University of Gothenburg

Employment status and occupation are associated with liver cirrhosis: A nationwide Swedish case–control study

Abstract Background Liver cirrhosis is often diagnosed in working‐age adults and carries a poor prognosis. A better understanding of variation by employment status and occupation may support earlier and more targeted diagnostic evaluation. Objectives To assess the odds of liver c...

YtrG is a functional part of the ytrGABCDEF operon and contributes to phenotypic heterogeneity in Bacillus subtilis

ABSTRACT The Bacillus subtilis ytrGABCDEF operon consists of the transcriptional repressor YtrA, the ATP-binding cassette transporter subunits YtrB, YtrC, YtrD, YtrE, and YtrF, likely forming two distinct transmembrane complexes (YtrB 2 CD and YtrE 2 F 2 ), and the small monotopi...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

The fast and the studious? Ramadan observance and student performance

Abstract We examine how religious observance affects educational performance by studying the years in which Ramadan overlapped with the national end-of-secondary-school exams in the Netherlands. Using administrative microdata and a difference-in-differences design, we find that s...

Beyond CD4 counts: Multi‐biomarker assessment of estimated time since HIV ‐1 infection and risk factors for late diagnosis

BACKGROUND: Late diagnosis (LD) of HIV, defined as CD4 count <350 cells/μL or AIDS at diagnosis, remains a substantial public health challenge, with half of individuals in Europe diagnosed late. How long these individuals have lived with HIV remains unclear. We applied a multi-bi...

Predictors of self-rated health in older adults: insights from an anchoring vignettes study

Abstract Self-rated health is one of the most used measures of subjective health in research. At the same time, it presents several methodological challenges. Self-rated health requires individuals to translate their complex, multifaceted health experiences into a single response...

Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults.

Inborn errors of type I interferon (IFN-I) immunity account for ∼7-8% of herpes simplex encephalitis (HSE) cases in young children, but the pathogenesis of HSE in adults is largely unknown. We report that IFN-I autoantibodies (auto-Abs) in serum/plasma samples drawn before, durin...

Maximum List r-Colorable Induced Subgraphs in $$kP_3$$-Free Graphs

We show that, for every fixed positive integers r and k, Max-Weight List r-Colorable Induced Subgraph admits a polynomial-time algorithm on $$kP_3$$ -free graphs. This problem is a common generalization of Max-Weight Independent Set, Odd Cycle Transversal and List r-Coloring, amo...

On the hunt for candidate genes involved in host-adaptation in Pseudomonas aeruginosa using comparative genomics

Abstract Background Pseudomonas aeruginosa is an opportunistic pathogen responsible for causing severe hospital-acquired infections, largely due to its adaptability, diverse range of virulence factors and drug resistance mechanisms. Despite extensive research, a substantial porti...

Promoting psychological resilience during the perinatal period with a digital tool (the HealthyMoms4MentalHealth-app): a study protocol for a randomised controlled trial in Sweden

Abstract Background Pregnancy and childbirth are major life transitions that can significantly impact women’s mental health, with depression and anxiety being the most commonly reported. International and Swedish studies estimate that up to one in four women experience anxiety or...

Real‐world use of automatic insulin delivery pumps in early pregnancy among women living with type 1 diabetes

Abstract Aims To investigate the clinical use, in early pregnancy in women living with type 1 diabetes (T1D), of automated insulin delivery (AID) systems lacking pregnancy‐specific algorithms and to evaluate the maternal and glycaemic outcomes associated with their implementation...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

A National Pediatric Cohort Study on In‐Hospital Cardiac Arrest in Sweden

ABSTRACT Background National data on pediatric in‐hospital cardiac arrest (pIHCA) are limited, and cohorts from highly specialized pediatric centers may not reflect the broader hospital population. We aimed to describe pIHCA reported across Swedish hospitals, with particular focu...

Act Consequentialism and Climate Esoteric Morality

Abstract It is often argued that no individual can make a difference to the amount of harm caused by climate change on her own, even though climate change results from all our emissions taken together. This “problem of inconsequentialism” is especially worrying for act consequent...

Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales

Abstract Background Digital cognitive testing and plasma biomarkers have emerged as key players for population screening and measuring drug efficacy in clinical trials for Alzheimer’s Disease (AD). Understanding test-retest reliability of these tools is essential to estimate mean...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Sexual health after childbirth: a qualitative study of women’s experiences

BACKGROUND: Sexual health is a vital component of overall well-being but receives limited attention in postpartum care. This study aimed to explore how pregnancy and childbirth shape women's experiences of sexual health, and to identify how care and support can be tailored to pro...

The 2026 ESC heart failure guidelines: advancing science while facilitating clinical implementation

The 2026 European Society of Cardiology (ESC) guidelines for the management of heart failure introduce a series of important changes intended to simplify classification, accelerate implementation of effective therapies, and shift care toward earlier prevention and intervention. A...

Screening of Brazilian Isolated Yeasts Reveals Multiple Potential Chassis for Industrial Biotechnology

ABSTRACT The future of sustainable industrial biotechnology relies on microbial hosts that can thrive where conventional strains fail. Although Saccharomyces cerevisiae remains the dominant industrial yeast, its metabolic constraints and stress sensitivity highlight the need for...