University of British Columbia

Checkerboard-type Zhang-Rice states in overdoped cuprate superconductors

Abstract Cuprate superconductors remain central to condensed matter physics due to their technological relevance and unconventional, incompletely understood electronic behavior. While the canonical phase diagram and low-energy models have been shaped largely by studies of underdo...

Closeness and Well-Being in Older Adulthood: A Dyadic Daily Diary Study

Relationships are central to well-being. Relationship closeness, which measures interdependence, remains underexplored in older adult couples managing chronic health conditions. In a sample of 146 distinguishable dyads consisting of individuals with chronic back pain (ICBPs) and...

Cross-platform Bayesian deconvolution of MeDIP-seq reveals tissue-specific and cancer-associated methylation signatures

Abstract DNA methylation profiling of cell-free DNA is increasingly used for tissue-of-origin analysis and cancer detection, but quantitative interpretation of enrichment-based sequencing data remains a major challenge. MeDIP-seq provides scalable, cost-effective profiling of low...

A dilemma for skeptics of trustworthy AI

Can artificial intelligence (AI) ever be (un)trustworthy? A growing number of philosophers argue that it cannot, because AI lacks some feature deemed essential for the trust relation, such as moral agency or being responsive to reasons. Here we propose a dilemma for these skeptic...

Arts-Based Memory Cafés as Participatory Action Research: A Methodologial Framework for Dementia-Inclusive Community Development

Background Participatory Action Research (PAR) and Arts-Based Research (ABR) have increasingly been recognized as promising approaches for dementia-inclusive community engagement. However, existing studies often treat arts activities as supportive interventions rather than method...

Nesting biology of Nyctiphrynus rosenbergi and Nyctiphrynus ocellatus

The nesting biology for the genus Nyctiphrynus within the family Caprimulgidae is understudied, specifically the choco poorwill (Nyctiphrynus rosenbergi) and ocellated poorwill (Nyctiphrynus ocellatus). We provide the first description of the nesting biology of N. rosenbergi and...

Intraoperative Venous Congestion in DIEP Flap Reconstruction: A Pooled Analysis Demonstrating the Limited Predictive Value of Patient-Level Risk Factors

Introduction Intraoperative venous congestion complicates 2% to 20% of deep inferior epigastric perforator flap breast reconstructions (DIEP) and is attributed to persistent superficial venous dominance. Despite numerous proposed predictors, no consensus exists. This study aims t...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Discovery, Design, and Evaluation of Nanomolar to Picomolar Inhibitors of Human Pancreatic α-Amylase for Control of Postprandial Blood Glucose Levels

Conspectus Type 2 diabetes is a disease that is rapidly expanding across the world with global cases quadrupling since 1990 and now comprising over 800 million people, the majority of whom are in low- and middle-income countries (Zhou et al.Lancet2024, 404, 2077–2093.). The poor...

Patient-facing artificial intelligence in primary health care: a scoping review of literature through early 2025

Abstract Background Patient-facing artificial intelligence (AI) tools are increasingly accessible to the public, but evidence on their development and impact in primary health care (PHC) remains limited. This study aimed to map the literature on patient-facing AI tools in PHC, in...

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy in Lung Cancer and Lung Metastases: A Systematic Review

Background/Objectives: Personalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR) delivers high-dose stereotactic radiation as temporally separated pulses, permitting interval response assessment, adaptive replanning, and integration with systemic therapy. Its rol...

In-water recompression for severe decompression illness in competitive freediving: a case report

Introduction: Decompression illness (DCI) is a recognised risk of freediving. When timely hyperbaric oxygen therapy (HBOT) is unavailable, oxygen-based in-water recompression (IWR) may be considered. Methods: A 49-year-old competitive freediver developed severe neurological DCI w...

Unseen barriers to home healthcare: a qualitative study of providers’ perspectives from Saudi Arabia

This study investigated the challenges of providing care in Home Health Care (HHC) settings in Saudi Arabia. We employed a qualitative design and used thematic analysis to identify patterns and themes in the data supplemented with selected techniques commonly associated with grou...

Beta Atlas: Charting Global Production of Nonconventional β − -Emitters for Targeted Radiopharmaceutical Therapy—Part 1

β-minus particle (β−)–emitting radionuclides have long been central to targeted radiopharmaceutical therapy. Interest in expanding their repertoire beyond conventional options has grown over time, as the need for radionuclides with different emission profiles and theranostic pote...

A medically grounded LLM agent–based tool to detect patient safety events in medical records

Large language models (LLMs) have shown incredible promise in medicine. While LLMs may be particularly useful in areas requiring extensive review of clinical records, their use remains limited due to their tendency to hallucinate and fabricate information. Hallucination issues, a...

Joint Distributions of Error Terms for Primes in Arithmetic Progressions Modulo 11

We provide a formula for the logarithmic density of the set of positive real numbers on which two prime counting functions $ψ(x;q,a)$ and $ψ(x;q,b)$ are simultaneously larger than their asymptotic main terms, as well as a method for calculating the numerical values of such densit...

Ten rules to increase the usability of earth observation mission datasets

Abstract Publicly-funded Earth Observation (EO) missions present unprecedented challenges and opportunities for observing our changing planet and applying the knowledge gained to benefit society. As EO mission data continue to grow in volume and complexity, a paradigm shift in ho...

Presence and abundance of airborne Botryosphaeriaceae conidia are governed by temperature and season in the Okanagan Valley, Canada

BACKGROUND: Grapevine trunk diseases (GTDs) are one of the most important diseases in grapevines, threatening vineyard longevity and productivity worldwide. However, regional patterns of airborne inoculum remain poorly understood for many production areas, including the Okanagan...

A Finite-Difference Summation-by-Parts Conditionally Stable Partitioned Algorithm for Conjugate Heat Transfer Problems

Abstract In this work, we design and analyze a novel, provably conditionally stable weakly coupled partitioned scheme to solve the conjugate heat transfer (CHT) problem. We consider a model CHT problem consisting of linear advection–diffusion and heat equations, coupled at an int...

Revealing the genetic mechanisms underpinning the parasite-induced water-seeking behaviour of insects through RNA-seq

Abstract Water-seeking behaviour in arthropods infected by mermithid nematodes or nematomorphs is a classic example of host manipulation, yet its molecular basis remains poorly understood. We investigated mechanisms underlying this aberrant behaviour in European earwigs (Forficul...