University of Rome Tor Vergata

An Optimization Framework for Automated and Human-Operated Fleet Routing

Abstract This paper presents a mathematical model to determine the optimal routes for a heterogeneous fleet comprising autonomous and human-driven vehicles operating in freight distribution. The model is formulated as a mixed-integer programming problem with multiple objectives:...

High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis

Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...

Growth of small localised perturbations in surface quasi-geostrophic turbulence

The butterfly effect, namely the amplification of an initially localised infinitesimal perturbation, is a fundamental hallmark of chaotic systems. While this phenomenon is well understood in low-dimensional chaotic systems, its implications become more complex in spatially extend...

Differential Associations of Emotion Regulation Strategies and Sexual Attitudes with Sexual Shame: A Generalized Additive Model Analysis

Sexual shame is a complex, self-conscious emotion that can severely disrupt sexual and relational well-being. While emotional experiences and cognitive beliefs heavily influence human sexuality, the specific roles of emotion regulation strategies and sexual attitudes in predictin...

Self-care–based clinical and metabolic profiles among adults with type 2 diabetes: a cross-sectional cluster analysis

Type 2 diabetes mellitus is a heterogeneous condition influenced by clinical, metabolic, and behavioral factors. Traditional approaches to diabetes management often rely on single clinical indicators and may overlook meaningful patterns in patients’ self-care behaviors. This stud...

Two-dimensional shear wave elastography assessment of testicular stiffness in healthy cats

Two-dimensional shear wave elastography (2D-SWE) provides quantitative information on tissue stiffness over a broad field of view, but physiological values for feline testes remain poorly defined. This study aimed to characterize testicular stiffness in clinically healthy cats an...

Melatonin beyond chronobiology: integrating pharmacokinetics, dose-exposure forecasting, and clinical evidence

Abstract Melatonin is established as a regulator of circadian timing and sleep, while a wider range of receptor-dependent and receptor-independent biological effects has generated interest in additional therapeutic applications. This review critically examines whether those propo...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

DARE to wear: digital health promotion and disease prevention using wearable devices

Global healthcare systems are under increasing strain to ensure long-term sustainability, necessitating a transition towards proactive, preventive healthcare strategies. Wearable sensor technologies are uniquely positioned to facilitate this paradigm shift by allowing continuous...

A tropical version of Martens' theorem for metric graphs

Abstract We study the conjecture stated by Jensen and Len on a tropical version on Martens' theorem via the Brill–Noether rank of a tropical curve. We recall Coppens' counterexample of Martens‐special chain of cycles, and we generalize the construction defining another class of g...

Quantum Algorithms for Trading: A Survey of Speedups, Thresholds, and Dequantization

Quantum algorithms for trading span computational tasks with different input models and standards of evidence. This structured critical review describes its search scope, selection criteria and limitations, and distinguishes reported findings from author assessments. Amplitude es...

Activities and Role Perceptions of Clinical Research Nurses in Participating Italian Scientific Research Hospitals: A Multicentre Cross-Sectional Survey

Background/Objective: Clinical research nurses (CRNs) support participant care and trial conduct, yet their role is inconsistently recognised and integrated in Italian Scientific Institutes for Research, Hospitalisation and Healthcare (IRCCSs). This study aimed to describe the pe...

Building families—Implementing balanced sexual and reproductive health

Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

Immune Profiling and Rapid Molecular Diagnostics in Severe Respiratory Infections and Sepsis: The Potential Clinical Perspective of CD169 and CD64

Acute respiratory infections and sepsis remain major causes of morbidity and mortality worldwide. Rapid pathogen identification and characterization of the host immune response are crucial for timely diagnosis and appropriate treatment. CD169 and CD64 have emerged as promising bi...

Environmental Sustainability-Related Knowledge, Behaviors, and Perceived Barriers Among Italian Intensive Care Unit Nurses: A Cross-Sectional Survey

Background/Objectives: Healthcare systems are increasingly recognized as contributors to climate change, and intensive care units represent particularly resource-intensive clinical environments. Nurses play a central role in shaping daily care practices that may influence the env...

Building Families—Implementing Balanced Sexual and Reproductive Health

ABSTRACT One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

Integrating Quantitative and Qualitative Methods in Participatory Environmental Research: Insights from the REGACE Project.

This paper investigated how environmental meaning-making is strongly influenced by participants' cultural backgrounds. However, participatory research often faces challenges in incorporating diverse knowledge systems within technoscientific innovation frameworks. The Horizon 2020...

Integrating Quantitative and Qualitative Methods in Participatory Environmental Research: Insights from the REGACE Project.

This paper investigated how environmental meaning-making is strongly influenced by participants' cultural backgrounds. However, participatory research often faces challenges in incorporating diverse knowledge systems within technoscientific innovation frameworks. The Horizon 2020...

Indications, Techniques and Complications Associated With Pterygoid Implants: A Systematic Review and Meta‐Analysis

BACKGROUND AND OBJECTIVES: Pterygoid implants represent a graftless option for rehabilitation of patients with posterior maxillary atrophy, engaging the dense cortical bone of the pterygomaxillary complex. Despite clinical growth, a comprehensive synthesis of indications, surgica...

Arbovirus co-circulation and epidemiological convergence in a changing climate: challenges for surveillance, diagnosis and public health preparedness

Abstract Arboviral diseases are undergoing substantial epidemiological changes driven by climate change, urbanization, global mobility, vector expansion, and evolving ecological conditions. These processes increasingly favor the geographic overlap and co-circulation of multiple a...