University of Rome Tor Vergata

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Deep Learning for Quantitative Perfusion 99mTc-ECD SPECT in Clinically Confirmed Neuropsychiatric Systemic Lupus Erythematosus: Comparison with Established Software

Abstract Purpose We compared a novel deep learning (DL)-based quantification software (BTXBrain) with an established platform (Q.Brain) for quantitative perfusion single photon emission computed tomography (SPECT) in patients with clinically confirmed neuropsychiatric systemic lu...

Eco-Emotion Profiles Among Parents and Links to Violent and Neglectful Parenting: Parental Burnout as a Mediating Pathway

Climate change is a psychosocial stressor with implications for parenting and child safety. Many parents experience eco-emotions that can tax caregiving resources and self-regulation, yet evidence is scarce on how eco-emotion profiles relate to parental burnout and violent and ne...

KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution

Abstract The tumor suppressor KDM6A / UTX , a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic en...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

Long-term Clinical Outcomes of Autologous Non-activated Platelet-rich Plasma (A-PRP) Delivered Through Mechanical and Controlled Infiltration in Male and Female Androgenetic Alopecia: A 10-year Prospective Randomized Evaluator-blinded Study

BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of progressive hair loss in men and women and is associated with significant psychosocial distress. Platelet-rich plasma (PRP) is a regenerative therapy that stimulates follicular activity, angiogenesis, and dermal...

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Transcriptomic profile and endothelial changes during differentiation syndrome in acute promyelocytic leukemia

Abstract Acute promyelocytic leukemia (APL) is curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), but differentiation syndrome (DS) remains a potentially life-threatening complication, with poorly understood pathogenesis. We investigated clinical, molecular a...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

Introducing a New Research Design: The Multidimensional Interpretative Textual (MIT) Design. Epistemological and Methodological Foundations

ABSTRACT Contemporary nursing research increasingly generates large and complex textual corpora from interviews, open‐ended surveys, clinical documentation, policy discourse and professional narratives. Although these materials contain rich representations of professional reasoni...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Exploring Professional Experiences in Caring for Vulnerable Migrants in an Italian Rural Reception Centre: A Qualitative Study Using Multidimensional Textual Analysis—Professional Experiences in Rural Migrant Care

ABSTRACT Aim This study aims to explore the experiences, strengths, challenges, and potential improvements for professionals in managing the complex needs of vulnerable migrants (VM) in an Italian rural reception centre. Methods A qualitative study using semi‐structured interview...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...

When Stakeholder Pressure Meets Green: Explaining Sustainable Supply Chain Management Adoption in a Late EU ‐Accession Economy

ABSTRACT Recent regulations have introduced unprecedented mandatory sustainability requirements for EU companies, with significant implications for firms embedded in supply chains. These requirements increasingly affect not only large companies but also small and medium‐sized ent...

The Atiyah–Sutcliffe conjecture and En algebras

We show that a certain conjecture by Atiyah and Sutcliffe implies the existence of an E3-algebra (respectively E2-algebra) structure on the disjoint union of all complex (respectively real) full flag manifolds modulo symmetric groups. Moreover, we show that these structures are l...

Collusion through debt and managers

Abstract We investigate the anticompetitive effects of debt financing and managerial incentives in the presence of managers incurring personal bankruptcy costs. We characterize the strategic value for firms' shareholders of resorting to debt and managerial incentives as complemen...

Five Conserved microRNAs Dominate the Small-RNA Pool of Three Arid-Zone Camel-Forage Plants: De Novo Repertoires and a Species-Matched Test of Cross-Kingdom Targeting in the Dromedary

Background: Camel husbandry underpins food security in drylands, and dromedary (Camelus dromedarius) milk is valued as a functional food whose composition is thought to be shaped by the desert forage that camels browse. Dietary plant microRNAs (miRNAs) have been proposed as one m...

Neural integrator and orchestrator communities shape spontaneous signaling in the human brain

Understanding how intrinsic brain dynamics are organized is critical for explaining human cognition and sensory processing. Theoretical frameworks propose a hierarchical architecture in which some neural systems act as orchestrators, broadcasting information across the brain, whe...

Bateman–Horn, polynomial Chowla and the Hasse principle with probability 1

Abstract With probability 1, we assess the average behaviour of various arithmetic functions at the values of degree 𝑑 polynomials f ∈ Z ⁢ [ t ] f\in\mathbb{Z}[t] that are ordered by height. This allows us to establish averaged versions of the Bateman–Horn conjecture, the polynom...

Assessing the Climate and Habitability of Tidally Locked Rocky Exoplanets

Tidally locked exoplanets orbiting M dwarf stars are prime targets in the search for habitable worlds, yet their complex climate dynamics challenge conventional models of habitability. We homogeneously estimated the liquid–water habitability of exoplanets with the highest up-to-d...