University of Gothenburg

Longitudinal Change and Tracking of Health-Related Physical Fitness in Adolescents Aged 12–16 Years: A Structured Narrative Review

Background/Objectives: The period between 12 and 16 years of age coincides with peak pubertal change, declining habitual physical activity, and the consolidation of lifelong behavioral patterns, making it a critical window for understanding how fitness develops and how stable (or...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...

Weighted Poisson intensity modelling for marked point processes with real-valued marks

Real-valued marks in spatial point processes are often analyzed separately from first-order intensity estimation or through assumptions specific to their generating mechanism. We propose a Weighted Poisson Intensity approach for incorporating real-valued marks into first-order in...

Select large language models outperform hip preservation experts on consensus‐based hip preservation questionnaire

Abstract Purpose Artificial intelligence (AI) is increasingly utilized in medical education and clinical contexts, yet few studies compare the performance of large language models (LLMs) to subspecialized experts in providing guideline‐based medical information on hip preservatio...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways

Abstract Septic shock represents the most severe form of infection-driven systemic inflammation, whereas acute pancreatitis induces a sterile inflammatory response. Although clinically similar, their molecular profiles may reveal distinct mechanisms underlying infectious and non-...

Childhood inductive reasoning, cardiovascular and cardiometabolic morbidity and dementia risk – a population representative cohort study across six decades

Abstract Background Higher cognitive ability in late adolescence and young adulthood associate with reduced risk of dementia, but such assessments are influenced by educational selection. Whether specific cognitive abilities earlier in childhood associate with later dementia risk...

Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization

Abstract Synapses, prototypic sites for neuronal communication, are key to brain function. Their organization and properties are instructed by synaptic cell adhesion molecules (sCAMs) that may operate independently or in coordination through yet unknown linker proteins. Here, we...

Who Should Pay? A Framework for a Fair Distribution of Climate Policy Burdens

We propose a normative framework for distributing the responsibility for national climate mitigation efforts among societal actors. The framework aims to inform national policy, emphasizing how justice considerations – alongside efficiency – can enhance public acceptance of clima...

FOR-HEALTH: study protocol for a randomized controlled feasibility trial of Structured Health Dialogues to improve lifestyle habits and metabolic health in forensic psychiatric inpatients

Abstract Background People with severe mental illness demonstrate markedly reduced life expectancy, largely due to preventable cardiometabolic disease. This burden is particularly pronounced in compulsory forensic psychiatric care, where prolonged inpatient stays, restrictive env...

Interplay between the role of DNA methylation in regulating gene expression and TE-silencing in a reptilian methylome

Abstract DNA methylation is a major component of eukaryotic genomes with an important role in the defence against transposable elements, to transcriptionally silence their activity and prevent transposition. DNA methylation also plays a major role in the regulation of gene expres...

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

Abstract Polycystic ovary syndrome (PCOS) is characterized by reproductive and metabolic disturbances and is associated with increased symptoms of anxiety and depression. Circulating adiponectin, an insulin-sensitizing adipokine, is reduced in women with PCOS, and low adiponectin...

Periodic reassessment or permanent approval? A critical analysis of the EU Commission’s proposal to reform pesticide and biocide authorisation in Europe

Abstract On 16 December 2025, the European Commission published proposal COM(2025) 1030 within the Food and Feed Safety Simplification Omnibus, aiming to amend Regulation (EC) No 1107/2009 on plant protection products and Regulation (EU) No 528/2012 on biocidal products. The prop...

Genomic consequences of admixture in an experimentally founded sand lizard population

Abstract Conservation interventions are increasingly required for species threatened by population declines and isolation due to anthropogenic pressures. Small, isolated populations are particularly vulnerable to the loss of genetic diversity, increased inbreeding, and the accumu...

Trismus and Health‐Related Quality of Life in HNC Patients up to 10 Years Post‐Radiotherapy Completion

ABSTRACT Background This prospective study investigates trismus prevalence, quality of life (QOL), and trismus‐related symptoms in HNC patients up to 10 years post‐radiotherapy (RT). Methods A total of 211 patients with HNC receiving RT were followed pretreatment, 12, 60, and 120...

Movement of European freshwater mussels under simulated dewatering conditions

Freshwater ecosystems are exposed to altered hydrological regimes due to climate change and poor water management, resulting in frequent and intense dewatering events. Freshwater mussels (Unionida) are particularly vulnerable to rapid water-level declines. Dewatering can lead to...

The Impact of Out-of-Hours Liver Transplantation on Outcomes

Objectives: This national, multicenter retrospective study of 764 adult liver transplantations (LT) in Sweden (2019–2023) employed a data-driven approach to identify the out-of-hours (OOH) high-risk window and evaluate its impact on patient outcomes and health care costs. Summary...

Autonomy in Prison: Street-Level Bureaucrats Re-Connecting with Their Purpose

Policy alienation research highlights how public professionals experience powerlessness and meaninglessness when policies misalign with their professional values and work context. While previous research conceptualizes policy alienation as a largely static condition, this article...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Evaluation of the Psychometric Scale Properties of Reflective Functioning Questionnaire (RFQ-8) in Persons with Schizophrenia Spectrum Disorders and Healthy Controls

There is a need to effectively measure mentalization in people with Schizophrenia Spectrum Disorders (SSD) due to its relevance for delusions and hallucinations. The RFQ-8 appears to be an easy-to-administer screening tool for mentalization, but its factor structure is debated. I...