University of Maryland, Baltimore

Cirrhosis severity modulates proteomic and immune landscapes in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) most often arises in cirrhotic livers, yet the biological impact of cirrhosis severity on the tumor proteome remains poorly understood. Here, we performed a comprehensive quantitative proteomic analysis of 141 HCC tumors stratified by the d...

Combinatorial action of regulatory systems generates colistin heteroresistance

ABSTRACT Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresistance is common among Enterobacter cloacae clinical isolates, threatens its utility as a last-line t...

Adductor-Related Athletic Groin Pain: A Clinical Commentary

Adductor-related athletic groin pain (ARAGP) is a common condition in athletes participating in multidirectional, high-intensity sports. It is challenging to diagnose and manage due to complex regional anatomy and overlapping clinical presentations. ARAGP represents the most freq...

Effect of a Machine Learning Algorithm to Guide Goal-Directed Therapy After Cardiac Surgery

Background Goal-directed therapy allows clinicians to optimize perfusion and volume status in patients postoperatively. Objective To evaluate the effect of a machine learning algorithm to guide postoperative goal-directed fluid therapy in cardiac surgery patients. Methods A goal-...

SOX2 and cytokeratins 5, 8 and 18 as potential stem cell biomarkers in botryoid odontogenic, lateral periodontal and gingival cysts.

The aim of this study was to compare the immunohistochemical expression of SOX2 and cytokeratins (CKs) 5, 8 and 18 in the lateral periodontal cyst (LPC) and gingival cyst of the adult (GCA) with the more aggressive botryoid odontogenic cyst (BOC), to evaluate diagnostic or progno...

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation

Oncogenic KRAS and NRAS mutations are common in hematologic malignancies, but how they signal is less well characterized than in carcinomas. To uncover novel RAS biology and potential therapeutic vulnerabilities, we employed a multi-omics screening approach in multiple myeloma to...

The Björck classification of the open abdomen revisited: clarifying concepts for modern complex abdomen management

Abstract Introduction The open abdomen (OA) has become an integral component of modern acute care, trauma, and vascular surgery. Since 2009, the Björck classification, amended in 2016, has provided a common language for describing the status and progression of the OA and remains...

AI in the Exam Room: Its Potential to Transform the Healing Relationship in Rheumatology and Beyond

Data S1: Disclosureform Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Schizophrenia: advances in pathophysiology, management, and precision medicine

Abstract Schizophrenia is a common and severe mental condition with onset usually in late adolescence and young adulthood. Schizophrenia is caused by a combination of multiple genetic and environmental factors with significant neurodevelopmental implications. Advances in the clin...

Secretagogin immunoreactivity in the forebrain, midbrain and pituitary of the three spot gourami, Trichopodus trichopterus (Pallas, 1770)

Abstract Secretagogin (SCGN), a calcium‐binding protein (CBP) implicated in neuroendocrine signaling, was investigated for its spatial distribution in the forebrain, midbrain, and pituitary of the three spot gourami, Trichopodus trichopterus, a representative labyrinthine teleost...

Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color

Purpose: To examine structural, informational, and cultural barriers to clinical trial participation among women of color (WOC), with emphasis on adolescents and young adults (AYAs), through a community-partnered study to illuminate persistent challenges and generate actionable s...

HMGB1-targeted anti-inflammatory rBox A gene therapy for viral airway infections and systemic inflammatory disease models

High mobility group box 1 (HMGB1) is a host-derived proinflammatory molecule released during cell injury. Elevated extracellular HMGB1 levels have been associated with disease severity. HMGB1 contributes to host influenza responses by stimulating TLR4/MD-2 signaling, amplifying l...

Divergent complication patterns of type 2 diabetes in African individuals who are lean versus overweight or obese: a multi-cohort analysis

Abstract Aims/hypothesis Nearly 40% of African adults with type 2 diabetes are lean (BMI <25 kg/m 2 ). Emerging evidence suggests that type 2 diabetes in African individuals who are lean may represent a distinct phenotype driven by impaired insulin secretion rather than insulin r...

“My heart is at peace because I know that I am protected:” understanding the factors that facilitate adolescent girls and young women’s uptake of long-acting injectable PrEP in Zambia

Adolescent girls and young women (AGYW) in EASTERN AND SOUTHERN Africa face a disproportionate risk of HIV acquisition. While effective, uptake of daily oral pre-exposure prophylaxis (PrEP) for HIV prevention among this population has remained inadequate. Hypothetical preference...

Contemporary Treatment Patterns in Surgically Treated Temporal Bone Cancer

OBJECTIVES: To characterize the sociodemographic features of patients with temporal bone carcinoma and evaluate current treatment patterns. METHODS: This study analyzed data from the Cosmos database (2015-2024) to identify patients with surgically treated temporal bone malignanci...

Moving From Laboratory to Clinical Metrics for Diagnostic Tests

This Viewpoint explores the distinction between analytical and diagnostic performance measures.

Fertility in the Shadow of Cancer: Experiences of Reproductive Loss Among Women with Gynecological Cancers in Ghana

Abstract Background Gynecological cancers and their treatments can compromise fertility, with profound psychosocial consequences for women of reproductive age. Yet, women’s lived experiences of cancer-related infertility remain underexplored in low-resource settings, including Gh...

From Policy to Practice: A Statewide Model to Expand School-Community Mental Health Partnerships

Abstract Schools are a primary access point for youth mental health services, yet most lack the sustained funding, infrastructure, and partnerships needed to build comprehensive and equitable systems of care. State policy offers a mechanism to address these limitations, but there...

Acceptability and Feasibility of a Primary Care Hypoglycemia Prevention Program: A Pilot Study

OBJECTIVE Hypoglycemia, a major cause of morbidity for people with diabetes, is underrecognized in primary care, leading to underuse of risk mitigation strategies. This study reports the development and acceptability/feasibility testing of the Hypoglycemia Prevention Program (HPP...

Community-Led Operationalization of a Champion Implementation Strategy for Anal Cancer Prevention in Nigeria

Abstract Context-specific adaptation of implementation strategies is an important component of promoting evidence-based intervention use. But guidance on systematic approaches is limited. Here we described our mixed method approach to adapting (Study 1) and monitoring (Study 2) a...