University of Illinois Chicago

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass Spectrometry

Abstract Plasma proteomics has emerged as a powerful approach for interrogating human biology, identifying disease-associated proteomic changes, and advancing precision diagnostics. In recent years, affinity-based plasma proteomics platforms with predefined protein panels, such a...

Associations Between Physical Activity Measurement Modality and Gut Microbiome in Breast Cancer Survivors

Background/Objectives: Physical activity (PA), physiological fitness, and the gut microbiome have each been linked to health outcomes among breast cancer survivors (BCS); however, these associations have been inconsistent. Few studies have directly compared the associations of se...

Selective Hydrogenation of Styrene to Ethylbenzene over a Pd/Cu(111) Single-Atom Alloy Surface

Abstract The hydrogenation of styrene (C6H5CH═CH2) to ethylbenzene (C6H5CH2CH3) over a 0.1 ML Pd/Cu(111) single-atom alloy (SAA) surface was investigated under ambient pressure conditions using polarization-dependent reflection absorption infrared spectroscopy (PD-RAIRS). Gas-pha...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Deploying Meaningful Medical Informatics and Artificial Intelligence Solutions in the Clinical Field: A Call to Action for Researchers in Cardio-Oncology Informatics

Abstract Rapid advances in oncology care have resulted in a growing population of cancer survivors, many of whom suffer from short- and long-term cancer therapy related cardiovascular toxicities (CTR-CVT). Cardio-oncology aims to diagnose and manage these cardiovascular condition...

Defining the developmental exposome of the neonatal intensive care unit in preterm infants

Very preterm birth fundamentally reshapes the developmental exposome by shifting a substantial portion of gestation from the intrauterine environment to the neonatal intensive care unit (NICU), introducing a distinct constellation of nutritional, chemical, physical, and sensory e...

Priming the Brain Before Chemotherapy: Chronic Stress and HPA-Axis Dysregulation in Cancer-Related Cognitive Impairment

Cancer-related cognitive impairment (CRCI) is often attributed to chemotherapy, yet cognitive deficits are detectable in some patients before systemic treatment begins. This review examines a proposed two-hit framework in which cancer-related psychological and physiological stres...

American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Posterior Nasal Nerve Ablation

ABSTRACT The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence‐based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhini...

Childhood Trauma and Cognitive Outcomes in Adults with ADHD vs. ADHD with Internalizing Psychopathology

Childhood trauma can affect brain development, influencing memory and processing speed, particularly in adults with ADHD. A study involving 237 participants investigated how childhood trauma relates to cognition in adults with ADHD and internalizing disorders. The group consisted...

Fairness Invariants: A Relational Approach to Explaining and Mitigating Fairness Bugs

Data-driven software systems are increasingly deployed in high-stakes socio-economic domains, from criminal justice to financial lending. However, these systems often exhibit individual discrimination—unjustified disparities in which a program yields different outcomes for simila...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Agentic AI—Physicist Collaboration in Experimental Particle Physics: A Proof-of-Concept Measurement with LEP Open Data

We present an agentic measurement of the thrust distribution in \(e^+e^-\) collisions at \(\sqrt{s}=91.2\) GeV using ALEPH archived data. This work was carried out through an AI agent–physicist collaboration, using interactive natural-language prompting of Anthropic Claude and Op...

Field-driven hybrid filament formation governs switching in Ta–HfO2–Pt memristors

Memristive devices have gained significant attention for their potential in next-generation non-volatile memory and neuromorphic computing architectures. Among emerging candidates, transition metal oxides have proven particularly promising. While the switching mechanism in Ta/HfO...

Quasi‐isometries of relatively hyperbolic groups with an elementary hierarchy

Abstract Sela introduced limit groups in his work on the Tarski problem, and showed that each limit group has a cyclic hierarchy. In this paper, a class of relatively hyperbolic groups, equipped with a hierarchy similar to the one for limit groups, is shown to be closed under qua...

The Effects of Cognitive Flexibility on the Relation between Community Violence Exposure, Bilingualism, and Mental Health Symptoms in Latinx Youth

Abstract Latinx youth in the United States experience disproportionate exposure to community violence, which contributes to elevated rates of mental health symptoms. Research suggests that individual differences, such as cognitive flexibility (CF) and bilingualism, may serve as p...

“Eating traditional foods the traditional way”: constraining commodification in millet markets of India

Millets, traditionally a marginalized subsistence crop, are transforming into coveted health food commodities. Drawing on 12 months of ethnographic fieldwork in Delhi-National Capital Region, India, during 2023—the UN International Year of Millets—this article follows a critical...

Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cells

Abstract The increasing prevalence of chronic liver diseases (CLDs) is a global health concern. CLDs can cause fibrosis, and there is an urgent need for antifibrotic agents. The primary driver of fibrogenesis, transforming growth factor beta 1 (TGF-β1), activates hepatic stellate...

Characterizing meso-level organizations engaged in climate change adaptation work in Africa: A configurational analysis

Climate change adaptation in sub-Saharan Africa depends on the effectiveness of meso-level organizations (MLOs) in negotiating the needs of rural community beneficiaries and the aims of macro-level policy and finance actors. In this region, however, the traditional sector-based t...

Exploring future sustainable urban transport through scenarios: a critical review of contemporary practice

Under deep uncertainty, long-range transport forecasts are prone to inaccuracy. Scenario planning – a foresight approach from futures studies – offers a means to explore different long-range transport possibilities while also engaging transport stakeholders. Transport scenario na...

Opioid overdose risk and resilience among older Black men in Chicago: findings from community-based focus groups

Abstract Background Older Black/African American men experience the highest opioid overdose mortality rates in the United States. Prior research highlights structural inequities and service barriers shaping these disparities, yet few studies center the perspectives of older Black...