University of Bari Aldo Moro

What are the Unmet Needs in Managing Digestive Neuroendocrine Carcinomas?

This review highlights the major unmet needs in diagnosis and treatment of digestive neuroendocrine carcinomas (NEC) and describes the current and evolving evidence on these aspects. Improved pathological criteria are needed to accurately diagnose NEC and distinguish this entity...

Alzheimer's Co‐Pathology Burden on Basal Forebrain Atrophy and Cognitive Impairment in Dementia with Lewy Bodies: A Cross‐Sectional Pilot Study

OBJECTIVE: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co-pathology on basal forebrain (BF) atrophy and it...

Adenomyosis and Uterine Fibroids: Two Distinct Yet Overlapping Clinical Entities

Adenomyosis and uterine fibroids are among the most common benign uterine disorders in women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic pain, and infertility. Despite their distinct histopathological features, they frequently coexist and s...

Detection and differentiation of Babesia banethi and Babesia vulpes in foxes and potential tick vectors by a duplex real-time PCR assay

The increasing interactions among wildlife, domestic animals, vectors, and humans are reshaping the epidemiology of vector-borne diseases, including babesiosis. Among piroplasmids infecting wild canids, Babesia vulpes is widely distributed in red foxes, whereas many scientific as...

Biosimilars in chronic spontaneous urticaria: current evidence, clinical implications and future perspectives

Chronic spontaneous urticaria (CSU) is a debilitating condition characterized by recurrent wheals and/or angioedema lasting more than six weeks without identifiable triggers. The global prevalence is increasing, and patients with resistance to antihistamine therapies experience a...

REE-depleted anatectic marble reveals the primary source of crustal carbonatites

Crustal-derived carbonatitic melts are increasingly recognised in high-grade terrains, but their residual source rocks remain largely unexplored. As a result, the crustal origin of carbonatites is generally constrained from geochemical signatures of the crystallised melts without...

Exosomes and the NLRP3 Inflammasome: A Bidirectional Axis in Cellular Signaling and Vesicle Trafficking in Health and Disease

Exosomes are small extracellular vesicles (EVs) generated through the endosomal pathway that mediate intercellular communication by transferring proteins, lipids, and regulatory RNAs. In parallel, the NLRP3 inflammasome is a key signaling platform of the innate immune system that...

The Acceptance of Relationship Red Flags and Romantic Myths in Adolescents’ Judgments of Teen Dating Violence: A Cross-Sectional Vignette Study

Teen dating violence (TDV) is a prevalent phenomenon, yet the role of cognitive–attitudinal factors such as the acceptance of relational “red flags” and the endorsement of romantic myths remains insufficiently explored. This study investigates how these factors are associated wit...

Conditional cooling from large-scale urban afforestation: ecosystem functioning and planning implications

Large-scale urban afforestation is increasingly promoted as a Nature-Based Solution for reducing urban heat. Yet afforestation does not cool cities uniformly, and the conditions under which it delivers sustained thermal benefits remain poorly understood. This uncertainty limits t...

Epiretinal Human Amniotic Membrane Overlay for Recurrent Retinal Detachment in Highly Myopic Eyes with Peripapillary Breaks over Chorioretinal Atrophy: Surgical Technique and Outcomes

Purpose: To evaluate the anatomical and functional outcomes of an epiretinal cryopreserved human amniotic membrane (hAM) overlay technique for the management of recurrent retinal detachment (RD) associated with peripapillary breaks in highly myopic eyes. Methods: Retrospective in...

Violence against women: a pilot study on the perception of Apulian High School students

Abstract Violence Against Women (VAW) is a widespread issue deeply rooted in social and cultural structures. Affecting women of all ages and backgrounds, VAW is often underreported due to stigma and victim-blaming. This study explores young people’s perceptions of VAW in the Apul...

Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer

Abstract Small cell lung cancer is one of the most aggressive malignancies, characterized by rapid tumor growth, early metastatic spread and extremely poor survival. Although most patients initially respond to platinum-based chemotherapy, relapse is almost inevitable and treatmen...

The Worldwide Burden of Parkinson's Disease Is Growing, but Its Incidence Is Not: Lessons from Population‐Based Studies

Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Supporting Information. COI_disclosure. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the aut...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Potential of temperate agroforestry systems to deliver ecosystem services: An evidence map

Abstract. Agroforestry systems are promoted as multifunctional land-use strategies, yet evidence of their benefits, especially in temperate regions, remains fragmented. This umbrella review maps 42 meta-analyses to quantify the effects of agroforestry on environmental, climate, a...

Segregated solutions for a critical Choquard system with a small interspecies repulsive force

Abstract We consider the following elliptic system $$\begin{aligned} -\Delta u_i=(|x|^{-\mu }*|u_i|^{4-\frac{\mu }{2}})|u_i|^{2-\frac{\mu }{2}}u_i+\sum _{j=1\, j\not =i}^2\beta u_iu_j^2\quad \hbox {in} \, \, {\mathbb {R}^4},\quad i=1,2. \end{aligned}$$ - Δ u i = ( | x | - μ ∗ | u...

Assessing hope in preadolescents: the role of gender and validity of the Italian Children's Hope Scale

The psychological construct of hope, defined as a dynamic cognitive motivational system, is a predictor of psychological strength, well-being and flourishing across children, adolescents and adults. As a positive internal resource, hopeful thinking should be evaluated and fostere...

Wine tourism and sustainable regional development: A triple bottom line perspective

Wine tourism is increasingly recognized as a driver for value creation in wineries. The main objective of this research is to analyze the economic, social, and environmental effects of wine tourism at the firm and the regional levels. The methodology used is the case study. The f...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...