University of Bari Aldo Moro

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

The target-engagement predictor, implemented within the InSilicoTrials cloud-based, AI-powered platform for model-informed drug discovery and development, enables early exploration of time-dependent pharmacological responses. Predictions can be generated using inputs ranging from...

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

A game-theoretic assessment of urban road-network vulnerability: a case study of Naples, Italy

Urban road-network vulnerability is difficult to assess when disruption probabilities are unknown and alternative paths perform differently under adverse network conditions. This study proposes a game-theoretic framework in which network users and an adversarial entity interact t...

The One Health Action Plan Against Antimicrobial Resistance

Antimicrobial resistance (AMR) represents a severe problem in public health due to the increasing spread amongst the general population, animals, and the environment of antibiotic-resistant microorganisms with resistance phenotypes extended to more than one class of antibiotics [...

Hominin behavior, strategies, and environmental conditions in Southern Europe (Marine Isotope Stage 17–15): The 100-ka sequence of Notarchirico (Italy, 700–600 ka)

The Notarchirico sequence comprises a continuous 100-ka-long record of phases of hominin occupation between Marine Isotope Stage 17 and Marine Isotope Stage 15, revealing remarkable technological stability alongside some innovations. We analyzed core technology, raw material prov...

Demographic effects of earthquakes in Central and Southern Italy

This paper evaluates the demographic effects of two major earthquakes – L’Aquila 2009 and Central Italy 2016 – that struck a large area in Central and Southern Italy. Using municipality-level data (2002–2023) and a difference-in-differences design with multiple groups and periods...

Training the Next Generation of Future Surgical Residents: A Scoping Review and Proposal for an Undergraduate Curriculum From the Italian Polispecialistic Society of Young Surgeons

AIM: The transition from medical school to surgical residency is marked by a persistent gap between theoretical instruction and clinical readiness. In Italy, variability in training programs across centers creates persistent gaps in residents’ medical education. Scientific societ...

The Proteomic Profiling of a Platelet-Enriched Fraction Identifies an Inflammatory and Immune-Related Signature Associated with Non-Response to Treatment with Plasma Rich in Growth Factors in Knee Osteoarthritis

Background: The use of plasma rich in growth factors (PRGF) is a promising regenerative treatment for knee osteoarthritis (OA), but clinical response is heterogeneous. This study aimed to identify molecular features and explore clinical factors associated with PRGF non-response a...

Rat Hepatitis E Virus ( RHEV ) in Mus musculus and Rattus norvegicus in Northwestern Italy

INTRODUCTION: Hepatitis E virus (HEV) represents a major public health concern. Beyond the main zoonotic genotypes HEV-3 and HEV-4, with pigs and wild boars recognized as the primary reservoirs of infection, a genetically distinct hepevirus of rodent origin (species Rocahepevirus...

Artificial Intelligence-Based Evaluation of Oral Potentially Malignant Disorders Using Photographic and Clinical Data: A Retrospective Exploratory Diagnostic Accuracy Study

Objective: The objective of this study was to evaluate the diagnostic performance of GPT-5.2 Thinking in identifying oral potentially malignant disorders within a patient sample that also included oral carcinomas and other oral cavity lesions, using intraoral photographs and asso...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

A Function-Led Tailored Speech-Language Intervention in Primary Progressive Aphasia: A Retrospective Observational Pre–Post Study From Routine Clinical Practice

PURPOSE: Primary progressive aphasia (PPA) is a neurodegenerative disease that affects language abilities. Since no curative or pharmacological treatments are currently available, speech-language therapy represents one of the few clinical intervention options. Furthermore, eviden...

A Multidisciplinary Care Pathway for Childhood Mouth Breathing: The Pediatric Allergist, ENT, and Orthodontic Perspective

Background: Mouth breathing (MB) in children is a functional alteration characterized by the substitution of nasal breathing with oral or mixed breathing. Persistent MB, particularly when occurring during sleep (nocturnal MB), may be associated with sleep fragmentation, neurobeha...

The GRAVITY score (grading severity and frequency in hemorrhoidal disease): development and initial evaluation of a composite patient-reported outcome measure

Abstract Background Hemorrhoidal disease (HD) is characterized by heterogeneous symptoms including bleeding, prolapse, pain, itching, and soiling. Currently available patient-reported outcome measures evaluate complementary but distinct symptom dimensions. The aim of this study w...

Safeguarding and Valorising European Vegetable Biodiversity Through the Registration of Amateur Varieties: A Critical Analysis

The demand for uniform and high-yielding vegetable varieties has contributed to the erosion of vegetable biodiversity and the marginalisation of locally adapted plant genetic resources (PGR) and landraces that do not meet conventional registration standards. This review criticall...

The robotic PIANO: a critical narrative review of surgeon-controlled operative polyphony, human factors, and robotic training

Abstract Robotic surgery can concentrate control of several technical functions at the console, but such concentration does not itself confer clinical independence, reduce dependence on the perioperative team, or improve patient outcomes. We define surgeon-controlled operative po...

A generalizable biopsychosocial risk score for stratifying disease vulnerability in healthy populations

Prospective risk stratification of future adverse health outcomes before clinical onset among ostensibly healthy individuals is an important goal of preventive and precision medicine, yet current tools remain largely disease-specific and do not provide an integrated measure of he...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

A systematic experimental investigation on the aerodynamic contribution to mooring tension response in floating offshore wind turbines

Quantifying the aerodynamic effects on mooring line tension is essential to distinguish wind-induced impacts from wave-driven dynamics and to improve the understanding of mooring system behaviour under coupled environmental loading conditions. The present work provides the first...