University of Gothenburg

The Association of Umbilical Cord Blood Neurofilament Light With Nonreassuring Fetal Status: A Prospective Observational Study

( Int J Gynaecol Obstet . 2026 Mar;172(3):1491–1500. doi:10.1002/ijgo.70421) A prospective observational study explored whether neurofilament light (NfL), a marker of neuronal injury, can be reliably measured in umbilical cord blood and whether it is associated with nonreassuring...

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...

Dawn of the dinosaurs demonstrates early diversification bursts and a potential role for neutral dynamics during major evolutionary radiations

Abstract Major radiations have given rise to huge swathes of life on Earth, and understanding their dynamics reveals the process of biodiversity generation itself. The rise of dinosaurs and other archosaurs during the Triassic was a spectacular example of such a radiation; it set...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Spheroid cultures reveal cancer stem cell enrichment and distinct chemotherapeutic response in triple-negative breast cancer

Three-dimensional (3D) cancer spheroids mimic key morphological and biological features of solid tumors, providing a valuable model for evaluating drug responses. Here, we investigated whether intrinsic cancer stem cell composition and tumor subtype determine spheroid formation c...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born <27‐gestation wee...

Monte Carlo microdosimetry of 211at in multi-species thyroid follicle models: AlfaMC versus MCNPX and Geant4

Abstract Background Radionuclide therapy is an increasingly used treatment modality for patients with disseminated cancer diseases. Tumor-binding radiopharmaceuticals labelled with the alpha-particle emitter astatine-211 ( 211 At) are of interest to enable high radiation absorbed...

Fetal Alcohol Spectrum Disorder (FASD) and Harmful Sexual Behaviours or Sexual Offending: A Systematic Scoping Review

Abstract Previous research has shown that individuals with Fetal Alcohol Spectrum Disorder (FASD) are more likely to be overrepresented in the criminal justice system (CJS) compared to those without FASD. Criminal justice encounters can involve a range of harmful sexual behaviour...

Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells

Plasma membrane lipid asymmetry is tightly regulated and fundamental to mammalian cell physiology. TMEM30A is the β-subunit of P4-ATPases, flippase enzymes that maintain strict phosphatidylserine (PS) asymmetry by pumping it from the outer to the cytosolic leaflet. Loss of TMEM30...

Military medicine in transparent large-scale combat operations: rethinking medical timelines as operational planning variables

Large-scale combat operations (LSCO) are increasingly shaped by persistent surveillance, precision strike capability, electronic warfare, contested mobility and repeated attacks on healthcare personnel and facilities. These conditions challenge a core assumption of military medic...

Will work for sardines: 20 years of animal-borne ocean observing by Australia’s Integrated Marine Observing System (IMOS) Animal Tagging Facility

The world’s ocean stores ~90% of the excess heat generated by anthropogenic global warming, making sustained ocean observations essential for understanding physical, biological and climate processes. Here, we describe how the Integrated Marine Observing System (IMOS) Animal Taggi...

Phylogenetic Evidence of Local HIV-1 Transmission and Antiretroviral Drug Resistance in the Middle East and North Africa

The molecular epidemiology and antiretroviral (ARV) drug resistance of human immunodeficiency virus type 1 (HIV-1) remain incompletely outlined in the Middle East and North Africa (MENA). The aim of this retrospective molecular epidemiology study was to analyze MENA HIV-1 sequenc...

The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), a condition marked by inflammation and fibrosis that increases the risk of cirrhosis, liver failu...

Thermohaline gradients and frontal regimes in the northwestern Tropical Atlantic

Abstract. At the edge of the Amazon River plume, stirring by the North Brazil Current (NBC) and its eddies creates sharp surface thermohaline gradients on scales of O(1–100) km. This study provides a comprehensive picture of these gradients and fronts associated with the region's...

Economic Burden of Overweight and Obesity in Sweden: Current Estimates and Future Projections

ABSTRACT Aims Overweight and obesity are major public health challenges and well‐established risk factors for cardiovascular disease, cancer and premature mortality. We estimated the economic burden of overweight and obesity in Sweden in 2023 and projected the future economic bur...

Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers

Abstract Background Despite the high prevalence and clinical significance of emphysema, few genetic risk loci have been consistently replicated. We conducted a genome-wide association study (GWAS) of CT-based emphysema, with a particular focus on non-smoking-related genetic deter...

Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden

Abstract Patients with type 2 diabetes mellitus (T2DM) have elevated risk for aortic stenosis (AS). The impact of diabetes on prognosis and clinical progression in AS is not well documented. In this study we try to assess if patients with T2DM and AS have faster clinical progress...

Development and validation of natural language processing pipelines to extract injury and surgery-related data elements from ACL reconstruction operative reports

BACKGROUND: Over 100,000 patients undergo ACLR each year in the United States, providing rich electronic medical record data to improve outcomes, but manual chart review can be time-consuming and expensive. Natural language processing (NLP) methods have been successfully used to...

Lifestyle and psychosocial protective factors drive healthy aging and modulate inflammatory and metabolic pathways

Lifestyle habits, cognitive reserve, and affective reserve (secure attachment, extraversion, psychological resilience) predict resilience in the oldest-old, though the underlying biological mechanisms remain unclear. This study explored relationships between these protective fact...