University of Maryland, Baltimore

A modified Delphi study of expert consensus on mental health service access and digital strategies for adolescents and young people living with HIV in Zambia

Adolescents and young people living with human immunodeficiency virus (HIV), hereafter AYPLHIV, experience depression, anxiety, behavioural difficulties, and psychosocial distress that may undermine antiretroviral therapy (ART) adherence and long-term HIV outcomes. In Zambia, men...

Synergistic effects of cerebrovascular reactivity and gray matter volume on executive function in aging

Background Age-related impairments in cerebrovascular reactivity (CVR) and gray matter volume (GMV) both contribute to cognitive decline, yet their regional interplay and joint impact on cognition remain unclear. Objective To investigate how CVR and GMV are coupled and interact r...

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

Cryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase

Abstract ZNFX1 is an RNA helicase that plays a critical role in host defense against viral infections. Recent studies further revealed that ZNFX1 harbors an unexpected RNA-ubiquitinating E3 ligase activity, raising fundamental questions about how RNA-binding activates this multif...

Telemedicine-based buprenorphine initiation and maintenance in rural jails: a retrospective observational study

The persistent U.S. opioid overdose epidemic disproportionately affects incarcerated populations, who face a severely heightened risk of fatal overdose after release. Providing medications for opioid use disorder (MOUD) in jails significantly reduces post-release death and boosts...

MuscleExpert: a semi-automated tool delivering ImageJ-comparable measurements of muscle thickness, area, and quality

Background Most image-analysis software programs were not designed specifically for ultrasound-based measurements, resulting in irrelevant general-purpose features that force users to navigate through multiple menus and making the analysis time-consuming and increasing the likeli...

Synergistic Ni−Fe Nanoalloy Catalysis for CO2-Assisted Tar Reforming: Towards Sustainable Syngas Production via Toluene as a Model Compound

Abstract Efficient conversion of biomass tar, together with effective fixation and valorization of carbon dioxide (CO2), remains a major challenge in renewable energy. Addressing this challenge requires a fundamental understanding of the atomic-scale mechanisms governing CO2-assi...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Hv1 deficiency disrupts splenic antibacterial defense and immune homeostasis 18 months after traumatic brain injury in male mice

Traumatic brain injury (TBI) is increasingly recognized as a chronic condition with lasting systemic consequences. Beyond persistent neuroinflammation, long-term TBI disrupts peripheral immune homeostasis, increasing susceptibility to infection and organ dysfunction, particularly...

RNF5 Regulates HERP1 and OS9 Stability and Modulates Processing of an ERAD Substrate

Endoplasmic reticulum-associated degradation (ERAD) must dynamically adapt to cellular protein-folding demands, yet mechanisms regulating ERAD-associated adaptors remain incompletely defined. Here, we identify the E3 ubiquitin ligase RNF5 as a regulator of the ERAD adaptors HERPU...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

Infant and Toddler Feeding and Development: Habits for a Lifetime

This Special Issue of Nutrients on Infant and Toddler Feeding and Development features feeding as a key element in young children’s early development [...]

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness.

= 76). These participants were tested in working memory and episodic memory paradigms. We applied a computational model that yielded parameters corresponding to memory storage capacity, memory precision, and the rate of attention lapses. We also examined a noncomputational metric...

A qualitative investigation of tobacco use and cessation experiences among people living with HIV in Botswana

Abstract Background Tobacco use is a leading cause of premature mortality among people living with HIV (PLWH), especially in Botswana, where high smoking rates coincide with successful HIV control. There is a need for evidence-based interventions to support smoking cessation amon...

Anxiety and mood disorders are associated with greater healthcare and procedural utilization in idiopathic intracranial hypertension

Background and purpose Anxiety and mood disorders (AMD) are common in idiopathic intracranial hypertension (IIH), but their association with procedural treatment and healthcare utilization is unclear. We evaluated utilization among patients with AMD documented before or shortly a...

“The Rio Grande Was Originally Known as Rio Bravo”: Multiliteracies in a 4th‐Grade ELA and Social Studies Project

ABSTRACT Despite the natural interdisciplinary nature of English language arts (ELA) and social studies, these two subject areas are sometimes isolated from one another in schools, including upper elementary classrooms. In this research‐in‐action article, we—two university resear...

Complete genome sequence of a multidrug-resistant Proteus mirabilis clinical isolate harboring 22 antimicrobial resistance genes including bla CTX-M-15

ABSTRACT Proteus mirabilis causes urinary tract infections and wound infections and frequently exhibits multidrug resistance, complicating patient treatment. Here, we describe the complete genome sequence of a multidrug-resistant P. mirabilis wound isolate from 2025, providing in...

Expanding the Utility of Colistin Adjuvants To Encompass Next-Generation Polymyxins against Polymyxin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Abstract Current treatment options for multidrug-resistant (MDR) Gram-negative infections are effectively limited to last-resort antibiotics, such as the polymyxins. Clinical use of polymyxins remains limited due to significant nephrotoxic side effects, and is further limited as...

S2-Alar-Iliac Pelvic Fixation With Standard vs Porous Fusion/Fixation Implants: An Inverse Probability Weighted 1-Year Preliminary Comparative Analysis

Background Recently, porous fusion/fixation implants (PFFIs) with a 3D-printed porous, fenestrated, bone self-harvesting design were developed for S2-alar-iliac (S2AI) spinopelvic fixation. Prior studies have demonstrated the safety and feasibility of using PFFI for S2AI spinopel...

Angiopoietin-Like 4 Induces Upregulation of VEGF and sVCAM1 Through JNK/c-Jun and JAK2/STAT5 Signaling Pathways

Purpose: Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating angiogenesis, vascular permeability, and inflammation that is elevated, along with vascular endothelial growth factor (VEGF), in multiple ocular neovascular disorders, including ischemic retin...