University of Cambridge

JPResUnet: A joint probability density function translation model in partially premixed flames

Machine learning (ML) for turbulent combustion modelling can offer high fidelity within the training regime, yet its robustness under unseen conditions remains a practical concern. Conversely, established presumed probability density function (PDF) approaches are generally robust...

Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics

Abstract Genetic circuits with only a few components can generate complex gene regulatory dynamics. Here, we combine stochastic modelling and single-cell time-lapse microscopy to reveal the possible dynamics generated by a key gene circuit motif: the mixed positive/negative feedb...

Data‐Driven Materials Science for Energy‐Sustainable Applications

Materials science is underpinned by structure-property relationships that govern the function of a material. These relationships can be encoded into algorithms and integrated into machine-learning models that enable the prediction of materials and their cognate properties. Howeve...

Package Managers à la Carte: A Formal Model of Dependency Resolution

Package managers are legion. Every programming language and operating system has its own solution, each with subtly different semantics for dependency resolution. This fragmentation prevents multilingual projects from expressing precise dependencies across language ecosystems; it...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Long-term outcomes of first episode affective psychosis in postpartum women

BACKGROUND: Outcomes of first episode postpartum psychosis and their distinction from outcomes of non-postpartum psychosis are poorly characterised. AIMS: To characterise the disease course and outcomes of first episode postpartum psychosis, compared with first episode non-postpa...

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

Abstract Naked mole-rats (NMRs, Heterocephalus glaber ) display unusual longevity and resistance to age-related decline, and accumulating evidence suggests that their autophagy–lysosome pathway (ALP) is regulated differently from that of conventional mammalian models. However, mo...

Qualitative Data Sharing with Care: A Concise Guide

Created by the Materialising Open Research Practices in the Humanities and Social Sciences (MORPHSS) project, this resource offers guidance on how to make decisions around whether and how to share qualitative data in ways that carefully negotiate the needs and requirements of dif...

Early warning and advisory can contribute to enhanced wheat stem and yellow rust management in Ethiopia

Abstract Wheat rusts are major constraints for global wheat production, leading to substantial yield and economic losses. To mitigate rust related production risks, disease forecast models generate time and location-specific information on the emergence and spread of wheat rusts....

Properties of Multidimensional Vector Zeckendorf Representations

A generalization of Zeckendorf’s theorem states for integer k≥3, every nonnegative integer has a unique k-Zeckendorf representation as a sum of distinct k-bonacci numbers, where no k consecutive k-bonacci numbers are present in the representation. Anderson and Bicknell Johnson ex...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

An Energy-GradientStrategy for Triplet-Pair Separationin Singlet-Fission Oligomers

Abstract Singlet fission (SF) offers a pathway to surpass the Shockley–Queisser limit by converting one photoexcited singlet exciton into two triplet excitons. However, in molecular assemblies, this process commonly yields a strongly exchange-coupled correlated triplet pair, 1(TT...

Trace-element enrichment in agricultural soils under wastewater-influenced surface-water irrigation: a plot-scale study in an Andean micro-watershed

Abstract The use of wastewater-influenced surface waters for agricultural irrigation is common in many regions, yet its implications for soil geochemistry remain insufficiently characterized, particularly in Andean micro-watersheds. This study evaluates the occurrence and distrib...

The tradition of washing hands in a common bowl before eating: a qualitative study of the practice of communal bowl hand rinsing before mealtimes, in rural and urban Mali

<title>Abstract</title> Background Diarrhoeal disease is a leading cause of death in children under 5 years old globally, despite being largely preventable. It is widely known that individual handwashing with soap is key in preventing transmission of enteric pathogens. Communal b...

Adherence to the Eatwell Guide and associations with markers of adiposity: a prospective analysis within the UK Biobank cohort

Abstract Background Obesity remains a major public health concern in the UK, contributing towards increased disease risk and premature mortality. The Eatwell Guide - the UK’s health eating model - is widely applied in policy and practice, yet evidence linking adherence to this di...

Global Disparities in the Recreational Fishery Economy: A Systematic Review

Recreational fisheries contribute significantly to global economies through tourism, employment, and ecosystem service valorization. However, a systematic understanding of their economic magnitude and regional disparities remains fragmented. This study conducts a systematic revie...

Programmable multifunctional microrobots for synergistic cuproptosis-immunotherapy

Abstract Oral microrobots as drug carriers have shown great promise in enhancing the therapeutic efficacy of colorectal cancer (CRC). However, existing platforms frequently lack the programmable temporal precision required to execute complex, multi-stage dosing regimens. Here, we...

The Effects of Non-Premixed Hydrogen on Soot Formation in an Ethylene-Fuelled Laboratory-Scale Rich-Quench-Lean Combustor

Abstract This work investigates the effects of hydrogen blending on soot formation and flame structure in a laboratory-scale Rich-Quench-Lean (RQL) burner using ethylene-hydrogen mixtures (0-50 vol.% hydrogen) at constant carbon mass flow rate. Laser-induced incandescence and sin...

Collision dynamics of false-vacuum oscillons

A bstract We study the collision dynamics of localized oscillons in two classes of (1 + 1)-dimensional scalar field theories with metastable false vacua, a normal class with a positive quartic self-interaction term and an inverted class with a negative quartic term. We construct...

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...