University of Illinois Chicago

Anthracycline and antimetabolite, trigger distinct resistance mechanisms in TP53mut AML

Acute myeloid leukemia (AML) is a highly heterogeneous and extremely aggressive form of blood cancer. Despite recent advances, AML continues to be a challenging disease to treat; the overall prognosis and response to therapy are strongly influenced by karyotypic and molecular alt...

Electronic Communication Between Ferroelectric Surface Dipoles and Catalytic Active Sites Under Diverse Reaction Conditions

Abstract Dynamic modulation of the electronic environment of catalytic active sites offers a promising route to overcome the limitations of static catalyst design. One possible direction to achieve this goal is to induce catalyst dynamics via rapid inversion of the surface dipole...

Early Macular Leakage Resolution Is Associated with Extended Faricimab Dosing in Retinal Vein Occlusion: A BALATON/COMINO Post Hoc Analysis

Macular leakage (ML) is a biomarker of disease activity and, in retinal vein occlusion (RVO), is associated with poor vision outcomes. Faricimab, a dual angiopoietin-2 (Ang-2)/vascular endothelial growth factor (VEGF)-A inhibitor, has demonstrated efficacy and durability in RVO....

Dry Eye Disease Therapies at a Crossroads—A Call for Reform

This Viewpoint discusses current approval pathways for dry eye disease medications and the need to advance the standard of evidence for these medications.

The psychosocial impact of neurofibromatosis type 1: a narrative review

Abstract Neurofibromatosis type 1 (NF1) is a rare autosomal dominant (AD) genodermatosis characterized by café-au-lait macules (CALMs), cutaneous and plexiform neurofibromas, and cognitive impairments and neurodevelopmental disorders. As a rare genetic skin disease (RGSD), NF1 is...

Clinically integrated breastfeeding peer counseling to promote breastfeeding equity: Research protocol for patient-centered costs of infant feeding and lactation care

Despite national and international recommendations for exclusive breastfeeding to 6 months of age, 44% of infants receive no breastmilk at this important milestone, imposing a significant cost on the US economy vis a vis elevated cardiovascular, infectious, and metabolic disease...

Examining Trust Among Veterans from Camp Lejeune Exposed to Environmental Toxicants: A Qualitative Study

Abstract Background Serving Veterans with military environmental exposures is a top priority of the Veterans Health Administration (VHA). This priority is critical for over 1 million Veterans and civilians who were exposed to contaminated drinking water at United States Marine Co...

Determinants of Phase-Separation Propensities, Material States, and Material Properties of Biomolecular Condensates

Conspectus Phase separation of various materials has been studied for one and a half centuries, laying foundational principles in materials science. In the last two decades, phase separation of proteins and nucleic acids has received enormous attention, due to its relevance to ce...

Originality in art and other artifacts: an etiological-ecological approach

Abstract This paper proposes an account of artifact function that applies equally to artworks, everyday artifacts, and highly specialized technical artifacts. This unified account of artifact function centers on the notion of proper function and combines reproduction history (eti...

Impacts of neighborhood labels on housing demand

Abstract We examine the salience of neighborhood labels on housing demand using the unanticipated removal of a field that defines geographic area boundaries in the Multiple Listing Service (MLS) property search platform as a natural experiment. These labels plausibly reflect hist...

Hydrogel-based nerve conduit systems with integrated therapeutic cargo and controlled delivery strategies for peripheral nerve regeneration: a systematic preclinical review

Peripheral nerve injuries (PNIs) with nerve gaps remain a major clinical challenge. Although autologous nerve grafting is considered the gold standard for repair, its use is limited by donor-site morbidity and limited graft availability. Recent advances in tissue engineering have...

Outcomes after anterior cruciate ligament reconstruction with versus without lateral extra‐articular tenodesis: A propensity‐matched cohort study

Abstract Purpose Lateral extra‐articular tenodesis (LET) has gained increasing use as an adjunct to anterior cruciate ligament reconstruction (ACLR) to improve rotational stability and reduce graft failure. However, concerns remain regarding its potential impact on postoperative...

Measure Rigidity and Equidistribution for Fractal Carpets

Abstract Let $\theta $ θ be a Bernoulli measure which is stationary for a random walk generated by finitely many contracting rational affine dilations of $\mathbb{R}^{d}$ R d , and let $\mathcal{K} = \mathrm{supp}(\theta )$ K = supp ( θ ) be the corresponding attractor. An exampl...

Recruitment and Engagement in Care to Impact Practice Enhancement for Patients with Sickle Cell Disease: Study Protocol

Abstract Objectives To adapt an evidence-based linkage coordinator model used in HIV care to identify, engage, and link adults with sickle cell disease (SCD) who are unaffiliated from specialty care to SCD specialists, and to assess implementation readiness, processes, outcomes,...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

Medicaid ACO Implementation and Pediatric Asthma Care Equity

OBJECTIVES: Poorly controlled asthma disproportionately impacts children from lower-income and racially or ethnically minority groups. We examined whether Massachusetts Medicaid Accountable Care Organization (ACO) implementation was associated with improved pediatric asthma care...

Integrated Moisture-Swing Process for CO2 Capture and Release Using Non-Aqueous Absorbents

Abstract Moisture-swing CO2 capture has emerged as a promising low-energy alternative to conventional thermal/pressure/vacuum swings by exploiting humidity-driven shifts in carbonate/bicarbonate equilibria, most commonly in solid sorbents such as ion-exchange resins. Extending th...

Assessing Value of Behavioral Interventions: Designing Cost-Effectiveness Analyses for Food-Is-Medicine Interventions

Food-is-Medicine (FIM) interventions, including medically tailored meals, medically tailored groceries, and produce prescriptions, represent a promising approach to prevent, manage, and treat diet-related diseases. As the evidence base for FIM interventions expands through large-...

What bilingualism demands

Abstract Bilingualism research sits at the intersection of linguistics, cognitive neuroscience, and psychology, yet these disciplines often operate in relative isolation, limiting explanatory power and theoretical progress. This paper argues that deeper, more purposeful cross-fer...