University of Rome Tor Vergata

Horizon Scanning of Multiple Sclerosis Expenditure in Italy (2025–2029): Updated Insights from the Oracle Model

Multiple sclerosis (MS) is a chronic and progressively disabling neurological disease associated with a substantial clinical and socioeconomic burden. The introduction of an increasing number of new innovative therapies has further intensified concerns regarding the long-term sus...

Translation, Cultural Adaptation and Psychometric Validation of the Italian Version of the Dignity in Care Scale for Nurses

AIM: To translate, culturally adapt and validate the Dignity in Care Scale for Nurses (DISC-N) into the Italian language. DESIGN: A national multicentre cross-sectional study. METHODS: Translation and cultural adaptation followed recognised guidelines for health measurement instr...

Examples of non-amenable, boundary-amenable dynamical systems

Let \Gamma be a discrete countable group with the (AP)-property. It is shown that if \Gamma acts on a countable set \mathfrak{X} in such a way that the infinite intersection of stabilizer subgroups is always trivial, then the induced action of \Gamma on \partial_{\beta} \mathfrak...

Radiation damage in serial femtosecond crystallography studied in hemoglobin.

) and fixed photon energy (7.15 keV). Structural refinement produced very similar models and resolution-dependent data-quality indicators remained comparable. Both datasets also retained sufficient anomalous signal for phasing. These observations support the conclusion that high-...

Competence, performance evaluation, and educational needs of middle nurse managers in the Italian healthcare system: A qualitative study

Background Existing literature highlights the essential role of middle nurse managers (MNMs) in ensuring communication, coordination, and quality within healthcare organisations, demonstrating the need for deeper insight into their competencies, educational needs, and evaluation...

Unveiling the Molecular Driving Forces of Pollutant Extraction by Hydrophobic Eutectic Solvents

Abstract Hydrophobic eutectic solvents (HES) are emerging as sustainable alternatives to conventional organic solvents for the extraction of molecular pollutants from water. Yet, their selectivity remains poorly understood, hindering the predictive design of eutectic solvents bey...

Effects of dupilumab on nasal mucociliary clearance in severe CRSwNP: evaluation of the saccharin test as an objective outcome measure

OBJECTIVE: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic, relapsing condition associated with a significant impairment in quality of life. Persistent inflammation contributes to dysfunction of mucociliary clearance. Dupilumab (IL-4Rα inhibitor) is a well-establis...

Fast and Efficient Estimation of Macromodels with Large Shocks

We propose a new approach for efficiently estimating and analyzing macroeconomic models subject to large shocks. We apply the methodology to a two-sector model that captures the heterogeneous exposure of different sectors to the COVID-19 pandemic. We solve the model nonlinearly a...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Asymptotic analysis of higher-order perturbations of the Perona–Malik functional

Abstract The Γ-limit of higher-order singular perturbations of the Perona–Malik functional is analyzed. The energies considered combine the critically scaled logarithmic term with a k -th order regularization designed to balance bulk and interfacial effects. A compactness result...

Digital pathways to circular economy adoption: the roles of digital innovation and open innovation

Purpose This study explores the contributions of digital capability, digital orientation and digital transformation towards digital innovation, open innovation and the circular economy adoption. Design/methodology/approach The study's framework is based on a rigorous literature r...

HIV-1 Drug Resistance in Mother–Infant Pairs in Southern Mozambique

This prospective nested cohort (EARTH) study evaluated drug resistance mutations and outcomes among 79 (31 with genetic results) early-treated Mozambican children living with HIV, followed for 50 months. Mortality reached 20.3%. Drug resistance mutations were detected in 58.1% of...

Internalized weight stigma and associated clinical features in treatment-seeking adults with obesity: a multicenter Italian study

Abstract Background This study aimed to evaluate the prevalence and clinical correlates of internalized weight stigma in patients with obesity seeking treatment in various clinical centers across Italy. Methods A total of 438 patients with obesity were included. Patients complete...

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

Beyond Psoriasis Skin Clearance: Effects of Bimekizumab and Tildrakizumab on Systemic Inflammation and Immune-Nutrition Status

Background/Objectives: Psoriasis is a chronic immune-mediated inflammatory disease associated with a high systemic burden. Inhibition of the IL-23/IL-17 axis is the cornerstone of therapy, although the evaluation of immune-nutritional status in the assessment of psoriatic disease...

Pink queue and double standard: new evidence on gender gaps from the Italian academia

Abstract Gender disparities in academic careers remain pronounced, particularly in access to the highest ranks. This paper provides new evidence on these inequalities by modeling academic career progression as a dynamic process. Using a Markov multi-state model, we analyze transi...

Impact of GLP1Ra and SGLT2i on atrial fibrillation in overweight, non-diabetic patients: A meta-analysis of randomized evidence

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1Ra) are breakthrough therapies for type 2 diabetes (T2DM), exhibiting pleiotropic effects. Their clinical use has expanded to lower-risk populations, including overweight and ob...

Long-term outcomes and treatment cost estimates of flavonoids and polidocanol foam sclerotherapy for hemorrhoidal disease: a retrospective cohort study

Abstract Background Flavonoids and sclerotherapy are first-line treatments for hemorrhoidal disease (HD), but direct comparisons of long-term outcomes, patient satisfaction, and economic estimates are limited. Methods This single-center retrospective study included consecutive pa...

High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis

Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...

Neuroinflammation in Neurodegenerative Diseases: A Narrative Update (2020–2026) on Metabolic, Molecular, Morphological, and Functional Imaging

Neuroinflammation is increasingly recognized as a biologically relevant component of neurodegenerative disease, yet its in vivo imaging remains difficult to interpret. This narrative update synthesizes original imaging studies published between January 1, 2020, and May 17, 2026,...