University of British Columbia

Socio-hydrogeology: The past, present, and future of a people-centred and place-based approach to groundwater science

Groundwater systems are shaped by deeply interwoven physical processes and social dynamics, yet traditional hydrogeological approaches have often treated these domains separately. Over the past decade, socio-hydrogeology has emerged in response, offering an approach that systemat...

Occupational HPV Exposure in Otolaryngology: A Scoping Review of Detection, Risk, and Prevention

OBJECTIVES: To characterize the current evidence regarding occupational human papillomavirus (HPV) exposure in otolaryngology, including mechanistic evidence of plume contamination, clinical evidence of infection among healthcare workers, and preventive practices related to perso...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

Profiles of active transportation injury survivors: findings from a British Columbia inception cohort

Active transportation (AT) uptake is increasing as a result of its beneficial effects on health and the environment. Active transport injury (ATI) events that do not involve a motor vehicle are common but go unreported in traffic injury databases. This manuscript reports sociodem...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Granzymes in Neuroinflammation and Neurodegenerative Diseases

Abstract Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these se...

“I know how important it is”: A qualitative analysis of participants’ experiences in a vaccine safety study

Specialist immunization clinics can support vaccination counseling for individuals experiencing adverse events following immunization (AEFIs) and research into AEFIs. We sought to describe the experiences of participants from the Canadian Special Immunization Clinic Network COVID...

The distribution and origin of Mercury’s crustal magnetization

Mercury is the only planet other than Earth to possess both a global magnetic field that arises from a core dynamo, and a crustal magnetic field that arises from magnetized rocks. Crustal fields provide unique records of a planet’s interior state and evolution because magnetizati...

Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation

Large language models (LLMs) are increasingly adapted for medical applications, but most are trained using data from a single institution because privacy and governance constraints prevent multi-institutional data sharing. As a result, these models often generalize poorly across...

Strategic Redirection: AI as Tool and AI as Mineral Kin in Indigenous Futures

This is the second foundational paper of the Meta-Relationality and Artificial Intelligence Research Project at the University of Victoria. This article approaches artificial intelligence from the position of an Indigenous person who engages it strategically. I do not understand...

Strategic Redirection: AI as Tool and AI as Mineral Kin in Indigenous Futures

This is the second foundational paper of the Meta-Relationality and Artificial Intelligence Research Project at the University of Victoria. This article approaches artificial intelligence from the position of an Indigenous person who engages it strategically. I do not understand...

Effectiveness of a near-peer teaching model in an otolaryngology bootcamp for medical students: a pilot study

<sec><title>Background:</title> Studies show that near-peer, simulation-based training can help develop technical skills. We sought to examine the effectiveness of near-peer instruction in otolaryngology emergencies by assessing student knowledge and procedural confidence before...

Lessons learned from a Kaggle challenge for particle picking in cryo-electron tomography

Abstract The difficulty of particle picking in cryo-electron tomography remains a barrier to routine in situ structure determination. Machine learning is well-suited to overcome this bottleneck with efficient algorithms that generalize across molecular species. To spur new algori...

A process evaluation of a randomized clinical trial of selective decontamination of the digestive tract in ventilated adults admitted to intensive care: the SuDDICU PE study

The SuDDICU trial evaluated the effectiveness of selective digestive decontamination (SDD), a prophylactic antibiotic regimen comprising oral, gastric and intravenous (IV) components in ventilated adults admitted to intensive care. The trial recruited 9289 participants in 26 clus...

Towards clinical implementation of artificial intelligence in cancer care: concept mapping analysis of provincial workshop findings

Abstract Background Artificial intelligence (AI) has rapidly garnered interest in healthcare. Cancer care’s multidisciplinary nature and high coordination demands are well positioned to benefit from AI. While attitudes toward implementation of AI in medicine have been explored ge...

Genomic catalogue of giant viruses reveals expanded diversity and functional potential

Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 species-level representatives from 18,727...

Development and validation of an amyloid PET dementia of the Alzheimer's type (DAT) score

Background Alzheimer's disease (AD) can be debilitating if left untreated, but its progression may be altered through early detection. Objective To develop and evaluate a convolutional neural network (CNN) for detecting AD from amyloid PET brain images and to investigate the regi...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Resilience and Protective Factors for Mental Health among Indigenous Youth in Canada: A Scoping Review

Abstract Indigenous youth’s inherent strength and resilience play a vital role in their well-being and mental health. Protective factors, closely linked to resilience, spanning individual, family, and community levels reinforce positive mental health outcomes. The purpose of the...

Engaging primary care teams with patient-reported data: design, acceptability and outcomes of a structured intervention

Abstract Background Although patient-reported data are increasingly available and their usefulness is recognized, these measures are not well integrated at the clinical levels of primary care. Also, the processes through which these data are translated into actionable insights fo...