University of Nottingham

Both CD8+ and CD4+ T regulatory cells are associated with poor survival in colorectal cancer

Abstract Previous studies in colorectal cancer have linked high levels of FoxP3 + regulatory T-cells (Treg) (CRC) to favourable prognosis. However, this contradicts the well-established immunosuppressive function of Treg. We resolved this conundrum using multiplex immunohistochem...

Practitioner psychologists’ experiences of delivering a cognitive behavioural therapy informed crisis intervention for psychosis in inpatient settings: a mixed methods investigation within the CRISIS study

Abstract Objectives Cognitive behaviour therapy for psychosis (CBTp) should be delivered in psychiatric inpatient settings, yet little is known about therapists’ perspectives on delivering it. This study examined therapists’ perspectives on delivering a crisis-focused CBTp-inform...

Maximizing stem body size may reduce the risk of postoperative periprosthetic fractures

Aims: There is concern around an increased risk of postoperative periprosthetic fracture (POPPF) with cemented polished taper slip (PTS) femoral components. We hypothesized that femoral constructs resulting in increased load on the cement mantle would be associated with higher PO...

Globalization and Market Power

ABSTRACT We use a large episode of trade liberalization in Spain to test a rich set of channels linking trade and markups. The effect of reductions in import tariffs on firm‐level and aggregate markups is pro‐competitive, but there are offsetting effects via other channels. We sh...

Air quality assessment in the context of landfill mining activities

Landfill mining (LFM) is a strategy aimed at mitigating any remaining potential adverse environmental impact of landfill sites whilst also recovering untapped commodities and energy for utilisation, as well as freeing up land resources for beneficial use. Many studies have highli...

EmotionaL and Language Recovery in Aphasia (ELLA): Codesigning and Proof-of-Concept Testing a Novel Intervention

Purpose: People with aphasia are at risk of becoming depressed, anxious, and isolated. They want therapy to focus on improving communication, confidence, and finding ways to live well; family members want to be involved in the therapy process. We aimed to codesign and test a nove...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Order amidst chaos: recognising patterns in the geography of out of area housing

One aspect of the UK housing crisis is the high number of households living in temporary accommodation. This paper looks at temporary accommodation households placed ‘out of area’ into other local authority areas. Whilst this may appear to be a chaotic picture of households being...

Quantifying the Equine Pain Response to Paracetamol Administration in Horses With Chronic Lameness Already Receiving Non‐Steroidal Anti‐Inflammatories

ABSTRACT Paracetamol is used in horses alongside non‐steroidal anti‐inflammatories (NSAIDs) for multi‐modal analgesia; however to date there are few studies published which have investigated its analgesic effect in the horse. Horses were recruited to this study from a population...

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation

Insulin resistance (IR) has emerged as a risk factor for lactation insufficiency and delays the onset of milk secretion after childbirth, termed secretory activation (SA). This may cause inadequate infant weight gain and early breastfeeding cessation. However, the mechanisms unde...

Assessing iron, zinc and calcium bioaccessibility using the INFOGEST method: Challenges and opportunities

Abstract Iron, zinc and calcium are essential minerals required for key physiological functions, including oxygen transport, immune function, enzymatic activity and bone health. Despite their importance, deficiencies remain widespread globally, driven in part by the poor bioavail...

Aphasia treatment research: a decision-making tool to guide the design of phased trials from the Collaboration of Aphasia Trialists (CATs) trials for aphasia panel

Background Systematic reviews of randomised controlled trials with meta-analyses indicate that speech and language therapy for aphasia after stroke is effective in improving communication. However, high-quality evidence to identify an intervention’s target population (who), regim...

In children requiring emergency vascular access, are intraosseous lines associated with significant long-term complications?

Intraosseous (IO) access is a technique increasingly used within trauma and emergency settings where immediate vascular access is required. It provides an effective alternative to intravenous access, particularly in paediatric patients where intravenous access is difficult, or wh...

Comparing experience intensity of AR and VR for contrasting phobia stimuli

Abstract Exposure-based therapy is a common psychological intervention for phobias and anxiety disorders, and exposure-based therapy using virtual reality (VR) and augmented reality (AR) have been evaluated as practical extensions of this method, producing similar experiences thr...

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circu...

Swallowing therapy for dysphagia in acute and subacute stroke

RATIONALE: Post-stroke dysphagia ((PSD) impaired swallowing following stroke), increases risk of death, yet the effects of potential treatments are unclear. This review updates the 2018 review. OBJECTIVES: To assess the effects of swallowing therapies on swallowing impairment (SI...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

Prospects of green iron- and steelmaking via the FFC Cambridge process

The FFC Cambridge Process promises green iron-/steelmaking, where the respective metal oxides are used as the cathode in a molten electrolyte. Laboratory tests have validated the process at 500–900°C in molten chlorides, carbonates, fluorides or hydroxides. The reduction proceeds...

Midproject Peer Assessment Effect on Group Dynamics and Transferable Skills

Abstract Peer assessment has been widely used in educational settings, particularly in group projects. Despite its known benefits, there is limited evidence on how the design of peer assessment activities influences group dynamics or how it can be used as a mechanism to foster th...