University of Pittsburgh

Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial

OBJECTIVE: Autism spectrum disorder care is often complicated by co-occurring psychiatric symptoms. Equine-assisted services show promise for improving behavioral outcomes in this population. We aimed to examine benefits of equine-assisted services for youth with autism at higher...

AUTOMATING INTERACTION DYNAMICS NOTATION FOR REAL-TIME TEAM ANALYSIS

Abstract Communication plays a central role in how engineering design teams generate ideas, negotiate decisions, and make progress. Interaction Dynamics Notation (IDN) offers a structured way to study these interactions, but its reliance on manual, post hoc coding limits how wide...

The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics

Proteostasis is essential for cellular health, with its disruption contributing to aging, neurodegeneration, and metabolic disorders. While the upstream proteotoxic stress-sensing and protein-folding mechanisms in the ER and cytosol are well studied, the transcriptional regulatio...

Improving Discharge Instructions: Systematic Review of Language and Health Literacy Interventions.

CONTEXT: Effective pediatric inpatient discharge relies on clear, responsive communication to support safe transitions from hospital to home. Families who use a language other than English and those with lower health literacy experience disproportionate barriers during discharge,...

APOE Genotype–specific Cognitive Response to Aerobic Exercise in Postmenopausal Women with Breast Cancer

Cognitive symptoms are common in postmenopausal women treated for breast cancer (BC). In general and in BC, the Apolipoprotein E 4 allele ( APOE4) is linked to lower cognition and accelerated cognitive decline, but exercise generally benefits cognition. The purpose of this study...

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Abstract Background: Pancreatic surveillance commonly detects pancreatic cysts, most of which are presumed intraductal papillary mucinous neoplasms (IPMN). FUT2, the gene responsible for secretor status, has been implicated in IPMN development, although not with pancreatic cancer...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

Innate allorecognition induces HSP70 in monocytes contributing to renal allograft rejection

After encountering allogeneic nonself, monocytes differentiate to DCs, which in turn activate the adaptive immune system that drives transplant rejection. The downstream mechanisms of allorecognition are largely unknown. We analyzed scRNA-seq data sets to identify transcriptional...

Survival and Reoperation After Intralesional Procedures Versus Resection and Reconstruction for Renal Cell Carcinoma Bone Metastases

Background: The management of renal cell carcinoma (RCC) long-bone metastases often involves surgery with either resection and reconstruction (R&R) or intralesional (IL) procedures. Some literature suggests that R&R improves survival and reduces the risk of recurrence and reopera...

Associations Between Physical Activity Measurement Modality and Gut Microbiome in Breast Cancer Survivors

Background/Objectives: Physical activity (PA), physiological fitness, and the gut microbiome have each been linked to health outcomes among breast cancer survivors (BCS); however, these associations have been inconsistent. Few studies have directly compared the associations of se...

Staphylococcus aureus PSMα1 amyloid structure is modulated by buffer and salt

Amyloid fibrils share a characteristic cross-β structure yet often display pronounced polymorphism, where a single protein or peptide sequence can adopt multiple distinct fibrillar architectures. Environmental factors such as buffer composition, ionic strength, and pH strongly in...

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...

A split attractor design for rapidly writing a navigational goal

Recurrent attractor networks are widely thought to form the basis of working memory1–3, but how they can be rapidly switched on and off is unclear4–7. Here we investigate stability and switching in a recurrent circuit of the fly navigation centre8. h∆K and PFG neurons are recurre...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

Compositional Data Analysis of Relative Body Mass and Physical Function Using the Relative Shift Approach

ABSTRACT Objective The purpose of this study was to present the novel relative shift approach for compositional data analysis of body composition as a predictor for gait speed and to compare it to existing methods. Methods Body composition was quantified from dual‐energy x‐ray ab...

STiLE: Automated Tissue Microarray Dearraying for Spatial Transcriptomics

Tissue microarrays (TMAs) enable high-throughput spatial transcriptomic profiling of dozens of tissue cores on a single slide. However, existing dearraying methods operate on histological images and do not support the coordinate-based outputs of spatial transcriptomics platforms....

Central Bank Economic Transparency and Managerial Learning

Abstract Central banks increasingly disclose their private information regarding the economy’s current and future state (CBET). Consistent with CBET shifting investors’ collection and pricing of aggregate-level (where managers do not have an information advantage) toward firm-lev...

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction

Urothelial ATP release during bladder filling modulates afferent nerve activity and detrusor contractility to regulate the micturition reflex, yet the upstream mechanosensory mechanism linking distension to ATP release remains unclear. Here we investigated the role of Piezo1 in r...