University of Bari Aldo Moro

VEGF pathway signalling across pulmonary neuroendocrine tumours: associations with histological subtypes in a multicentre study

Abstract The current classification of pulmonary neuroendocrine neoplasms (NENs) is primarily based on histomorphological criteria, which do not fully capture their underlying biological heterogeneity. This limitation is particularly evident among pulmonary carcinoids, a subgroup...

Who Bears the Burden? The Digital Omnibus and the Redistribution of Supervisory Costs

Abstract The Digital Omnibus package is presented as a technical simplification of the digital rulebook, with significant estimated savings for both businesses and public administrations. Its accompanying analysis, however, measures only the cost lifted from regulated entities: o...

N-Adamantyl-1-Pentyl-4-Oxo-1,4-Dihydroquinoline-3-Carboxamide and N-(Adamantan-1-Yl)-2-(Alkyloxy)benzamide Derivatives as Fluorescent Probes for Selective CB2R Targeting

Background/Objectives: The cannabinoid receptor subtype 2 (CB2R) is an increasingly important therapeutic and diagnostic target because of its involvement in inflammation-associated disorders, including cancer and neurodegenerative diseases. CB2R biology has traditionally been in...

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...

The Role of Targeted Rehabilitation in Enhancing Recovery After Total Hip Arthroplasty with Anterior Minimally Invasive Surgery Approach: A Retrospective Pilot Study

Background: Hip osteoarthritis is a highly prevalent degenerative condition and a leading indication for total hip arthroplasty (THA). As anterior approaches have gained popularity, optimizing postoperative rehabilitation according to the muscles involved in recovery has become i...

Pembrolizumab-related hand and foot skin reaction

Hand and foot skin reaction (HFSR), usually associated with tyrosine kinase inhibitors, is characterized by painful erythema and hyperkeratosis at palmoplantar pressure points. HFSR differs from the more widely recognized chemotherapy-induced hand-foot syndrome (HFS) in terms of...

Quantitative Digital Image Analysis Detects Differences in Nuclear Features Between CK20-Negative and CK20-Positive Merkel Cell Carcinomas

Abstract: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy that can arise through 2 oncogenic pathways: a Merkel cell polyomavirus–positive pathway and a virus-negative pathway driven by ultraviolet exposure. Cytokeratin 20 (CK20), expressed i...

Pore-engineered mesoporous silica nanocarriers for sustainable, stimuli-responsive corrosion-inhibitor release

Corrosion of metallic materials, particularly in heritage structures and concrete-based infrastructures, remains a persistent challenge, necessitating protection strategies that are effective, long-lasting, environmentally sustainable, and compatible with heterogeneous substrates...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Language of Toxicity: An eXplainable Artificial Intelligence Approach

Abstract Toxicity prediction in small molecules represents a fundamental challenge in drug development and chemical safety assessment. Traditional approaches heavily rely on predefined molecular descriptors or fingerprints, potentially limiting the ability to capture complex and...

Preoperative brain injury and neurodevelopmental outcomes in syndromic and non-syndromic children with complex congenital heart disease: a single-centre cohort study

Abstract Children with complex congenital heart disease (CHD) are at high risk of brain lesions both before and after cardiac surgery. Preoperative brain injury reflects foetal and perinatal brain development and represents an independent predictor of neurodevelopmental outcome....

Development and Life Cycle Assessment of Wheat Bran-Derived Cellulose-Based Formulations for Extrusion Processing

The large volumes of lignocellulosic residues generated by the paper, wood, and agri-food sectors represent a valuable renewable resource for the sustainable production of chemicals, energy, and bio-based materials. This study explores the valorization of wheat bran, which can be...

Musical Instrument Practice as Sensorimotor and Motor–Cognitive Skill Training in Healthy Aging

Background/Objectives: Playing a musical instrument requires precisely timed movements, bimanual or interlimb coordination, visuomotor mapping, auditory and somatosensory feedback, sequence learning, prediction, and executive regulation. This narrative review synthesizes motor, c...

Secretory Activity in the Longitudinal Canal of Male Podarcis siculus Lizards

In lizards, the longitudinal canal conveys the sperm from the rete testis to the ductuli efferentes, which connect to the cranial end of the epididymal duct. Due to its reduced extension, the longitudinal canal has been largely ignored compared with the ductuli efferentes and the...

Hot-springs through time, and how to find them

Hot-springs have fascinated geologists including James Hutton for centuries. Here we synthesise data collected over timescales from centuries to days to reveal rules governing hot-springs, including where and when they occur. Data reveal waters dominantly sourced from the surface...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

Semilinear damped wave equation on a compact Lie group with a non-autonomous forcing term

Abstract In the present note, we consider a semilinear damped wave equation on a compact Lie group with a non-autonomous nonlinearity $$\varphi (t)|u|^p$$ φ ( t ) | u | p . We are interested in describing how the nonnegative time-dependent factor $$\varphi $$ φ affects the global...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...