University of British Columbia

Resilience and Protective Factors for Mental Health among Indigenous Youth in Canada: A Scoping Review

Abstract Indigenous youth’s inherent strength and resilience play a vital role in their well-being and mental health. Protective factors, closely linked to resilience, spanning individual, family, and community levels reinforce positive mental health outcomes. The purpose of the...

Stereoselectivity inLiquid Aerosols through Acid-MediatedEpoxide Ring-Opening Reactions

Abstract Stereoisomers in aqueous atmospheric aerosols are assumed to be present in equal concentrations, as aerosols are most commonly mixtures of simple inorganic salts with a range of organic species that lack obvious pathways to induce stereoselectivity. Further, since submic...

Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents

Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both the potential and the limitations of this strategy. First-generation polymeric st...

A collaborative e-library for stressor-response functions to improve the science underlying salmonid management

Stressor-response functions quantify relationships linking environmental stressors to biological responses, underpinning salmonid life-cycle models, restoration planning, regulatory policy, and cumulative effects assessments. Despite their importance, these stressor-response func...

Lamotrigine and other therapy-associated HLH syndromes: a review

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation that can occur secondary to medical interventions including immunomodulatory therapies such as immune checkpoint inhibitors and stem cell transplantation. However, lamotrigine and...

Cost-effectiveness of lenacapavir versus tenofovir disoproxil fumarate plus emtricitabine for pre-exposure prophylaxis to prevent HIV-1 transmission in gay, bisexual, and other men who have sex with men in Spain

Background Lenacapavir (LEN), a twice-yearly subcutaneous capsid inhibitor, has demonstrated superior efficacy over daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) in clinical trials. No European cost-effectiveness analyses...

Migraine-Associated Tinnitus and Vestibular Symptoms: a Clinical Synthesis and Conceptual Framework

Abstract Purpose of Review Migraine is increasingly recognized as a multisensory neurologic disorder whose manifestations extend beyond headache to include tinnitus, aural fullness, dizziness, vertigo, and motion sensitivity. This review synthesizes current clinical and mechanist...

Casting light on the workings of illegal fishing markets

About 3.5 million fishing vessels ply the world’s oceans, providing livelihoods and food for millions of people. Sound management is key to fisheries’ sustainability, but illegal fishing, along with fishing overcapacity generally and environmental change, are putting many fisheri...

Early‐Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet‐Induced Metabolic Syndrome in Young Rats

OBJECTIVE: Dairy consumption plays a protective role in obesity that may be mediated through the gut microbiota. This study examined the role of dairy proteins, casein, whey, and complete dairy (skim milk powder), and a plant-based alternative, soy, on gut microbiota composition,...

The Database of Religious History as an Open-Access Digital Resource for the Study of the Ancient Mediterranean World

In the current digital world, there is an incredible amount of information at our fingertips. In fact, there is so much information that the sheer amount of data can be overwhelming. As historians, archaeologists, and cultural heritage experts, a significant amount of research or...

Salt‐Controlled Multistep Phase Separation in Hydroxypropyl Cellulose Colloids for Sustainable Adhesives

ABSTRACT Phase separation is an evergreen subject that shapes our understanding of how order and functionality emerge from disordered complex soft matter systems. Here, we report on the salt‐regulated transition from isotropic liquid‐liquid phase separation to anisotropic liquid‐...

Neurological Pupil Index and Outcome After Cardiac Arrest in Children: Single-Center, Retrospective Cohort, 2018–2023

OBJECTIVES: To determine the association between abnormal pupillary reactivity using automated infrared pupillometry and unfavorable outcome after pediatric cardiac arrest (CA). DESIGN: Single-center, retrospective, cohort study, 2018-2023. SETTING: Large tertiary PICU in the Uni...

Conformational Analysis and Ultraviolet Photodissociation of Valine in Solid Parahydrogen: Conformer-Specific Photolysis and Product Identification

The conformational composition and ultraviolet photochemistry of neutral valine isolated in solid parahydrogen were investigated using high-resolution infrared spectroscopy, ultraviolet photolysis, and density functional theory calculations. The observed infrared spectrum was ana...

Spatial patterns and factors associated with vaccination uptake at follow-up among previously identified zero-dose children in Mchinji District, Malawi

Globally, more than 14 million infants remained zero-dose in 2024, having not received the first dose of diphtheria-tetanus-pertussis-containing vaccine (DTP1). In Malawi, national immunisation estimates may mask sub-district inequities, limiting the ability to identify and reach...

Air Pollution Education: A Novel Curriculum for Pulmonary Fellows

Abstract Background Air pollution plays a significant role in human health, impacting respiratory outcomes. Despite decades of evidence detailing these health consequences as a result of both short and long-term air pollution exposure, the harms of air pollution exposure are infr...

Bridging the social license gap: How community-directed communication shapes risk perception and acceptance of carbon capture and storage in the United States

Achieving global climate targets demands rapid deployment of new technologies, yet technological readiness risks outpacing the social license needed for deployment. Carbon capture and storage (CCS) exemplifies this challenge: deployment is expanding rapidly, but public awareness...

Dental caries experience in first permanent molars and its associated factors among Iranian primary school-aged children: a cross-sectional study

Abstract Background Dental caries in first permanent molars is a highly prevalent condition in primary school-aged children and represents a substantial oral health burden in Iran. This study aimed to assess dental caries experience, based on the decayed, missing, and filled teet...

Using long-axial field-of-view dynamic PET/CT data to generate synthetic contrast enhanced CT images

ABSTRACT Purpose Dynamic whole-body [ 18 F]FDG PET/CT (DWB-PET/CT) imaging performed on long-axial field-of-view (LAFOV) systems enables the simultaneous assessment of tracer delivery and metabolism across extended anatomical regions. We investigated whether tracer delivery infor...

Social connection and disconnection: Older adults’ life course perspectives on information and communication technologies

Abstract Background and Objectives Research has established that while most older adults use information and communication technologies (ICTs), loneliness and social isolation in later life is a pressing issue. Studies of older adults’ ICT use has largely been cross-sectional, fo...

The symbolic power of decriminalization and recriminalization in shaping stigma toward people who use drugs in British Columbia

In January 2023, British Columbia (BC) implemented a three-year decriminalization pilot to reduce harms of drug criminalization and address stigma toward people who use drugs. In May 2024, the policy was amended to “recriminalize” drug possession, a reform that excluded most publ...