University of Maryland, Baltimore

Expanding the Utility of Colistin Adjuvants To Encompass Next-Generation Polymyxins against Polymyxin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Abstract Current treatment options for multidrug-resistant (MDR) Gram-negative infections are effectively limited to last-resort antibiotics, such as the polymyxins. Clinical use of polymyxins remains limited due to significant nephrotoxic side effects, and is further limited as...

XID+PRIMA, II: Stepping Through Hyperspectral Imaging to Deblend PRIMAger Beyond the Extragalactic Confusion Limit

The PRobe far-Infrared Mission for Astrophysics concept aims to map large areas with spectral coverage and sensitivities inaccessible to previous FIR space telescopes, covering 25-235um. We synthesise images representing a deep imaging survey, with realistic instrumental and conf...

Uncovering pan-cancer signatures of chemoresistance

Abstract Background Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types. Metho...

Multiplex K-Edge Nanoprobe Imaging Enables 3D Volumetric Molecular Phenotyping of Human Hematoma Membranes

Abstract Spectral photon-counting computed tomography (SPCCT) enables material-resolved imaging through K-edge discrimination, yet its application to multiplexed molecular mapping of human surgical specimens remains underexplored. Here, we report a clinically relevant multiplex K...

Electrochemical Phase Engineering of Li–Ti–P–O Nanocomposite Thin Films

Abstract Nanoscale materials processing advancements have enabled on-chip ionic devices like microbatteries, super capacitors, ion-gated transistors, etc. using standard semiconductor processes (such as atomic layer deposition — ALD) to develop electrochemically active thin films...

Lived experience leadership in cancer research: a scoping review of conceptual definitions, roles, responsibilities, and impacts

Abstract Background The meaningful integration of lived experience expertise into cancer research is increasingly recognized as essential to improving research relevance, quality, and impact. However, the extent to which people with lived experience of cancer hold leadership role...

Rapid Eco-AI CE–MS Enables Sub-7 Min Low-Input Proteome Profiling with Quantitative Validation

Abstract Low-input and single-cell proteomics by mass spectrometry (MS) have advanced rapidly, but balancing analytical speed and sensitivity remains challenging, especially for small, protein-scarce primary cells such as neutrophils. Here, we report Rapid Eco–AI, an optimized el...

Exploring the Possibility of Extrinsic Anion Vacancies in Li6PS5Cl

Abstract The search for superionic conductors requires a deep understanding of the underlying crystal structure and local dynamic processes. Therefore, cationic and anionic substitutions are typically performed to monitor the resulting changes in the structure and ionic transport...

Early-Enrichment Hit Discovery via Reversible-Work c(t) Estimation in Metadynamics (CTMD)

Abstract Virtual screening for small-molecule binders is often limited by false positives from approximate scoring functions and rigid-receptor assumptions. These can be addressed downstream through accurate but expensive free-energy calculations. At the same time, recent artific...

Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling

Piezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. In this study, we showed that Piezo1 and Pi...

Flourishing Childhood Frameworks: A Scoping Review

OBJECTIVES: Experiences in early life impact childhood, lifelong flourishing, and overall well-being. Yet a framework to guide promoting and measuring flourishing in early childhood has not emerged. The objective of this study was to identify frameworks and measures related to pr...

Hospital-Based Severe Maternal Morbidity Surveillance and Review

Background: Learning from promising maternal health interventions is limited by the lack of standardized outcome measures needed for their evaluation. We describe the development and utilization of Maryland’s severe maternal morbidity (SMM) surveillance by the Maryland Maternal H...

Fracture-Controlled Mechanical Behavior of Steel Fiber-Reinforced Ultra-High-Performance Concrete Incorporating Slag and Limestone Powder Under Static and Impact Loading

Ultra-high-performance concrete (UHPC) is characterized by exceptional compressive strength; however, its structural performance is primarily governed by tensile behavior, fracture resistance, and energy dissipation. This study presents a comprehensive mechanical characterization...

RUNX2 inhibitor CADD522 improves bone microarchitecture and lipid metabolism in post-menopausal bone loss

Osteoporosis is a leading cause of age-related morbidity, yet existing antiresorptive and anabolic therapies remain limited by safety concerns, contraindications and poor long-term adherence. CADD522 is a small molecule inhibitor of the RUNX2 transcription factor currently under...

The genomic origins and evolutionary path to a key innovation in the world’s most venomous snakes

Abstract Evolutionary innovation is a key driver of the colonization of new environments and the adaptive radiations of major groups. Novel traits typically evolve through the modification of pre-existing characters but the genetic paths underlying their origin have been challeng...

Development and Assessment of Poly(ethylene glycol) Diacrylate-Embedded Metalloporphyrin for Phosphorescence Lifetime-Based In Vivo Monitoring of Oxygen Tension

Abstract The timely detection of ischemia is crucial for enhancing outcomes in reconstructive surgery. This study presents the development and in vivo evaluation of a metalloporphyrin-based phosphorescence lifetime oxygen sensor embedded in poly(ethylene glycol) diacrylate (PEGDA...

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Abstract Background Traumatic brain injury (TBI) causes long‐term disability, with inflammation contributing to both primary and secondary brain damage. Extracellular adenosine triphosphate (ATP) and its receptor purinergic receptor X7 (P2X7) drive neuroinflammation and represent...

Importance of Single Global Regulatory Standards for the Assessment of Generic and Biosimilar Medicines to Advance Patient Access

Generic and biosimilar medicines are foundational to sustainable healthcare, enabling broader patient access globally through high-quality, cost-effective alternatives. However, their market access is hindered by regulatory fragmentation across major authorities, where regulatory...

Workforce development experiences among older youth and young adults with foster care experience: A qualitative interpretive meta-synthesis

Approximately 19,000 young people age out of foster care annually without achieving permanency in the United States. Young people with foster care experience face disproportionately high rates of unemployment and underemployment, creating barriers to achieving self-sufficiency. U...

Extended Antibiotic Prophylaxis Is Not Associated with Improved Outcomes after Traumatic Neck Aerodigestive Repair

Background: Extended post antibiotics do not reduce infectious complications after traumatic facial injuries or elective clean-contaminated head and neck operation. However, the optimal duration of antibiotic prophylaxis following operative repair of traumatic neck aerodigestive...