University of Illinois Chicago

Beyond LDL-C: Modern Lipid Management for ASCVD Prevention in Primary Care

Prevention of atherosclerotic cardiovascular disease (ASCVD) is fundamental for both cardiologists and primary care physicians. From risk estimation to medical therapy for primary and secondary prevention, management is evolving with increasing evidence. Risk estimation is moving...

Tele-Robotic Surgery for Combat Casualty Care

Objective: These experiments test the feasibility of tele-robotic surgery for the shipboard care of combat casualties. Summary Background Data: Limited research on the effects of telecommunications latency on tele-robotics has been a consistent concern in the growth of tele-robot...

Navigating the Unknown: The Sociocultural and Metacognitive Architecture of Wisdom

Psychological wisdom research has shifted from characterizing rare exemplars and desired outcomes to specifying processes that support sound judgment under uncertainty. Yet it has advanced along two siloed research tracks: one on folk theories-cultural tools such as exemplars, na...

Counteraction of HMGB1 at ss-dsDNA junctions maintains liquidity of protamine-DNA co-condensates

In the sperm nucleus, protamine replaces histones to mediate extreme DNA compaction. The histone-to-protamine transition involves the occurrence of double-strand breaks, and is facilitated by transition proteins including those containing high-mobility-group (HMG) boxes. Here we...

Efficacy and Safety of Time-Restricted Eating in Adults With Type 1 Diabetes: A Randomized Controlled Trial

OBJECTIVE: Many adults with type 1 diabetes (T1D) have overweight or obesity, underscoring the need for effective dietary weight loss strategies in this population. Time-restricted eating (TRE) has emerged as a popular approach for weight loss; however, its efficacy and safety in...

Dental Students' Use of Captions and Transcripts: Implications for ADA WCAG 2.1 Compliance

OBJECTIVES: This study examined how Doctor of Dental Medicine (DMD) students use captions and transcripts, their motivations for use, and their perceived learning benefits, with attention to accessibility and upcoming ADA compliance requirements. METHODS: A cross-sectional, anony...

Dual Burden of Community Violence and Policing in A Large Urban City

Abstract Marginalized urban communities are affected by both high levels of violence and pervasive police presence. This qualitative study examined the dual burden of violence and over-policing, which contributes to hypervigilance and stress among community members. To explore th...

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression

<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...

A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization

Abstract Asymptomatic gut colonization increases the risk of clinical infection and transmission by the multidrug-resistant pathogen Acinetobacter baumannii . Ornithine utilization was shown to be critical for A. baumannii competition with the resident microbiota to persist in gu...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Real‐time artificial intelligence‐based anatomy recognition in single‐port transvesical enucleation of the prostate

Objectives To evaluate the feasibility and accuracy of an artificial intelligence (AI) model to assist surgeons through automated real‐time detection and segmentation of key anatomical structures during robot‐assisted single‐port transvesical enucleation of the prostate (STEP). P...

Biomolecular Pathways Linking Preoperative Chronic Stress to Postoperative Cardiovascular Dysfunction in Noncardiac Surgery

Postoperative cardiovascular complications remain a leading cause of morbidity and mortality after noncardiac surgery, yet current risk models do not incorporate psychosocial stress. With over 300 million noncardiac surgeries performed annually worldwide and a substantial burden...

Defining risk: the case for conceptual clarity in acetaminophen poisoning

Despite the widespread availability of acetylcysteine, acetaminophen (paracetamol) poisoning remains the most common cause of acute liver failure and acute liver transplantation in the United State...

Crosstalk between SELENOF and the unfolded protein response in breast epithelium dictates cell fate

Abstract SELENOF is an understudied selenoprotein that contains selenium in the form of selenocysteine. Our previous findings indicate that SELENOF likely functions as a tumor suppressor in breast cancer; however, its precise molecular role and regulatory mechanisms remain poorly...

Comparing Provider Perspectives on Efficiency and Patient Safety With Paper and Digital Tools for Handoffs of Patient Care

OBJECTIVES: Handoffs of patient care are opportunities for promoting efficiency and safety. With the shift from paper to digital records, we examine changes in provider perceptions of efficiency, errors, and confidence on a labor and delivery service at an urban, academic hospita...

Examining Sex-Based Inequities in Pediatric Sports Medicine Research: A Systematic Review

BACKGROUND: Inequalities in the inclusion of male and female athletes have been documented in the sports medicine literature. However, the extent to which this phenomenon exists in studies of pediatric athletes remains poorly defined. The purpose of this study is to characterize...

“It’s why I’m the doctor that I am”: a qualitative study of the long-term outcomes of a longitudinal service-learning medical education program

Abstract Background Service-learning (SL) is widely used in medical education to promote structural competency and engagement with underserved communities. However, most SL evaluations focus on short-term outcomes, leaving limited understanding of whether these experiences shape...

How Healthy Are Community Health Workers: Findings from a Chicago-Area Survey

Community health workers (CHWs) are a growing and essential component of the U.S. healthcare workforce, yet little is known about their own health and well-being. The CHWs Our Work + Our Health Pilot Study administered a cross-sectional survey to a convenience sample of CHWs livi...

Exploring the protective role of school peers in substance use prevention among American Indian adolescents

Social network scholars have long recognized the role that social connections play in the substance use behavior of adolescents as they rely less on their parents/caregivers and more on their school peers. In this article, we explore the role of social networks as they relate to...

A Reproducible Evidence-Audit Framework for Leakage, Feature Stability, and Transportability in Translational Omics Classification

Submission-aligned code, outputs, figures, supplements, and manuscript for a reproducible evidence-audit framework in high-dimensional translational omics classification. A naive global-selection workflow is contrasted descriptively with a guarded nested workflow; because the arm...