magnetic nanoflowers (NFs) and their full disper...

Sustainable iodine contrast media for a healthy future (SUSTAINED): a global survey of practice

Abstract Objectives To investigate healthcare professionals’ knowledge, attitudes, and practices (KAPs) of the environmental impact and sustainability of iodinated contrast media (ICM). Materials and methods A cross-sectional web-based survey was distributed to members of profess...

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and met...

The youth sport specialization paradox: A think tank consensus to translate research into actionable evidence-based practice

Scientific evidence shows that early sport specialization is neither necessary nor beneficial for achieving elite performance and may harm athletes’ long-term success, health, and well-being. Yet, accelerated youth sport practices remain widespread, creating what we term the yout...

Domain-Selective Enhancement of Second Harmonic Generation in Monolayer MoS2 via Ferroelectricity-Controlled Photodoping

Abstract Hybrid heterostructures combining two-dimensional semiconductors with ferroelectric materials offer a versatile route to actively control light–matter interactions at the nanoscale. Here, we report all-optical, light-induced domain-selective control of second-harmonic ge...

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2...

Fasting-induced headache in Ramadan: a scoping review with implications for clinical practice

Introduction Headache attributed to fasting is a recognized secondary headache in the International Classification of Headache Disorders, 3rd edition (ICHD-3), defined as a diffuse, non-pulsating headache developing during fasting and relieved after eating. It is especially relev...

Pediatric effects of forever chemicals may last for a long time

Abstract Perfluorinated alkylate substances (PFASs) have been in use for about 75 years. Because of their persistence, concentrations in the environment have increased, and absorbed PFAS will remain in the human body, some compounds for many years. The fetus and the newborn infan...

Drug Permeation Dataset Across Diverse Chemical Space Using PermeaPad and High-Throughput Plate Reader Assays

Abstract Purpose High-throughput permeation assays are essential tools in drug discovery for identifying small molecules with favorable permeability, yet quantifying their transport kinetics across biomimetic membranes often relies on resource-intensive chromatographic methods. H...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Challenges and opportunities in behavioural skills training for physical activity

We argue that interventions that empower individuals to manage their behaviour play an important role in physical activity promotion and maintenance. Specifically, we focus on training physically inactive individuals to use self-enactable behaviour change techniques (SE-BCTs) bas...

Primary school teachers’ experiences of their responsibility for pupils’ mental health and well-being

Young people worldwide are increasingly experiencing mental health problems. The aim of the study was to examine how primary school teachers experience their responsibility for pupils’ well-being and mental health. Interviews were conducted with six qualified primary school teach...