Institution
University of Pittsburgh
Recent research
- Health & Medicine
Mean arterial pressure for children in US emergency department and prehospital settings
Objectives To externally validate previously reported centile curves for the mean arterial pressure (MAP) on paediatric acute care samples; derive centile curves for paediatric MAP in an acute care population and evaluate the association of age-adjusted MAP with prehospital and i...
- Health & MedicineOpen access
Abstract Aim Physical activity (PA) positively impacts health, but the optimal way to achieve PA remains unclear. Pure and total movement dispersion are novel metrics that quantify the spread of movement across the day, with (total) or without (pure) intensity. The purpose of thi...
- Health & MedicineOpen access
PURPOSE/OBJECTIVE: Psychological appraisal processes of pain catastrophizing (PC) and perceived injustice (PI) are involved in the transition to postinjury disability. Although these factors are modifiable and may serve as ideal intervention targets to improve recovery, they have...
- Health & MedicineOpen access
ABSTRACT Background Ultrashort echo time T2* (UTE‐T2*) mapping is sensitive to the composition of deep cartilage and menisci. UTE‐T2* elevations are common after anterior cruciate ligament (ACL) injuries, but their long‐term prognostic importance is unknown. Hypothesis Higher pre...
- Materials & Energy
Catalytic Redox-Neutral Decarboxylative Aromatization via Transfer Dehydrogenation
Abstract Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization sometimes struggle to achieve diverse substitution...
- Materials & Energy
Annealing SrTiO3 produces an iron-rich surface layer
SrTiO3 (STO) is among the most widely used substrates in complex oxide heterostructure research, yet the role of its trace impurity content in determining interface properties remains poorly understood. Here, we show that high-temperature annealing (the standard procedure for pre...
ABSTRACT Organoboron compounds are versatile building blocks for C─C and C–heteroatom bond formation, with broad applications in drug discovery and materials science. Hydroboration of alkenes with hydroboranes is a reliable route to access organoboron compoundsssssss, yet the Mar...
- Open access
Abstract Nanoparticle (NP)-based drug delivery has been explored to improve the therapeutic index of anticancer agents by enhancing tumor accumulation and reducing systemic toxicity. Among active targeting approaches, cluster of differentiation 44 (CD44) has attracted attention b...
- Society & EconomicsOpen access
Although academic libraries increasingly use exhibitions to support education, cultural engagement, and community outreach, less is known about how staff experience this work and the organizational conditions that shape their participation. This qualitative study examines cultura...
- Health & MedicineOpen access
Despite substantial treatment improvements, the 5-year survival rate for metastatic osteosarcoma (OS) is still as low as 20%. Immunocompetent genetic mouse models of OS have been introduced, enabling in vivo OS studies. Here, we present the ROCCIA mouse, a quintuple-mutant extens...
- Health & Medicine
Background & Aims: Hepatocellular carcinoma (HCC) remains among the most lethal cancers worldwide, yet few tools exist to characterize HCC biology and stratify patient risk at the point of care. We developed TESERA (Tissue Encoded Subtype Elucidation and Risk Assessment), a compu...
- Health & Medicine
BACKGROUND: We aimed to estimate contraceptive claims prevalence among reproductive-aged women with selected autoimmune diseases compared with those without these conditions in 2019. MATERIALS AND METHODS: Using IBM MarketScan Commercial Claims and Encounters and Multistate Medic...
- Health & MedicineOpen access
BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...
- BiologyOpen access
Intrinsic Tension Drives Palatal Shelf Reorientation post Tongue Retraction
Cleft palate can be caused by failure of elevation of the palatal shelves over the tongue during development. The physical mechanism of elevation is poorly understood. It is thought that elevation is obstructed by the tongue in a condition known as Pierre Robin sequence (PRS), in...
- Physics & SpaceOpen access
JWST Nebular Spectroscopy of SN 2023qov: Circumstellar Dust Emission in a Normal Type Ia Supernova
Abstract We present panchromatic observations of the Type Ia supernova (SN Ia) 2023qov, ranging from ∼2 weeks before to ∼1 yr after maximum light. JWST near- and mid-infrared spectra at +276 and +363 days show ∼400 K dust emission that cools by ∼75 K between epochs, the first una...
- BiologyOpen access
Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...
- Health & MedicineOpen access
On the Inhibition of Lipid Peroxidation and Ferroptosis by Fatty Acids
Most inhibitors of lipid peroxidation (LPO) and associated ferroptosis are small molecules that trap LPO-propagating radicals. Among the handful of other inhibitors are select fatty acids: monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids substituted with deuter...
- BiologyOpen access
Desulfinylation of the deubiquitinase USP7 by SRXN1 attenuates oxidative acute liver injury
Protein S -sulfinylation is a reversible oxidative cysteine modification, but its contribution to acute liver injury such as those induced by acetaminophen (APAP) overdose has not been reported. Sulfiredoxin-1 (SRXN1) is the only oxidoreductase known to reduce the sulfinylated pr...
- Climate & EnvironmentOpen access
ABSTRACT We report the complete genome sequences of the Arthrobacter globiformis B-2979 phages Crescenzo, Roberts, and Gerri43. Crescenzo contains unique genes without recognizable homologs, while Roberts and Gerri43 lack a ribonucleotide reductase gene. Roberts genes 52 and 61 l...
- Health & Medicine
Urinary tract infection (UTI) is one of the most common bacterial infections in infants and young children, with a prevalence of 7% in infants with fever. This clinical practice guideline (CPG) provides an update of the literature and clinical recommendations of the 2011 American...