University of Lausanne

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

From digital to physical model: testing of a workflow for case-specific 3D-printed bone simulants

Bone simulants are used for a variety of purposes in wound ballistic experimentation. Synthetic simulants have several advantages over biological (either human or animal) material. Generic synthetic simulants are available, but the shapes and sizes of these materials cannot cover...

Microbial inoculants for soil restoration: A Risk-Proportional Stewardship Framework Integrating Strain-Resolved Genomics and Adaptive Governance

Abstract Global soil degradation and increasing reliance on chemical inputs threaten agricultural sustainability, driving interest in microbial inoculants as tools for soil restoration. These biological products have the potential to enhance nutrient cycling, improve soil structu...

Revisiting microplastic pollution: A novel method for detecting small-sized microplastics in natural waters

Abstract Microplastics are widespread, yet methods to measure polymer type simultaneously and particles size smaller than 20 µm are limited, hindering toxicity assessment and policy formulations. We introduce a machine learning-assisted spectral flow cytometry approach that ident...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...

Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents

Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both the potential and the limitations of this strategy. First-generation polymeric st...

X Marks the Spot: Continuities of Colonial Spatial Exploitation in Luanshya, Zambia

ABSTRACT This essay illustrates how a golf course serves as a site for continuities of colonial spatial exploitation in Luanshya, Zambia. It draws on the narratives of alleged abuse of public office by a Zambian member of parliament as reported in media publications between 2012...

From thunder to silence: Cochlear implantation for bilateral profound sensorineural hearing loss after lightning strike

INTRODUCTION: Lightning strikes can cause diverse neuro-otologic injuries. Tympanic membrane rupture is common, whereas bilateral profound sensorineural hearing loss with vestibular dysfunction and perilymphatic fistula is rare. Cochlear implantation for lightning-induced deafnes...

A historical journey through total knee arthroplasty: the evolutionary milestones

PURPOSE: This study aims to examine historical progressions to demonstrate how current debates in alignment philosophy, implant personalization, robotic surgery, and ligament management serve as direct extensions of past concepts. METHODS: The history of TKA was divided into four...

Association of body mass index categories with healthcare use and health expenditures in Switzerland: a cross-sectional, community-based study

BACKGROUND: Increased body mass index (BMI) is associated with increased medical costs, but no information is available for Switzerland. We investigated the association of individual BMI categories with healthcare use and healthcare expenditures. METHODS: Data from an ongoing pro...

Solving problems increases provisioning efficiency, enhancing reproductive success in male great tits

Abstract The ecological and selective processes acting on cognitive traits have received recent attention because of the potentially key role of cognition in rapid behavioural adjustments in response to environmental variation. Innovation, a cognitive process involved in the deve...

Global trade-offs between consumption, carbon prices and equity

As the remaining carbon budget continues to dwindle, economic growth strains efforts to limit global warming to 1.5 °C. Reducing unnecessary production and consumption in high-income regions and among the wealthy, and organising production more around human needs and human well-b...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Intraoperative and postoperative management in endoscopic ear surgery: Perspectives from a worldwide survey

PURPOSE: To examine intraoperative and postoperative practices (antibiotic and antithrombotic prophylaxis, ear packing, behavioural recommendations, follow-up strategies) in exclusive endoscopic ear surgery management, based on a global survey of experienced surgeons. METHODS: Th...

Applicability of Gassmann’s equations to cracked media

Abstract Gassmann’s equations are a cornerstone of rock physics, widely used for fluid substitution modeling and reservoir characterization. However, recent studies have raised concerns about their applicability to cracked media. To address this issue, we carried out a 3D numeric...

Autoantibody Clusters and SIGLEC1 are Predictive of Systemic Lupus Erythematosus Development

Objectives Up to one-third of patients with suspected SLE progress to definite disease, but reliable predictive markers are lacking. Previously, we developed a Lupus Lymphocyte Activation Score (LLAS) based on key cell subsets (transitional B cells, age-associated B cells, plasma...

A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials

Clozapine was (1) first introduced in Austria and Switzerland in 1972, (2) associated with 8 Finnish deaths due to agranulocytosis in 1975 (almost leading to its withdrawal), and (3) approved in the United States (US) for treatment-resistant schizophrenia in 1989 (resulting in a...